Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Patrick, Schweder"'
Autor:
Elizabeth Cooper, Caitlin R. M. Oyagawa, Rebecca Johnson, Peter J. Choi, Jena Macapagal Foliaki, Jason Correia, Patrick Schweder, Peter Heppner, Edward Mee, Clinton Turner, Richard Faull, William A. Denny, Mike Dragunow, Jiney Jose, Thomas I-H. Park
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Glioblastoma is the most common and aggressive primary brain tumour in adults. The development of anti-brain cancer agents are challenged by the blood-brain barrier and the resistance conferred by the local tumour microenvironment. Heptameth
Externí odkaz:
https://doaj.org/article/e89e926fe6974ecaa78c8ebfb63ce277
Autor:
Taylor J. Stevenson, Rebecca H. Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C. D. Smyth, Helen C. Murray, Richard L. M. Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V. Dieriks, Maurice A. Curtis, Michael Dragunow
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). Pericytes and microglia, two non-neuronal cells contain α-syn in the human brain, how
Externí odkaz:
https://doaj.org/article/0a4e76a833d74d76a95832207eacbaf4
Autor:
Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Smyth et al. use tissue microarrays from Alzheimer’s disease (AD) patient brains to show that PDGF-BB:PDGFRβ signalling components are reduced in AD. They then use primary human brain pericytes to elucidate a pathway by which PDGF-BB:PDGFRβ signa
Externí odkaz:
https://doaj.org/article/ac4315ac00c245ed917bf0edddaef79a
Autor:
Yi-Han Wu, Thomas I-H Park, Eryn Kwon, Sheryl Feng, Patrick Schweder, Mike Dragunow, Vickie Shim, Samuel Rosset
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Traumatic brain injury (TBI) is defined as brain damage due to an external force that negatively impacts brain function. Up to 90% of all TBI are considered in the mild severity range (mTBI) but there is still no therapeutic solution available. There
Externí odkaz:
https://doaj.org/article/f79912511f754fc895906143b3af0395
Autor:
Deidre Jansson, Victor Birger Dieriks, Justin Rustenhoven, Leon C. D. Smyth, Emma Scotter, Miranda Aalderink, Sheryl Feng, Rebecca Johnson, Patrick Schweder, Edward Mee, Peter Heppner, Clinton Turner, Maurice Curtis, Richard Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulato
Externí odkaz:
https://doaj.org/article/16813cdb8f5946e8a7e3b8526d12998c
Autor:
Birger Victor Dieriks, Blake Highet, Ania Alik, Tracy Bellande, Taylor J Stevenson, Victoria Low, Thomas I-H Park, Jason Correia, Patrick Schweder, Richard L M Faull, Ronald Melki, Maurice A Curtis, Mike Dragunow
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277658 (2022)
Parkinson's disease (PD) is a progressive, neurodegenerative disorder characterised by the abnormal accumulation of α-synuclein (α-syn) aggregates. Central to disease progression is the gradual spread of pathological α-syn. α-syn aggregation is c
Externí odkaz:
https://doaj.org/article/5f2cfb2582e6453fbb3bc0f68763258f
Autor:
Justin Rustenhoven, Amy M. Smith, Leon C. Smyth, Deidre Jansson, Emma L. Scotter, Molly E. V. Swanson, Miranda Aalderink, Natacha Coppieters, Pritika Narayan, Renee Handley, Chris Overall, Thomas I. H. Park, Patrick Schweder, Peter Heppner, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-16 (2018)
Abstract Background Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding the molecular events underpinning microglial functions and activation states will further enable us to target these cells for
Externí odkaz:
https://doaj.org/article/61d01fe126004e1d9256ea1766c25fa5
Autor:
Leon C. D. Smyth, Justin Rustenhoven, Thomas I.-H. Park, Patrick Schweder, Deidre Jansson, Peter A. Heppner, Simon J. O’Carroll, Edward W. Mee, Richard L. M. Faull, Maurice Curtis, Mike Dragunow
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Pericytes and endothelial cells are critical cellular components of the blood-brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of inflammation-related studies in endothelia and pericytes h
Externí odkaz:
https://doaj.org/article/63936bf9cba943b9bb8265ccf406b16c
Autor:
Cameron Bringans, Callum Hammond, Jiwon Hong, Hsiang-Wei Wang, Patrick Schweder, Jason Correia, John Windsor, Paul Kilmartin, Simon O'Carroll, Anthony Phillips
Publikováno v:
World Neurosurgery. 161:e183-e191
Spinal cord injury (SCI) triggers a signalling cascade that produces oxidative stress and damages the spinal cord. Voltammetry is a clinically accessible technique to detect, monitor, and guide correction of this potentially reversible secondary inju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80217c875afb5e3b0d101efc332eec51
https://doi.org/10.1016/j.wneu.2022.01.099
https://doi.org/10.1016/j.wneu.2022.01.099
Autor:
Thomas I.-H. Park, Leon C. D. Smyth, Miranda Aalderink, Zoe R. Woolf, Justin Rustenhoven, Kevin Lee, Deidre Jansson, Amy Smith, Sheryl Feng, Jason Correia, Peter Heppner, Patrick Schweder, Edward Mee, Mike Dragunow
Publikováno v:
Nature Protocols. 17:190-221
When modeling disease in the laboratory, it is important to use clinically relevant models. Patient-derived human brain cells grown in vitro to study and test potential treatments provide such a model. Here, we present simple, highly reproducible coo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01203b468e4e91b5c4fff19aab190b44
https://doi.org/10.1038/s41596-021-00637-8
https://doi.org/10.1038/s41596-021-00637-8