Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Patrick, Giavalisco"'
Autor:
Abhishek Aich, Angela Boshnakovska, Steffen Witte, Tanja Gall, Kerstin Unthan-Fechner, Roya Yousefi, Arpita Chowdhury, Drishan Dahal, Aditi Methi, Svenja Kaufmann, Ivan Silbern, Jan Prochazka, Zuzana Nichtova, Marcela Palkova, Miles Raishbrook, Gizela Koubkova, Radislav Sedlacek, Simon E. Tröder, Branko Zevnik, Dietmar Riedel, Susann Michanski, Wiebke Möbius, Philipp Ströbel, Christian Lüchtenborg, Patrick Giavalisco, Henning Urlaub, Andre Fischer, Britta Brügger, Stefan Jakobs, Peter Rehling
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since c
Externí odkaz:
https://doaj.org/article/fbb1f03201784bd1bc12298332352d79
Autor:
Soyoung Park, Amine M. Belfoul, Marialetizia Rastelli, Alice Jang, Magali Monnoye, Hosung Bae, Anna Kamitakahara, Patrick Giavalisco, Shan Sun, Pierre-Yves Barelle, Jasmine Plows, Cholsoon Jang, Anthony Fodor, Michael I. Goran, Sebastien G. Bouret
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
The prevalence of obesity and type 2 diabetes is growing at an alarming rate, including among pregnant women. Low-calorie sweeteners (LCSs) have increasingly been used as an alternative to sugar to deliver a sweet taste without the excessive caloric
Externí odkaz:
https://doaj.org/article/9fd41721090b47e2b3f76dbe4fd2ee90
Autor:
Pablo Rivera-Mejías, Álvaro Jesús Narbona-Pérez, Lidwina Hasberg, Lara Kroczek, Amir Bahat, Steffen Lawo, Kat Folz-Donahue, Anna-Lena Schumacher, Sofia Ahola, Fiona Carola Mayer, Patrick Giavalisco, Hendrik Nolte, Sergio Lavandero, Thomas Langer
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112332- (2023)
Summary: The metabolic plasticity of mitochondria ensures cell development, differentiation, and survival. The peptidase OMA1 regulates mitochondrial morphology via OPA1 and stress signaling via DELE1 and orchestrates tumorigenesis and cell survival
Externí odkaz:
https://doaj.org/article/5e2ae9642b664f2ca3c93a043e5f99f6
Autor:
Fabio Simeoni, Aleksandra Skirycz, Laura Simoni, Giulia Castorina, Leonardo Perez de Souza, Alisdair R. Fernie, Saleh Alseekh, Patrick Giavalisco, Lucio Conti, Chiara Tonelli, Massimo Galbiati
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Stomata are epidermal pores formed by pairs of specialized guard cells, which regulate gas exchanges between the plant and the atmosphere. Modulation of transcription has emerged as an important level of regulation of stomatal activity. The
Externí odkaz:
https://doaj.org/article/a6929d058db34ec5a480b26aeba45989
Autor:
María C. Dalmasso, Martín Arán, Pablo Galeano, Silvina Perin, Patrick Giavalisco, Pamela V. Martino Adami, Gisela V. Novack, Eduardo M. Castaño, A. Claudio Cuello, Martin Scherer, Wolfgang Maier, Michael Wagner, Steffi Riedel-Heller, Alfredo Ramirez, Laura Morelli
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Introduction: The metabolic routes altered in Alzheimer's disease (AD) brain are poorly understood. As the metabolic pathways are evolutionarily conserved, the metabolic profiles carried out in animal models of AD could be directly translated into hu
Externí odkaz:
https://doaj.org/article/c97efebf6eb0455290958f433544b64d
Autor:
Nils C. Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Robert Lorenz Chua, Jakob Trimpert, Nicolas Heinemann, Christine Niemeyer, Friderike Weege, Katja Hönzke, Tom Aschman, Daniel E. Heinz, Katja Weckmann, Tim Ebert, Andreas Zellner, Martina Lennarz, Emanuel Wyler, Simon Schroeder, Anja Richter, Daniela Niemeyer, Karen Hoffmann, Thomas F. Meyer, Frank L. Heppner, Victor M. Corman, Markus Landthaler, Andreas C. Hocke, Markus Morkel, Nikolaus Osterrieder, Christian Conrad, Roland Eils, Helena Radbruch, Patrick Giavalisco, Christian Drosten, Marcel A. Müller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Externí odkaz:
https://doaj.org/article/a210cbf8766241fd8d824076b3b287b5
Autor:
Désirée Schatton, Giada Di Pietro, Karolina Szczepanowska, Matteo Veronese, Marie-Charlotte Marx, Kristina Braunöhler, Esther Barth, Stefan Müller, Patrick Giavalisco, Thomas Langer, Aleksandra Trifunovic, Elena I Rugarli
Publikováno v:
eLife, Vol 11 (2022)
Proliferating cells undergo metabolic changes in synchrony with cell cycle progression and cell division. Mitochondria provide fuel, metabolites, and ATP during different phases of the cell cycle, however it is not completely understood how mitochond
Externí odkaz:
https://doaj.org/article/9ae815e02e694cba80408f4eb523b738
Autor:
Vita Stepanova, Kaja Ewa Moczulska, Guido N Vacano, Ilia Kurochkin, Xiangchun Ju, Stephan Riesenberg, Dominik Macak, Tomislav Maricic, Linda Dombrowski, Maria Schörnig, Konstantinos Anastassiadis, Oliver Baker, Ronald Naumann, Ekaterina Khrameeva, Anna Vanushkina, Elena Stekolshchikova, Alina Egorova, Anna Tkachev, Randall Mazzarino, Nathan Duval, Dmitri Zubkov, Patrick Giavalisco, Terry G Wilkinson, David Patterson, Philipp Khaitovich, Svante Pääbo
Publikováno v:
eLife, Vol 10 (2021)
We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other
Externí odkaz:
https://doaj.org/article/fd1a3282c2934c4483b85c46f214b2b5
Autor:
Shahar Barbash, Benjamin P. Garfinkel, Rotem Maoz, Alon Simchovitz, Bettina Nadorp, Alessandro Guffanti, Estelle R. Bennett, Courtney Nadeau, Andreas Türk, Lukas Paul, Torsten Reda, Yan Li, Aron S. Buchman, David S. Greenberg, Alexander Seitz, David A. Bennett, Patrick Giavalisco, Hermona Soreq
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 1-13 (2017)
Alzheimer's disease (AD) involves changes in both lipid and RNA metabolism, but it remained unknown if these differences associate with AD's cognition and/or post-mortem neuropathology indices. Here, we report RNA-sequencing evidence of inter-related
Externí odkaz:
https://doaj.org/article/1e0cbf0e88b14e949171a39da1b8c4ee
Autor:
Patrizia Hanhart, Melanie Thieß, Khalid Amari, Krzysztof Bajdzienko, Patrick Giavalisco, Manfred Heinlein, Julia Kehr
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Cyclophilins (CYPs) are a group of ubiquitous proteins characterized by their ability to bind to the immunosuppressive drug cyclosporin A. The CYP family occurs in a wide range of organisms and contains a conserved peptidyl-prolyl cis/trans
Externí odkaz:
https://doaj.org/article/104ad6a317d944bf814a34765805b572