Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs

Autor: Patrick Pfaff, Kusal T. G. Samarasinghe, Craig M. Crews, Erick M. Carreira

Publikováno v: ACS Central Science, Vol 5, Iss 10, Pp 1682-1690 (2019)

Externí odkaz: https://doaj.org/article/275e9de7d62243c0bbe092c107de5671

Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

Autor: Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Claudia Korn, David Sykes, Gabriel Forn-Cuni, Patrick Pfaff, Roman C. Sarott, Matthias V. Westphal, Yelena Mostinski, Leonard Mach, Malgorzata Wasinska-Kalwa, Marie Weise, Bradley L. Hoare, Tamara Miljuš, Maira Mexi, Nicolas Roth, Eline J. Koers, Wolfgang Guba, André Alker, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Matthias Nettekoven, Irene Benito-Cuesta, Teresa Grande, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Michael Honer, Jürgen Fingerle, Jörg Scheffel, Johannes Broichhagen, Klaus Gawrisch, Julián Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Jürg Gertsch, Christoph Ullmer, Peter J. McCormick, Sergio Oddi, Herman P. Spaink, Mauro Maccarrone, Dmitry B. Veprintsev, Erick M. Carreira, Uwe Grether, Marc Nazaré

Publikováno v: Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Korn, Claudia; Sykes, David; Forn-Cuni, Gabriel; Pfaff, Patrick; Sarott, Roman C; Westphal, Matthias V; Mostinski, Yelena; Mach, Leonard; Wasinska-Kalwa, Malgorzata; Weise, Marie; Hoare, Bradley L; Miljuš, Tamara; Mexi, Maira; Roth, Nicolas; Koers, Eline J; Guba, Wolfgang; Alker, André; ... (2022). Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. Chemical Science, 13(19), pp. 5539-5545. The Royal Society of Chemistry 10.1039/d1sc06659e
Chemical Science, 13(19), 5539-5545
Chemical Science

Despite its essential role in the (patho)physiology of several diseases, CB2R tissue expression profiles and signaling mechanisms are not yet fully understood. We report the development of a highly potent, fluorescent CB2R agonist probe employing str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e61ac61b6e5b29da1ceeb545f2c056
http://hdl.handle.net/11697/192023

Challenging the Molecular Parameters of Vetiver: Can 4,5-Dimethyl-3-(3′-methylbut-1′-en-2′-yl)-4-phenylcyclopent-2-en-1-one Mimic Zizaenones in Structure and Odor?

Autor: Philip Kraft, Patrick Pfaff, Halima Mouhib

Publikováno v: European Journal of Organic Chemistry. 2019:2643-2652

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1559594ceec4c0f9b147a4048a1f8cbb
https://doi.org/10.1002/ejoc.201900163

Optical Control of Cannabinoid Receptor 2–Mediated Ca2+ Release Enabled By Synthesis of Photoswitchable Probes

Autor: Roman Sarott, Alexander E.G. Viray, Patrick Pfaff, Anastasiia Sadybekov, Gabriela Rajic, Vsevolod Katritch, Erick Carreira, James Frank

Cannabinoid receptor 2 (CB2) is a promising target for the treatment of neuroinflammation and other diseases. Howev-er, lack of understanding of its complex signaling in cells and tissues complicates its therapeutic targeting. For the first time we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b610362e8534ef1425c2f0bc4dc9bf49
https://doi.org/10.26434/chemrxiv.12722498.v1

Total Synthesis of (+)-Prostratin

Autor: Patrick Pfaff, Erick M. Carreira

Publikováno v: Synfacts. 17:1079

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d84c0fc2792c72bcc583002a04e6caf8
https://doi.org/10.1055/s-0040-1720188