TP53 Mutations Identified Using NGS Comprise the Overwhelming Majority of TP53 Disruptions in CLL: Results From a Multicentre Study

Autor: Mark A. Catherwood, Dorte Wren, Laura Chiecchio, Doriane Cavalieri, David Donaldson, Sarah Lawless, Ezzat ElHassadi, Amjad Hayat, Mary R. Cahill, Derville O’Shea, Jeremy Sargent, Peter Stewart, Manisha Maurya, John Quinn, Philip Murphy, David Gonzalez de Castro, Ken Mills, Nicholas C. P. Cross, Francesco Forconi, Sunil Iyengar, Anna Schuh, Patrick Thornton

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Limited data exists to show the correlation of (tumour protein 53) TP53 mutation detected by Next generation sequencing (NGS) and the presence/absence of deletions of 17p13 detected by FISH. The study which is the largest series to date includes 2332

Externí odkaz: https://doaj.org/article/f68447793d1e43bead15fecab502e322

Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia

Autor: Fary Diop, Riccardo Moia, Chiara Favini, Elisa Spaccarotella, Lorenzo De Paoli, Alessio Bruscaggin, Valeria Spina, Lodovico Terzi-di-Bergamo, Francesca Arruga, Chiara Tarantelli, Clara Deambrogi, Silvia Rasi, Ramesh Adhinaveni, Andrea Patriarca, Simone Favini, Sruthi Sagiraju, Clive Jabangwe, Ahad A. Kodipad, Denise Peroni, Francesca R. Mauro, Ilaria Del Giudice, Francesco Forconi, Agostino Cortelezzi, Francesco Zaja, Riccardo Bomben, Francesca Maria Rossi, Carlo Visco, Annalisa Chiarenza, Gian Matteo Rigolin, Roberto Marasca, Marta Coscia, Omar Perbellini, Alessandra Tedeschi, Luca Laurenti, Marina Motta, David Donaldson, Phil Weir, Ken Mills, Patrick Thornton, Sarah Lawless, Francesco Bertoni, Giovanni Del Poeta, Antonio Cuneo, Antonia Follenzi, Valter Gattei, Renzo Luciano Boldorini, Mark Catherwood, Silvia Deaglio, Robin Foà, Gianluca Gaidano°, Davide Rossi°

Publikováno v: Haematologica, Vol 105, Iss 2 (2020)

BIRC3 is a recurrently mutated gene in chronic lymphocytic leukemia (CLL) but the functional implications of BIRC3 mutations are largely unexplored. Furthermore, little is known about the prognostic impact of BIRC3 mutations in CLL cohorts homogeneou

Externí odkaz: https://doaj.org/article/a9268fbe11e941109905bc1ded8e6bf5

First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia

Autor: Barbara Eichhorst, Carsten U. Niemann, Arnon P. Kater, Moritz Fürstenau, Julia von Tresckow, Can Zhang, Sandra Robrecht, Michael Gregor, Gunnar Juliusson, Patrick Thornton, Philipp B. Staber, Tamar Tadmor, Vesa Lindström, Caspar da Cunha-Bang, Christof Schneider, Christian B. Poulsen, Thomas Illmer, Björn Schöttker, Thomas Nösslinger, Ann Janssens, Ilse Christiansen, Michael Baumann, Henrik Frederiksen, Marjolein van der Klift, Ulrich Jäger, Maria B.L. Leys, Mels Hoogendoorn, Kourosh Lotfi, Holger Hebart, Tobias Gaska, Harry Koene, Lisbeth Enggaard, Jereon Goede, Josien C. Regelink, Anouk Widmer, Florian Simon, Nisha De Silva, Anna-Maria Fink, Jasmin Bahlo, Kirsten Fischer, Clemens-Martin Wendtner, Karl A. Kreuzer, Matthias Ritgen, Monika Brüggemann, Eugen Tausch, Mark-David Levin, Marinus van Oers, Christian Geisler, Stephan Stilgenbauer, Michael Hallek

