Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Patrick, Legembre"'
MMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways
Autor:
Shoji F. Kenji, Keerthi Kurma, Brigitte Collet, Christelle Oblet, Laure Debure, Carmelo Di Primo, Laëtitia Minder, Franck Vérité, Yannic Danger, Mickael Jean, Aubin Penna, Nicolas Levoin, Patrick Legembre
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-11 (2022)
Abstract CD95 is a death receptor that can promote oncogenesis through molecular mechanisms that are not fully elucidated. Although the mature CD95 membrane receptor is considered to start with the arginine at position 17 after elimination of the sig
Externí odkaz:
https://doaj.org/article/48a077bb6c494189aee69ecb73c0915b
Autor:
Sébastien Tauzin, Benjamin Chaigne-Delalande, Eric Selva, Nadine Khadra, Sophie Daburon, Cécile Contin-Bordes, Patrick Blanco, Jacques Le Seyec, Thomas Ducret, Laurent Counillon, Jean-François Moreau, Paul Hofman, Pierre Vacher, Patrick Legembre
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3002027 (2023)
[This corrects the article DOI: 10.1371/journal.pbio.1001090.].
Externí odkaz:
https://doaj.org/article/ae853f5177ab4c3da34439b79f6c7956
Autor:
Laurent Devel, Nicolas Guedeney, Sarah Bregant, Animesh Chowdhury, Mickael Jean, Patrick Legembre
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
CD95L (also known as FasL or CD178) is a member of the tumor necrosis family (TNF) superfamily. Although this transmembrane ligand has been mainly considered as a potent apoptotic inducer in CD95 (Fas)-expressing cells, more recent studies pointed ou
Externí odkaz:
https://doaj.org/article/dd73535bfe1845b39f323c06cc290558
Autor:
Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103538- (2021)
Summary: CD95 expression is preserved in triple-negative breast cancers (TNBCs), and CD95 loss in these cells triggers the induction of a pro-inflammatory program, promoting the recruitment of cytotoxic NK cells impairing tumor growth. Herein, we ide
Externí odkaz:
https://doaj.org/article/0135437ddb274417b8e1fbb80b8b4c7e
Autor:
Abdul S. Qadir, Jean Philippe Guégan, Christophe Ginestier, Assia Chaibi, Alban Bessede, Emmanuelle Charafe-Jauffret, Manon Macario, Vincent Lavoué, Thibault de la Motte Rouge, Calvin Law, Jacob Vilker, Hongbin Wang, Emily Stroup, Matthew J. Schipma, Bryan Bridgeman, Andrea E. Murmann, Zhe Ji, Patrick Legembre, Marcus E. Peter
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103348- (2021)
Summary: The apoptosis inducing receptor CD95/Fas has multiple tumorigenic activities. In different genetically engineered mouse models tumor-expressed CD95 was shown to be critical for cell growth. Using a combination of immune-deficient and immune-
Externí odkaz:
https://doaj.org/article/01c1b9341da244a5b4a9946be1c614bf
Autor:
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jérôme Estaquier, Germain Gillet, Isabelle Guénal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stéphen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernard Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Luc Poyet, Muriel Priault, Jean-Ehrland Ricci, Franck B. Riquet, Santos A. Susin, Magali Suzanne, Pierre Vacher, Ludivine Walter, Bertrand Mollereau
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 901 (2022)
Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although ma
Externí odkaz:
https://doaj.org/article/a7116fd2eb2845b5911a169d405c21e9
Autor:
Eva Szegezdi, Patrick Legembre
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/426a4a5f092c4da4a991c42a6acb6c9c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its ligand CD95L brings to a next level its aggregation and triggers different signaling pathways, leading to cell motility, differentiation or cell death. This diversi
Externí odkaz:
https://doaj.org/article/3776074b1d384be3a5054b40252c84e0
Publikováno v:
Cells, Vol 11, Iss 9, p 1438 (2022)
Study of the initial steps of the CD95-mediated signaling pathways is a field of intense research and a long list of actors has been described in the literature. Nonetheless, the dynamism of protein-protein interactions (PPIs) occurring in the presen
Externí odkaz:
https://doaj.org/article/9e7e3b9537224c929ebcf381fab26c90
Autor:
Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel
Externí odkaz:
https://doaj.org/article/397f4e630bac42c587fdf199a5689e3f