Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Patrick, Yip"'
Autor:
Tyler D. R. Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E. Lee
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The crystal structure of sperm-expressed surface protein SPACA6 shows similarities to IZUMO1 though their functions are not redundant. Structural homology search in the AlphaFold human proteome and sequence search suggest a superfamily of mammalian g
Externí odkaz:
https://doaj.org/article/5103ed85da4846eba054e5b2109b21e5
Autor:
Tyler D.R. Vance, Patrick Yip, Elisabet Jiménez, Sheng Li, Diana Gawol, James Byrnes, Isabel Usón, Ahmed Ziyyat, Jeffrey E. Lee
SPACA6 is a sperm-expressed surface protein that is critical for gamete fusion during mammalian sexual reproduction. Despite this fundamental role, little is known about how SPACA6 specifically functions. We elucidated the crystal structure of SPACA6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a846064a19a7a2ea5d5b6e6ca2d984
https://doi.org/10.1101/2022.03.23.484325
https://doi.org/10.1101/2022.03.23.484325
Autor:
Yongzhen Zhang, Mark Nitz, François Le Mauff, Jeroen D. C. Codée, Caitlin A. Zacharias, Claudia Millán, Donald C. Sheppard, Patrick Yip, Natalie C. Bamford, Isabel Usón, P. Lynne Howell, Adithya S. Subramanian, Adam Forman
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 294(37), 13833-13849
Journal of Biological Chemistry, 294(37), 13833-13849
Aspergillus fumigatus is an opportunistic fungal pathogen that causes both chronic and acute invasive infections. Galactosaminogalactan (GAG) is an integral component of the A. fumigatus biofilm matrix and a key virulence factor. GAG is a heterogeneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d809ff0a54948a7b59fa0bfbbf4f9d63
https://hdl.handle.net/1887/79805
https://hdl.handle.net/1887/79805
Autor:
Natalie C, Bamford, François, Le Mauff, Adithya S, Subramanian, Patrick, Yip, Claudia, Millán, Yongzhen, Zhang, Caitlin, Zacharias, Adam, Forman, Mark, Nitz, Jeroen D C, Codée, Isabel, Usón, Donald C, Sheppard, P Lynne, Howell
Publikováno v:
The Journal of biological chemistry. 294(37)
Aspergillus fumigatus is an opportunistic fungal pathogen that causes both chronic and acute invasive infections. Galactosaminogalactan (GAG) is an integral component of the A. fumigatus biofilm matrix and a key virulence factor. GAG is a heterogeneo
Autor:
P. Lynne Howell, John C. Whitney, Gregory B. Whitfield, A. Mirela Neculai, Howard Robinson, Yuri D. Lobsanov, Dennis E. Ohman, Lindsey S. Marmont, Patrick Yip
Publikováno v:
Journal of Biological Chemistry. 290:12451-12462
Pseudomonas aeruginosa is an opportunistic human pathogen that secretes the exopolysaccharide alginate during infection of the respiratory tract of individuals afflicted with cystic fibrosis and chronic obstructive pulmonary disease. Among the protei
Autor:
Laura B. Giesbrecht, Jacquelyn D. Rich, Lindsey S. Marmont, P. Lynne Howell, Matthew R. Parsek, Carol A. Stremick, John C. Whitney, Gregory B. Whitfield, Patrick Yip, Joe J. Harrison
The pellicle (PEL) polysaccharide is synthesized by the opportunistic pathogen Pseudomonas aeruginosa and is an important biofilm constituent critical for bacterial virulence and persistence. PEL is a cationic polymer that promotes cell-cell interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1cab3d210fa9abc776fdcfaae981a1
https://europepmc.org/articles/PMC5702679/
https://europepmc.org/articles/PMC5702679/
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 68:842-845
The periplasmic poly-β-1,6-N-acetyl-D-glucosamine (PNAG) de-N-acetylase PgaB fromEscherichia coliwas overexpressed and purified, but was recalcitrant to crystallization. Use of thein situproteolysis technique produced crystals of PgaB, but these cry
Autor:
Annette Herscovics, Marc Claeyssens, T. Yoshida, Wim Nerinckx, Tom Desmet, P.L. Howell, Y.D. Lobsanov, Patrick Yip
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 64:227-236
Class I alpha-mannosidases (glycoside hydrolase family GH47) play key roles in the maturation of N-glycans and the ER-associated degradation of unfolded glycoproteins. The 1.95 A resolution structure of a fungal alpha-1,2-mannosidase in complex with
Autor:
Shao Yang Ku, Jean-Bernard Behr, P. Lynne Howell, Kenneth A. Cornell, Patrick Yip, Georges Guillerm, Michael K. Riscoe
Publikováno v:
Journal of Biological Chemistry. 282:22195-22206
The methionine salvage pathway is ubiquitous in all organisms, but metabolic variations exist between bacteria and mammals. 5-Methylthioribose (MTR) kinase is a key enzyme in methionine salvage in bacteria and the absence of a mammalian homolog sugge
Autor:
Annette Herscovics, P. Lynne Howell, Bomina Yu, Yuri D. Lobsanov, Pedro A. Romero, Patrick Yip, Barry Sleno
Publikováno v:
Journal of Biological Chemistry. 279:17921-17931
Kre2p/Mnt1p is a Golgi alpha1,2-mannosyltransferase involved in the biosynthesis of Saccharomyces cerevisiae cell wall glycoproteins. The protein belongs to glycosyltransferase family 15, a member of which has been implicated in virulence of Candida