Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Patrick Markt"'
Autor:
Rebecca Herzog, Freya Klepsch, Klaus Kratochwill, Bernd Boidol, Michael Caldera, Y. Folkvaljon, Charles-Hugues Lardeau, Jörg Menche, André C. Müller, Patrick Markt, Sara Sdelci, Gerhard Dürnberger, Vladimir V. Ivanov, Stefan Kubicek, Pär Stattin, Michael Schuster, Thomas Penz, Erika Schirghuber, Christoph Bock, Anna Ringler, Anja Wagner, Jacques Colinge, Keiryn L. Bennett, Marco P. Licciardello
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (7), pp.771-778. ⟨10.1038/nchembio.2382⟩
Nature Chemical Biology, 2017, 13 (7), pp.771-778. ⟨10.1038/nchembio.2382⟩
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (7), pp.771-778. ⟨10.1038/nchembio.2382⟩
Nature Chemical Biology, 2017, 13 (7), pp.771-778. ⟨10.1038/nchembio.2382⟩
International audience; Approved drugs are invaluable tools to study biochemical pathways, and further characterization of these compounds may lead to repurposing of single drugs or combinations. Here we describe a collection of 308 small molecules r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88549e693cbccd83e6eb3bddb6defea
https://hal.umontpellier.fr/hal-02278677
https://hal.umontpellier.fr/hal-02278677
Autor:
Stefano Alcaro, Francesca Esposito, Simona Distinto, Elias Maccioni, Patrick Markt, Johannes Kirchmair, M. Cristina Cardia, Marco Gaspari, Gerhard Wolber, Luca Zinzula, Enzo Tramontano
Publikováno v:
European Journal of Medicinal Chemistry. 50:216-229
We report the first application of ligand-based virtual screening (VS) methods for discovering new compounds able to inhibit both human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT)-associated functions, DNA polymerase and ribonucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abf75707511d83a9f217b66bf383c91
https://doi.org/10.1016/j.ejmech.2012.01.056
https://doi.org/10.1016/j.ejmech.2012.01.056
Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation
Autor:
Hermann Stuppner, Valery N. Bochkov, Judith M. Rollinger, Ulrike Grienke, Patrick Markt, Stefan M. Noha, Daniela Schuster, Gerhard Wolber, Markus Binder, Judit Mihaly-Bison
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
The farnesoid X receptor (FXR) is involved in glucose and lipid metabolism regulation, which makes it an attractive target for the metabolic syndrome, dyslipidemia, atherosclerosis, and type 2 diabetes. In order to find novel
The farnesoid X receptor (FXR) is involved in glucose and lipid metabolism regulation, which makes it an attractive target for the metabolic syndrome, dyslipidemia, atherosclerosis, and type 2 diabetes. In order to find novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45314d07482c6b323c58c1d98b7366c
Autor:
Dorota Kowalik, Patrick Markt, Gabriele Möller, Alex Odermatt, Christian Laggner, Gerhard Wolber, Daniela Schuster, Fabian Ströhle, Jerzy Adamski, Thomas Wilckens, Johannes Kirchmair, Christel Aebischer-Gumy, Thierry Langer
Publikováno v:
The Journal of steroid biochemistry and molecular biology
17β-Hydroxysteroid dehydrogenase type 3 and 5 (17β-HSD3 and 17β-HSD5) catalyze testosterone biosynthesis and thereby constitute therapeutic targets for androgen-related diseases or endocrine-disrupting chemicals. As a fast and efficient tool to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2f54a6170df195d1e71a07296836bb
https://doi.org/10.1016/j.jsbmb.2011.01.016
https://doi.org/10.1016/j.jsbmb.2011.01.016
Autor:
Hermann Stuppner, Gerhard Wolber, Judith M. Rollinger, Daniela Schuster, Julia Bauer, Oliver Werz, Stefan M. Noha, Patrick Markt, Katja Wiechmann, Birgit Waltenberger
Publikováno v:
Journal of Medicinal Chemistry. 54:3163-3174
