Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Patrick, Pasau"'
Publikováno v:
The Journal of Physical Chemistry A. 127:2628-2636
Autor:
Agostinho Luís Pereira Lemos, Laura Trump, Bénédicte Lallemand, Patrick Pasau, Joël Mercier, Christian Lemaire, Jean-Christophe Monbaliu, Christophe Genicot, André Luxen
Publikováno v:
Catalysts, Vol 10, Iss 3, p 275 (2020)
The 18F-labeling of CF2H groups has been recently studied in radiopharmaceutical chemistry owing to the favorable nuclear and physical characteristics of the radioisotope 18F for positron emission tomography (PET). Following up on the reported effici
Externí odkaz:
https://doaj.org/article/0e8ec59a819a4cd8b6adb14f55ae6eb0
Autor:
James R. Frost, Julien Brown, Jean-Paul Kestemont, Jérôme Jacq, Patrick Pasau, Frédéric Perl, Matthieu Tissot
Publikováno v:
Organic Process Research & Development. 26:635-639
Publikováno v:
Organic Process Research & Development. 24:802-806
We report an amination of mesylated cyclobutanol enabled by a multistep continuous flow process. The flow sequence involved an azidation followed by a Staudinger reduction which avoids the handling...
Late‐Stage 18F‐Difluoromethyl Labeling of N‐Heteroaromatics with High Molar Activity for PET Imaging
Autor:
Joël Mercier, Patrick Pasau, Laura Trump, André Luxen, Christophe Genicot, Benedicte Lallemand, Agostinho Lemos, Christian Lemaire
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie International Edition
Despite a growing interest in CHF2 in medicinal chemistry, there is a lack of efficient methods for the insertion of CHF18F into druglike compounds. Herein described is a photoredox flow reaction for 18F‐difluoromethylation of N‐heteroaromatics t
Publikováno v:
Organic Letters
Oxadiazolines are bench-stable diazo precursors, which are activated under UV radiation in the presence of vinylboronic acids and aldehydes to enable a one-step three-component assembly of densely functionalized homoallylic alcohols. Substitution on
Autor:
Sylvain Petit, Nathalie Body, Matthieu Tissot, Patrick Pasau, Jehan Claessens, Christophe Genicot
Publikováno v:
Organic letters. 20(24)
Synthesis of 1,3-substituted cyclobutyls enabled by zinc insertion into functionalized iodocyclobutyl derivatives followed by Negishi coupling with halo-heteroaromatics is reported. Two distinct sets of conditions were developed; the first involved a
Autor:
Ricardo Labes, Claudio Battilocchio, Steven V. Ley, Christophe Genicot, Jérôme Jacq, Mathieu Lesieur, Patrick Pasau
Publikováno v:
Chemistry – A European Journal.
A fast, scalable, and safer Csp3 -H oxidation of activated and un-activated aliphatic chains can be enabled by methyl(trifluoromethyl)dioxirane (TFDO). The continuous flow platform allows the in situ generation of TFDO gas and its rapid reactivity to
Autor:
Mathieu, Lesieur, Claudio, Battilocchio, Ricardo, Labes, Jérôme, Jacq, Christophe, Genicot, Steven V, Ley, Patrick, Pasau
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(5)
A fast, scalable, and safer C
Autor:
Paul, Dingwall, Andreas, Greb, Lorène N S, Crespin, Ricardo, Labes, Biagia, Musio, Jian-Siang, Poh, Patrick, Pasau, David C, Blakemore, Steven V, Ley
Publikováno v:
Chemical communications (Cambridge, England). 54(83)
The difficulty in accessing and safely utilising non-stabilised diazo species has in the past limited the application of this class of compounds. Here we explore further the use of oxadiazolines, non-stabilised diazo precursors which are bench stable