Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Patrick, Chames"'
Autor:
Antonio Tapia-Galisteo, Iñigo Sánchez-Rodríguez, Javier Narbona, Patricia Iglesias-Hernández, Saray Aragón-García, Anaïs Jiménez-Reinoso, Marta Compte, Shaukat Khan, Takeshi Tsuda, Patrick Chames, Javier Lacadena, Luis Álvarez-Vallina, Laura Sanz
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
T cell-based immunotherapies for solid tumors have not achieved the clinical success observed in hematological malignancies, partially due to the immunosuppressive effect promoted by the tumor microenvironment, where PD-L1 and TGF-β play a pivotal r
Externí odkaz:
https://doaj.org/article/3126feeb469c436b90c0b4d00590133a
Autor:
Nicolas De Leiris, Pascale Perret, Charlotte Lombardi, Bülent Gözel, Sabine Chierici, Philippe Millet, Marlène Debiossat, Sandrine Bacot, Benjamin B. Tournier, Patrick Chames, Jean-Luc Lenormand, Catherine Ghezzi, Daniel Fagret, Marcelle Moulin
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation of Tau pathology in Alzheimer’s disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 as a novel radiotra
Externí odkaz:
https://doaj.org/article/1ac0048706c44dee9da004630017f449
Autor:
Abdennour Benloucif, Damien Meyer, Laure Balasse, Armelle Goubard, Lucile Danner, Ahlem Bouhlel, Rémy Castellano, Benjamin Guillet, Patrick Chames, Brigitte Kerfelec
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMesothelin (MSLN) is overexpressed in a wide variety of cancers with few therapeutic options and has recently emerged as an attractive target for cancer therapy, with a large number of approaches currently under preclinical and clinical i
Externí odkaz:
https://doaj.org/article/262bbe933e284b5b9bd890fcc4892a92
Autor:
Antonio Tapia-Galisteo, Íñigo Sánchez Rodríguez, Oscar Aguilar-Sopeña, Seandean Lykke Harwood, Javier Narbona, Mariola Ferreras Gutierrez, Rocío Navarro, Laura Martín-García, Cesáreo Corbacho, Marta Compte, Javier Lacadena, Francisco J. Blanco, Patrick Chames, Pedro Roda-Navarro, Luis Álvarez-Vallina, Laura Sanz
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Retargeting of T lymphocytes toward cancer cells by bispecific antibodies has demonstrated its therapeutic potential, with one such antibody approved for the treatment of acute lymphoblastic leukemia (blinatumomab) and several other in clinical trial
Externí odkaz:
https://doaj.org/article/50e1a9f6bc804a1eacd6d85e57eda00b
Autor:
Adeline Raynaud, Klervi Desrumeaux, Laurent Vidard, Elise Termine, Daniel Baty, Patrick Chames, Emmanuelle Vigne, Brigitte Kerfelec
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
The natural killer group 2 member D (NKG2D) receptor is a C-type lectin-like activating receptor mainly expressed by cytotoxic immune cells including NK, CD8+ T, γδ T and NKT cells and in some pathological conditions by a subset of CD4+ T cells. It
Externí odkaz:
https://doaj.org/article/f449edcc141444e58bd0fbc7c6c121f7
Autor:
Ashley L. Kiemen, Alexander Ioannis Damanakis, Alicia M. Braxton, Jin He, Daniel Laheru, Elliot K. Fishman, Patrick Chames, Cristina Almagro Pérez, Pei-Hsun Wu, Denis Wirtz, Laura D. Wood, Ralph H. Hruban
Publikováno v:
Med
Med, 2023, 4 (2), pp.75-91. ⟨10.1016/j.medj.2022.11.009⟩
Med, 2023, 4 (2), pp.75-91. ⟨10.1016/j.medj.2022.11.009⟩
International audience; Pancreatic cancer is currently the third leading cause of cancer death in the United States. The clinical hallmarks of this disease include abdominal pain that radiates to the back, the presence of a hypoenhancing intrapancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8089e09d077e7593a6f77425e82bb358
https://doi.org/10.1016/j.medj.2022.11.009
https://doi.org/10.1016/j.medj.2022.11.009
Autor:
Franziska Hartung, Thomas Krüwel, Xiaoyi Shi, Klaus Pfizenmaier, Roland Kontermann, Patrick Chames, Frauke Alves, Luis A. Pardo
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Antibody-based therapies hold promise for a safe and efficient treatment of cancer. The identification of target tumor cells through a specific antigen enriched on their surface and the subsequent delivery of the therapeutic agent only to those cells
Externí odkaz:
https://doaj.org/article/8a17bf723c6c4c479977eba27d884887
Autor:
Fernanda Ramos-Gomes, Julia Bode, Alyona Sukhanova, Svetlana V. Bozrova, Mara Saccomano, Miso Mitkovski, Julia Eva Krueger, Anja K. Wege, Walter Stuehmer, Pavel S. Samokhvalov, Daniel Baty, Patrick Chames, Igor Nabiev, Frauke Alves
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Early detection of malignant tumours and, especially, micrometastases and disseminated tumour cells is still a challenge. In order to implement highly sensitive diagnostic tools we demonstrate the use of nanoprobes engineered from nanobodies
Externí odkaz:
https://doaj.org/article/31f241baea3d44148c2b495267e0f415
Autor:
Pauline Scholler, Damien Nevoltris, Dimitri de Bundel, Simon Bossi, David Moreno-Delgado, Xavier Rovira, Thor C. Møller, Driss El Moustaine, Michaël Mathieu, Emilie Blanc, Heather McLean, Elodie Dupuis, Gérard Mathis, Eric Trinquet, Hervé Daniel, Emmanuel Valjent, Daniel Baty, Patrick Chames, Philippe Rondard, Jean-Philippe Pin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
G protein-coupled receptors are considered promising therapeutic targets. Here, the authors have identified nanobodies, or single-domain llama antibodies, that specifically enhance agonist-induced activity of a type of G protein-coupled receptor, the
Externí odkaz:
https://doaj.org/article/816648732d614ed3bfb0746f18dd9438
Autor:
Joanie Del Bano, Rémy Florès-Florès, Emmanuelle Josselin, Armelle Goubard, Laetitia Ganier, Rémy Castellano, Patrick Chames, Daniel Baty, Brigitte Kerfelec
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment options. Mesothelin is a glycosyl-phosphatidyl inositol-linked membrane protein with restricted normal expression and high level expres
Externí odkaz:
https://doaj.org/article/e903097211f846678847b4f060e65053