Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Patricia W. Greenwell"'
Autor:
Wei Tang, Margaret Dominska, Patricia W Greenwell, Zachary Harvanek, Kirill S Lobachev, Hyun-Min Kim, Vidhya Narayanan, Sergei M Mirkin, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001270 (2011)
Expansions of trinucleotide GAA•TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA•TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)•(TTC)(230) stimulate mitotic crossovers in yeas
Externí odkaz:
https://doaj.org/article/59adf8cdebcf42908eafed207a85a711
Autor:
Phoebe S Lee, Patricia W Greenwell, Margaret Dominska, Malgorzata Gawel, Monica Hamilton, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000410 (2009)
Homologous recombination is an important mechanism for the repair of DNA damage in mitotically dividing cells. Mitotic crossovers between homologues with heterozygous alleles can produce two homozygous daughter cells (loss of heterozygosity), whereas
Externí odkaz:
https://doaj.org/article/bf248ebbb82946d3a0e29a1a76d46f24
Autor:
Thomas D. Petes, Margaret Dominska, Anthony Moore, Sergei M. Mirkin, Patricia W. Greenwell, Anna Y. Aksenova
Publikováno v:
Genetics
In many organisms, telomeric sequences can be located internally on the chromosome in addition to their usual positions at the ends of the chromosome. In humans, such interstitial telomeric sequences (ITSs) are nonrandomly associated with translocati
Autor:
Margaret Dominska, Alexander A. Shishkin, Thomas D. Petes, Anna Y. Aksenova, Jane C. Kim, Patricia W. Greenwell, Sergei M. Mirkin
Publikováno v:
Proceedings of the National Academy of Sciences. 110:19866-19871
Interstitial telomeric sequences (ITSs) are present in many eukaryotic genomes and are linked to genome instabilities and disease in humans. The mechanisms responsible for ITS-mediated genome instability are not understood in molecular detail. Here,
Autor:
Patricia W. Greenwell, Wei Song, Margaret Dominska, Thomas D. Petes, Kerry Bloom, Einat Hazkani-Covo, Malgorzata Gawel
Publikováno v:
Genetics
Dicentric chromosomes undergo breakage in mitosis, resulting in chromosome deletions, duplications, and translocations. In this study, we map chromosome break sites of dicentrics in Saccharomyces cerevisiae by a mitotic recombination assay. The assay
Autor:
Wei Song, Christopher M. Puccia, Piotr A. Mieczkowski, Ewa P. Malc, Juan Lucas Argueso, Ane Fernanda Beraldi Zeidler, Thomas D. Petes, Hengshan Zhang, Patricia W. Greenwell
Publikováno v:
Genetics. 193:785-801
The increasing ability to sequence and compare multiple individual genomes within a species has highlighted the fact that copy-number variation (CNV) is a substantial and underappreciated source of genetic diversity. Chromosome-scale mutations occur
Publikováno v:
DNA Repair. 12:10-17
Expansion of certain trinucleotide repeats causes several types of human diseases, and such tracts are associated with the formation of deletions and other types of genetic rearrangements in Escherichia coli, yeast, and mammalian cells. Below, we sho
Publikováno v:
Genetics. 183:423-439
Genetic instability at palindromes and spaced inverted repeats (IRs) leads to chromosome rearrangements. Perfect palindromes and IRs with short spacers can extrude as cruciforms or fold into hairpins on the lagging strand during replication. Crucifor
Autor:
Thomas D. Petes, Wei Du, Cheng-Sheng Lee, Ranjith P. Anand, James E. Haber, Patricia W. Greenwell, Olga Tsaponina
Publikováno v:
Genesdevelopment. 28(21)
Recent high-resolution genome analyses of cancer and other diseases have revealed the occurrence of microhomology-mediated chromosome rearrangements and copy number changes. Although some of these rearrangements appear to involve nonhomologous end-jo
Publikováno v:
Journal of Biological Chemistry. 280:4264-4269
Activation of phospholipase C-dependent inositol polyphosphate signaling pathways generates distinct messengers derived from inositol 1,4,5-trisphosphate that control gene expression and mRNA export. Here we report the regulation of telomere length b