Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Patrick, Leclerc"'
Autor:
Robert D. Inman, Denis Choquette, Majed Khraishi, Dafna D. Gladman, Shamiza Hussein, Drew Neish, Patrick Leclerc
Publikováno v:
The Journal of Rheumatology. 50:634-640
ObjectiveAxial spondyloarthritis (axSpA) is a chronic, immune-mediated, inflammatory condition consisting of 2 clinical subsets: nonradiographic axSpA and ankylosing spondylitis, the latter having an estimated prevalence of 0.2% to 1% in Canada. Secu
Autor:
Dafna D. Gladman, Denis Choquette, Majed Khraishi, Robert D. Inman, Shamiza Hussein, Drew Neish, Patrick Leclerc
Publikováno v:
The Journal of Rheumatology. 50:641-648
ObjectivePsoriatic arthritis (PsA) is an immune-mediated disease characterized by pain, stiffness, and swelling of peripheral joints, with an estimated prevalence in Canada of 0.45%. Treatment aims to minimize disease activity, reduce progression of
Autor:
Robert D. Inman, Marco Garrido-Cumbrera, Jonathan Chan, Martin Cohen, Artur J. de Brum-Fernandes, Wendy Gerhart, Nigil Haroon, Algis V. Jovaisas, Gerald Major, Michael G. Mallinson, Sherry Rohekar, Patrick Leclerc, Proton Rahman
Publikováno v:
The Journal of Rheumatology. 50:625-633
ObjectiveTo identify factors associated with work-related issues in Canadian patients with axial spondyloarthritis.MethodsData from 542 Canadian patients who participated in the International Map of Axial Spondyloarthritis online survey were analyzed
Autor:
Dafna, Gladman, Denis, Choquette, Majed, Khraishi, Robert, Inman, Shamiza, Hussein, Drew, Neish, Patrick, Leclerc
Publikováno v:
The Journal of rheumatology.
Psoriatic arthritis (PsA) is an immune-mediated disease characterized by pain, stiffness, and swelling of peripheral joints, with an estimated prevalence in Canada of 0.45%. Treatment aims to minimize disease activity, reduce progression of damage, a
Autor:
Robert D, Inman, Marco, Garrido-Cumbrera, Jonathan, Chan, Martin, Cohen, Artur J, de Brum-Fernandes, Wendy, Gerhart, Nigil, Haroon, Algis V, Jovaisas, Gerald, Major, Michael G, Mallinson, Sherry, Rohekar, Patrick, Leclerc, Proton, Rahman
Publikováno v:
The Journal of rheumatology.
To identify factors associated with work-related issues in Canadian patients with axial spondyloarthritis (axSpA).Data from 542 Canadian patients who participated in the International Map of Axial Spondyloarthritis (IMAS) online survey were analysed.
Autor:
Maria J H de Hair, Patrick Leclerc, Elize C Newsum, Karen I Maijer, Marleen G H van de Sande, Tamara H Ramwadhdoebe, Dirkjan van Schaardenburg, Lisa G M van Baarsen, Marina Korotkova, Danielle M Gerlag, Paul-Peter Tak, Per-Johan Jakobsson
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133669 (2015)
Arthralgia may precede the development of synovial inflammation in autoantibody-positive individuals at risk of developing rheumatoid arthritis (RA). A major pathway involved in pain is the prostaglandin (PG) E2 pathway. We investigated this pathway
Externí odkaz:
https://doaj.org/article/e356b88270344edea624e999999c26e9
Autor:
Patrick Leclerc, Jordane Biarc, Mireille St-Onge, Caroline Gilbert, Andrée-Anne Dussault, Cynthia Laflamme, Marc Pouliot
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2229 (2008)
The inducible cyclooxygenase isoform (COX-2) is associated with inflammation, tumorigenesis, as well as with physiological events. Despite efforts deployed in order to understand the biology of this multi-faceted enzyme, much remains to be understood
Externí odkaz:
https://doaj.org/article/03dab4cf345c473091663b2d5f92e158
Autor:
Marina Korotkova, Petter Olsson, Per-Johan Jakobsson, Joan Raouf, Patrick Leclerc, Helena Idborg
Publikováno v:
Prostaglandins & Other Lipid Mediators. 107:18-25
mPGES-1 is considered an alternative target for anti-inflammatory treatment with improved selectivity and safety compared to NSAIDs. mPGES-1 depletion not only suppresses inflammation via absence of inducible PGE2 but might also cause an activation o
Autor:
Per-Johan Jakobsson, Natalia Nekhotiaeva, Linda Spahiu, Marina Korotkova, Charlotte Larsson, Helena Idborg, Patrick Leclerc, Patric Stenberg, Johan Wannberg
Publikováno v:
Prostaglandins & Other Lipid Mediators. 107:26-34
Microsomal prostaglandin E synthase-1 (mPGES-1) inhibition has been suggested as an alternative to cyclooxygenase (COX) inhibition in the treatment of pain and inflammation. We characterized a selective inhibitor of mPGES-1 activity (compound III) an
Autor:
Jonatan Tuncel, Stefan Lange, Robert A. Harris, Monica Marta, Tao Jin, Maja Jagodic, Rikard Holmdahl, Alan Gillett, Tomas Olsson, Patrick Leclerc, Rita Nohra
Publikováno v:
The Journal of Immunology. 185:442-450
Dysregulation of TNF is an important pathophysiological phenotype for many diseases. Recently, certain genetically regulated loci have been identified to regulate several inflammatory diseases. We hypothesized that a region on rat chromosome 4 known