Publikováno v: Eichhorst, B, Niemann, C U, Kater, A P, Fürstenau, M, von Tresckow, J, Zhang, C, Robrecht, S, Gregor, M, Juliusson, G, Thornton, P, Staber, P B, Tadmor, T, Lindström, V, da Cunha-Bang, C, Schneider, C, Poulsen, C B, Illmer, T, Schöttker, B, Nösslinger, T, Janssens, A, Christiansen, I, Baumann, M, Frederiksen, H, van der Klift, M, Jäger, U, Leys, M B L, Hoogendoorn, M, Lotfi, K, Hebart, H, Gaska, T, Koene, H, Enggaard, L, Goede, J, Regelink, J C, Widmer, A, Simon, F, De Silva, N, Fink, A-M, Bahlo, J, Fischer, K, Wendtner, C-M, Kreuzer, K A, Ritgen, M, Brüggemann, M, Tausch, E, Levin, M-D, van Oers, M, Geisler, C, Stilgenbauer, S, Hallek, M, German CLL Study Group (GCLLSG), Haemato-Oncology Foundation for Adults in the Netherlands (HOVON), Nordic CLL Study Groups, Swiss Group for Clinical Cancer Research (SAKK), The Israeli CLL Association & Cancer Trials Ireland 2023, ' First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia ', The New England Journal of Medicine, vol. 388, no. 19, pp. 1739-1754 . https://doi.org/10.1056/NEJMoa2213093

BACKGROUNDRandomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking.METHODSIn a phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57065540dd32adf0cc1d031449d13807
https://vbn.aau.dk/da/publications/3cae35e7-c81b-42b3-8598-001ac74af83e

Genetic Markers and Front Line FCR/BR Vs. Rve, Gve and Give Treatment - Outcome Results from the CLL13/GAIA Trial

Autor: Eugen Tausch, Christof Schneider, Moritz Furstenau, Sandra Robrecht, Deyan Yordanov Yosifov, Daniel Mertens, Michael Gregor, Patrick Thornton, Philipp B. Staber, Tamar Tadmor, Mark-David Levin, Caspar da Cunha-Bang, Christian Bjørn Poulsen, Thomas Illmer, Björn Schöttker, Ann Janssens, Ilse Christiansen, Thomas Noesslinger, Michael Baumann, Clemens-Martin Wendtner, Eric Eldering, Karl-Anton Kreuzer, Matthias Ritgen, Anna-Maria Fink, Kirsten Fischer, Arnon P. Kater, Carsten Utoft Niemann, Michael Hallek, Barbara Eichhorst, Stephan Stilgenbauer

Publikováno v: Tausch, E, Schneider, C, Furstenau, M, Robrecht, S, Yosifov, D Y, Mertens, D, Gregor, M, Thornton, P, Staber, P B, Tadmor, T, Levin, M-D, da Cunha-Bang, C, Poulsen, C B, Illmer, T, Schöttker, B, Janssens, A, Christiansen, I, Noesslinger, T, Baumann, M, Wendtner, C-M, Eldering, E, Kreuzer, K-A, Ritgen, M, Fink, A-M, Fischer, K, Kater, A P, Niemann, C U, Hallek, M, Eichhorst, B & Stilgenbauer, S 2022, ' Genetic Markers and Front Line FCR/BR Vs. Rve, Gve and Give Treatment-Outcome Results from the CLL13/GAIA Trial ', Blood, vol. 140, no. Suppl. 1, 642, pp. 839–841 . https://doi.org/10.1182/blood-2022-163775

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1745830886146743b130354e8c86e89a
https://vbn.aau.dk/da/publications/e4f272b1-3bbd-47c3-b141-87d083c3decd

Measuring the Impact of Trauma-Focused, Cognitive Behavioral Group Therapy with Middle School Students

Autor: Katrina D. Roundfield, Michelle W. Woodbridge, S. Patrick Thornton, W. Carl Sumi, Xin Wei

Publikováno v: School Mental Health. 13:680-694

This study examines differential effects of the Cognitive Behavioral Intervention for Trauma in Schools (CBITS) program on behavioral and academic outcomes of middle school students. Researchers administered screenings to grade 6 students to assess t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a714bcae9bdc814cc35d2c7ae6358fc
https://doi.org/10.1007/s12310-021-09452-8