Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Patrick, Schindler"'
Autor:
Shuhei Nishiyama, Jin Myong Seok, Amy E. Wright, Itay Lotan, Takahisa Mikami, Natalia C. Drosu, Natasha Bobrowski-Khoury, Monique R. Anderson, Philippe A. Bilodeau, Patrick Schindler, Friedemann Paul, Masashi Aoki, Michael R. Yeaman, Michael Levy, The Guthy-Jackson Charitable Foundation CIRCLES Study Group
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Proinflammatory cytokines, such as (IL: interleukin) IL-6 and IL-17A, and complement fixation are critical in the immunopathogenesis of neuromyelitis optica spectrum disorders (NMOSD). Blocking the IL-6 receptor or the C5 complement pathway
Externí odkaz:
https://doaj.org/article/aedaf31a7f7349ebb6c22664c55bd90c
Autor:
Susanna Asseyer, Ofir Zmira, Laura Busse, Barak Pflantzer, Patrick Schindler, Tanja Schmitz-Hübsch, Friedemann Paul, Claudia Chien
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
ObjectiveAquaporin-4-antibody-seropositive (AQP4-IgG+) Neuromyelitis Optica Spectrum Disorder (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder (MOGAD) are relapsing neuroinflammatory diseases, frequently leading to chronic
Externí odkaz:
https://doaj.org/article/a966b52199f8463b89ebcaa376331a83
Autor:
Maria Schroeder-Castagno, Alba Del Rio-Serrato, Andreas Wilhelm, Silvina Romero-Suárez, Patrick Schindler, Cesar Alvarez-González, Ankelien-Solveig Duchow, Judith Bellmann-Strobl, Klemens Ruprecht, Maria Hastermann, Gerald Grütz, Brigitte Wildemann, Sven Jarius, Tanja Schmitz-Hübsch, Friedemann Paul, Carmen Infante-Duarte
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background In neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neutrophils are found in CNS lesions. We previously demonstrated that NMOSD neutrophils show functiona
Externí odkaz:
https://doaj.org/article/db49c69e83c54a4a9442b01f0b920841
Autor:
Rahel H. Wallimann, Heloïse Hensinger, Cristina Müller, Roger Schibli, Rainer Kneuer, Patrick Schindler
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 299 (2024)
In recent years, nuclear medicine has gained great interest, partly due to the success story of [177Lu]Lu-PSMA-617 (PluvictoTM). Still, in-depth preclinical characterization of radiopharmaceuticals mainly happens at centers that allow working with ra
Externí odkaz:
https://doaj.org/article/77bda5efd8434174b9780130724b3d16
Autor:
Patrick Schindler, Ulrike Grittner, Johanna Oechtering, David Leppert, Nadja Siebert, Ankelien S. Duchow, Frederike C. Oertel, Susanna Asseyer, Joseph Kuchling, Hanna G. Zimmermann, Alexander U. Brandt, Pascal Benkert, Markus Reindl, Sven Jarius, Friedemann Paul, Judith Bellmann-Strobl, Jens Kuhle, Klemens Ruprecht
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-14 (2021)
Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is a frequently disabling neuroinflammatory syndrome with a relapsing course. Blood-based disease severity and prognostic biomarkers for NMOSD are a yet unmet clinical need. Here, we
Externí odkaz:
https://doaj.org/article/f8c3f49938d94a87a492216c3c930a0b
Autor:
Darius Mewes, Joseph Kuchling, Patrick Schindler, Ahmed Abdelrahim Ahmed Khalil, Sven Jarius, Friedemann Paul, Claudia Chien
Publikováno v:
Klinische Monatsblätter für Augenheilkunde. 239:1315-1324
ZusammenfassungDie Aquaporin-4-Antikörper-positive Neuromyelitis-optica-Spektrum-Erkrankung (engl. NMOSD) und die Myelin-Oligodendrozyten-Glykoprotein-Antikörper-assoziierte Erkrankung (engl. MOGAD) sind Autoimmunerkrankungen des zentralen Nervensy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec2574446de1299a5693cd8a0d1f721f
https://doi.org/10.1055/a-1918-1824
https://doi.org/10.1055/a-1918-1824
Autor:
Tatjana Schwarz, Carolin Otto, Terry C Jones, Florence Pache, Patrick Schindler, Moritz Niederschweiberer, Felix A Schmidt, Christian Drosten, Victor M Corman, Klemens Ruprecht
Publikováno v:
Multiple Sclerosis Journal. 28:1041-1050
Background: Optimal management of anti-CD20-treated patients with multiple sclerosis (pwMS) is an important clinical task during the current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. Objectives: To characterize humoral an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d7cfdb1b594b9e8f888d4873df1fbd
https://doi.org/10.1177/13524585221094478
https://doi.org/10.1177/13524585221094478
Autor:
Rahel H. Wallimann, Patrick Schindler, Heloïse Hensinger, Viviane J. Tschan, Sarah D. Busslinger, Rainer Kneuer, Cristina Müller, Roger Schibli
Publikováno v:
Molecular Pharmaceutics, 20 (4)
This study addresses the question whether in-ductively coupled plasma mass spectrometry (ICP-MS) can be used as a method for the in vitro and in vivo characterization of non-radioactive metal conjugates to predict the properties of analogous radiopha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b972985462646e270026444bc1106f
Autor:
Patrick Schindler, Orhan Aktas, Marius Ringelstein, Brigitte Wildemann, Sven Jarius, Friedemann Paul, Klemens Ruprecht
Publikováno v:
Expert review of clinical immunology. 19(1)
Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, often debilitating neuroinflammatory disease, whose predominant clinical manifestations are longitudinally extensive transverse myelitis and optic neuritis. About 80% of the patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d142a6da7fa9db544202dd5afdffe874
https://pubmed.ncbi.nlm.nih.gov/36378751
https://pubmed.ncbi.nlm.nih.gov/36378751
Autor:
Babette Wolf, Mateusz Piksa, Isabelle Beley, Agnes Patoux, Thierry Besson, Valerie Cordier, Bernd Voedisch, Patrick Schindler, Daniela Stöllner, Ludovic Perrot, Stephan von Gunten, Dominique Brees, Michael Kammüller
Publikováno v:
Wolf, Babette; Piksa, Mateusz; Beley, Isabelle; Patoux, Agnes; Besson, Thierry; Cordier, Valerie; Voedisch, Bernd; Schindler, Patrick; Stöllner, Daniela; Perrot, Ludovic; von Gunten, Stephan; Brees, Dominique; Kammüller, Michael (2022). Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity. Immunology, 166(3), pp. 380-407. Wiley-Blackwell 10.1111/imm.13481
In this study we show that glycosylation is relevant for immune recognition of therapeutic antibodies, and that defined glycan structures can modulate immunogenicity. Concerns regarding immunogenicity arise from the high heterogeneity in glycosylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899fb5623b3687d80a73150bc1daf188
https://boris.unibe.ch/169303/1/Immunology_-_2022_-_Wolf_-_Therapeutic_antibody_glycosylation_impacts_antigen_recognition_and_immunogenicity.pdf
https://boris.unibe.ch/169303/1/Immunology_-_2022_-_Wolf_-_Therapeutic_antibody_glycosylation_impacts_antigen_recognition_and_immunogenicity.pdf