Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Patrick, Most"'
Autor:
Ann‐Kathrin Rahm, Teresa Wieder, Dominik Gramlich, Mara Elena Müller, Maximilian N. Wunsch, Fadwa A. El Tahry, Tanja Heimberger, Steffi Sandke, Tanja Weis, Patrick Most, Hugo A. Katus, Dierk Thomas, Patrick Lugenbiel
Publikováno v:
Physiological Reports, Vol 9, Iss 11, Pp n/a-n/a (2021)
Abstract Atrial fibrillation (AF) with concomitant heart failure (HF) poses a significant therapeutic challenge. Mechanism‐based approaches may optimize AF therapy. Small‐conductance, calcium‐activated K+ (KCa, KCNN) channels contribute to card
Externí odkaz:
https://doaj.org/article/fbc2b262d9be4cf3b001c7557d728bd1
Autor:
Ricardo O. Ramirez Flores, Jan D. Lanzer, Christian H. Holland, Florian Leuschner, Patrick Most, Jobst‐Hendrik Schultz, Rebecca T. Levinson, Julio Saez‐Rodriguez
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 7 (2021)
Background Transcriptomic studies have contributed to fundamental knowledge of myocardial remodeling in human heart failure (HF). However, the key HF genes reported are often inconsistent between studies, and systematic efforts to integrate evidence
Externí odkaz:
https://doaj.org/article/250c56dc64da4a23a16a360e0b547ec2
Autor:
Henrike Tscheschner, Eric Meinhardt, Philipp Schlegel, Andreas Jungmann, Lorenz H Lehmann, Oliver J Müller, Patrick Most, Hugo A Katus, Philip W Raake
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215992 (2019)
The clinical use of the chemotherapeutic doxorubicin (Dox) is limited by cardiotoxic side-effects. One of the early Dox effects is induction of a sarcoplasmic reticulum (SR) Ca2+ leak. The chaperone Glucose regulated protein 78 (GRP78) is important f
Externí odkaz:
https://doaj.org/article/cba7c602f18643f6a82f9c5e90c7e73f
Autor:
Dorothea Kehr, Janek Salatzki, Birgit Krautz, Karl Varadi, Jennifer Birkenstock, Philipp Schlegel, Erhe Gao, Walter J. Koch, Johannes Riffel, Florian André, Karsten Peppel, Hugo Katus, Norbert Frey, Martin Busch, Helga Pfannkuche, Julia Ritterhoff, Andreas Jungmann, Patrick Most
SummaryToxicity by recombinant adeno-associated viruses (rAAV) in clinical gene therapy trials (e.g., by rAAV9-mediated fatal liver failure) significantly impairs translation of preclinical rAAV-based cardiac gene therapies employing these vectors. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c036c1ae32f5960efd3683efb72e4ce4
https://doi.org/10.1101/2023.03.03.529004
https://doi.org/10.1101/2023.03.03.529004
Autor:
Dorothea Kehr, Julia Ritterhoff, Manuel Glaser, Lukas Jarosch, Rafael E. Salazar, Kristin Spaich, Karl Varadi, Jennifer Birkenstock, Michael Egger, Erhe Gao, Walter J. Koch, Hugo A. Katus, Norbert Frey, Andreas Jungmann, Cornelius Busch, Paul J. Mather, Arjang Ruhparwar, Mirko Völkers, Rebecca C. Wade, Patrick Most
BackgroundThe EF-hand Ca2+sensor protein S100A1 has been identified as a molecular regulator and enhancer of cardiac performance. S100A1’s ability to recognize and modulate the activity of targets such as SERCA2a and RyR2 in cardiomyocytes has most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb3004b44244dbaf42749e450e246fb
https://doi.org/10.1101/2023.03.04.531024
https://doi.org/10.1101/2023.03.04.531024
Autor:
Gabriel Hundeshagen, Viktoria Mertin, Martin Busch, Philipp Thiele, Felix Trogisch, Jörg Heineke, Michael Egger, Hannah Bürkert, Sophie van Linthout, Manuel Mayr, Jens Fielitz, Ulrich Kneser, Patrick Most, Julia Ritterhoff
Publikováno v:
Journal of Burn Care & Research. 44:S61-S62
Introduction Our clinical research unveiled chronic heart failure with preserved ejection fraction (HFpEF) as a long-term sequel in survivors of severe pediatric burn injury due to a yet unknown molecular pathomechanism. Applying a standardized rat m
Autor:
Matthias Eden, Benjamin Meder, Mirko Völkers, Montatip Poomvanicha, Katrin Domes, M. Branchereau, P. Marck, Rainer Will, Alexander Bernt, Ashraf Rangrez, Matthias Busch, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Christophe Heymes, Wolfgang Rottbauer, Patrick Most, Franz Hofmann, Norbert Frey
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel
Externí odkaz:
https://doaj.org/article/be1c405ffde14645b9a55bd92869f64e
Autor:
Zegeye H. Jebessa, Manuel Glaser, Jemmy Zhao, Andrea Schneider, Ramkumar Seenivasan, Martin Busch, Julia Ritterhoff, Rebecca C. Wade, Patrick Most
S100A1 is a small EF-type Ca2+sensor protein that belongs to the multigenic S100 protein family. It is abundantly expressed in cardiomyocytes (CMs) and has been described as a key regulator of CM performance due to its unique ability to interact with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a385ff862ffbc4aae7276472db1f07
https://doi.org/10.1101/2023.01.18.524665
https://doi.org/10.1101/2023.01.18.524665
Autor:
Tobias Jakobi, Dominik Siede, Jessica Eschenbach, Andreas W. Heumüller, Martin Busch, Rouven Nietsch, Benjamin Meder, Patrick Most, Stefanie Dimmeler, Johannes Backs, Hugo A. Katus, Christoph Dieterich
Publikováno v:
Cells, Vol 9, Iss 7, p 1616 (2020)
For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear transcript
Externí odkaz:
https://doaj.org/article/025044142ac84417ad4f3906bee829a1
Autor:
Zegeye Hailu Jebessa, Manuel Glaser, Andrea Schneider, Jemmy Zhao, Ramkumar Seenivasan, Martin Busch, Rebecca Wade, Patrick Most
Publikováno v:
Circulation Research. 131
Background & Objectives: S100A1 protein is a 10 kDa Ca 2+ sensor & abundantly expressed in cardiomyocytes (CMs) of vertebrates. Marked reduction in S100A1 level is hallmark of diseased heart, vice versa, addition of S100A1 by gene transfer rescues di