Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Patricia W. Tynan"'
Autor:
Frances M. Platt, David Smith, Lauren Morris, Oscar C. W. Chen, Lianne C. Davis, Alexandria Colaco, Emily R. Eden, Forbes D. Porter, Patricia W. Tynan, Fedir N Kiskin, Anneliese O. Speak, Grant C. Churchill, Nicole Y. Farhat, Antony Galione
Publikováno v:
JIMD Reports, Vol 56, Iss 1, Pp 46-57 (2020)
JIMD Reports
JIMD Reports
Niemann‐Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder caused by mutations in either NPC1 (95% of cases) or NPC2. Reduced late endosome/lysosome calcium (Ca2+) levels and the accumulation of unesterified cholesterol and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf5d7b8717f1babb1787871291c7958
https://doaj.org/article/0e1a6412d2a14de1a7841b940a26ea33
https://doaj.org/article/0e1a6412d2a14de1a7841b940a26ea33
Autor:
Simon Clark, Anthony J. Morgan, Raju V. V. Tatituri, Emyr Lloyd-Evans, Lianne C. Davis, Frances M. Platt, Edith Sim, Nick Platt, David G. Russell, Doris Höglinger, Nathan A. Lack, Evgeniya V. Nazarova, Ann Williams, Paul Fineran, Nada Al Eisa, Patricia W. Tynan, Gurdyal S. Besra, Daniel S. Ory, Antony Galione, Ian M. Williams, Michael B. Brenner
Publikováno v:
Turkish Journal of Urology
Wellcome Open Research
Wellcome Open Research
Background. Tuberculosis remains a major global health concern. The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term persistence within host c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b936f9b841946ac13015e400844a45e2
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/2903
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/2903
Autor:
Margarida, Ruas, Kai-Ting, Chuang, Lianne C, Davis, Areej, Al-Douri, Patricia W, Tynan, Ruth, Tunn, Lydia, Teboul, Antony, Galione, John, Parrington
Publikováno v:
Molecular and Cellular Biology
Organelle ion homeostasis within the endo-lysosomal system is critical for physiological functions. Two-pore channels (TPCs) are cation channels that reside in endo-lysosomal organelles, and overexpression results in endo-lysosomal trafficking defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9c3d1ca1e9a3b479ca06f4717f9b65e0
http://europepmc.org/articles/PMC4386455
http://europepmc.org/articles/PMC4386455
Autor:
Tobias Langenhan, Patricia W. Tynan, Christopher Yau, Peter Donnelly, Nigel J. Emptage, Helen C. Christian, Ruth D. T. Taylor, Chanel Taylor, Lindsay McGuinness, Michael Hart
Publikováno v:
Neuron. 68:1109-1127
A rise in [Ca(2+)](i) provides the trigger for neurotransmitter release at neuronal boutons. We have used confocal microscopy and Ca(2+) sensitive dyes to directly measure the action potential-evoked [Ca(2+)](i) in the boutons of Schaffer collaterals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58328e5c56c051a53166ed8d60722bac
https://doi.org/10.1016/j.neuron.2010.11.023
https://doi.org/10.1016/j.neuron.2010.11.023
Autor:
Tomás García-Caballero, Helen C. Christian, David González-Touceda, Begona Porteiro Couto, Iain P. Hargreaves, John Parrington, Pamela V. Lear, Vanessa Guymer, Carlos Dieguez, Patricia Viaño, Elena Remzova, Patricia W. Tynan, Ruth Tunn, Rubén Nogueiras, Annapurna Chalasani
Publikováno v:
Endocrinology. 156(3)
Intracellular calcium-permeable channels have been implicated in thermogenic function of murine brown and brite/beige adipocytes, respectively transient receptor potential melastin-8 and transient receptor potential vanilloid-4. Because the endo-lyso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32f9264a7587ffdd9bfea0dcc055890
https://pubmed.ncbi.nlm.nih.gov/25545384
https://pubmed.ncbi.nlm.nih.gov/25545384