Microsomal prostaglandin E2 synthase-1 (mPGES-1) catalyzes prostaglandin E2 formation and is considered as a potential anti-inflammatory pharmacological target. To identify novel chemical scaffolds active on this enzyme, two pharmacophore models for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67501fe64d670b72a9ca269ed712883e
https://doi.org/10.1021/jm101309g
https://doi.org/10.1021/jm101309g
Autor:
Tatyana Kharlamova, Angela Corona, Francesca Esposito, Giovanni Floris, Simona Distinto, Luca Zinzula, Yung-Chi Cheng, Ginger E. Dutschman, Enzo Tramontano, Patrick Markt
Publikováno v:
FEBS Journal. 278:1444-1457
HIV-1 reverse transcriptase (RT) has two associated activities, DNA polymerase and RNase H, both essential for viral replication and validated drug targets. Although all RT inhibitors approved for therapy target DNA polymerase activity, the search fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8813646dc3f7b6f952e7aacdea8e384c
https://doi.org/10.1111/j.1742-4658.2011.08057.x
https://doi.org/10.1111/j.1742-4658.2011.08057.x
Autor:
Verena M. Dirsch, Atanas G. Atanasov, Judith M. Rollinger, Hermann Stuppner, Stefan M. Noha, Gerhard Wolber, Patrick Markt, Elke H. Heiss, Daniela Schuster, Nanang Fakhrudin, Olivia Schrammel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Various inflammatory stimuli that activate the nuclear factor kappa B (NF-κB) signaling pathway converge on a serine/threonine kinase that displays a key role in the activation of NF-κB: the I kappa B kinase β (IKK-β). The
Various inflammatory stimuli that activate the nuclear factor kappa B (NF-κB) signaling pathway converge on a serine/threonine kinase that displays a key role in the activation of NF-κB: the I kappa B kinase β (IKK-β). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539a65ad751daf698ea228b3ec404a08
http://europepmc.org/articles/PMC3013379
http://europepmc.org/articles/PMC3013379
Autor:
Ulrich Kintscher, Patrick Markt, Gerhard Wolber, Thomas Unger, Matthias Goebel, Ronald Gust, Bart Staels
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:5885-5895
In this and previous studies we investigated the importance of partial structures of Telmisartan on PPARgamma activation. The biphenyl-4-ylmethyl moiety at N1 and residues at C2 of the central benzimidazole were identified to be essential for recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8550a8a73f62c3ae0c7d229e5fac177c
https://doi.org/10.1016/j.bmc.2010.06.102
https://doi.org/10.1016/j.bmc.2010.06.102
Autor:
Daniela Schuster, Patrick Markt, Simona Distinto, Johannes Kirchmair, Judith M. Rollinger, Hermann Stuppner, Gerhard Wolber, Birgit Waltenberger
Publikováno v:
Molecular Informatics. 29:75-86
3D pharmacophore modeling has evolved as an established and state-of-the-art method for performing in-silico predictions of biological activity. Using one single model is limited to single binding modes, while the combination of several models bears
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269e64f7313e6020b60846636d19d4ce
https://doi.org/10.1002/minf.200900071
https://doi.org/10.1002/minf.200900071
Autor:
Elke H. Heiss, Patrick Markt, Angela Ladurner, Atanas G. Atanasov, Verena M. Dirsch, Ernst P. Ellmerer, Lisa Baumgartner, Gerhard Wolber, Hermann Stuppner, Daniela Schuster, Nanang Fakhrudin, Judith M. Rollinger
Publikováno v:
Molecular Pharmacology. 77:559-566
Peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists are used for the treatment of type 2 diabetes and metabolic syndrome. However, the currently used PPAR gamma agonists display serious side effects, which has led to a great intere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1de738db36d17570e10bdff37962402
https://doi.org/10.1124/mol.109.062141
https://doi.org/10.1124/mol.109.062141