Výsledky vyhledávání - "Patricia W Pan"

Akademický článek

Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.

Autor: Jing Li, Zhihong Li, Jianbin Ruan, Chao Xu, Yufeng Tong, Patricia W Pan, Wolfram Tempel, Lissete Crombet, Jinrong Min, Jianye Zang

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25104 (2011)

M-phase phosphoprotein 8 (MPP8) was initially identified to be a component of the RanBPM-containing large protein complex, and has recently been shown to bind to methylated H3K9 both in vivo and in vitro. MPP8 binding to methylated H3K9 is suggested

Externí odkaz: https://doaj.org/article/e45b3e5623ce4eab9a939f9ddbfff167

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Akademický článek

Structural and chemical profiling of the human cytosolic sulfotransferases.

Autor: Abdellah Allali-Hassani, Patricia W Pan, Ludmila Dombrovski, Rafael Najmanovich, Wolfram Tempel, Aiping Dong, Peter Loppnau, Fernando Martin, Janet Thornton, Aled M Edwards, Alexey Bochkarev, Alexander N Plotnikov, Masoud Vedadi, Cheryl H Arrowsmith

Publikováno v: PLoS Biology, Vol 5, Iss 5, p e97 (2007)

The human cytosolic sulfotransfases (hSULTs) comprise a family of 12 phase II enzymes involved in the metabolism of drugs and hormones, the bioactivation of carcinogens, and the detoxification of xenobiotics. Knowledge of the structural and mechanist

Externí odkaz: https://doaj.org/article/b16aa60a578740d2ac8dcb3a1c09342a

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Structure and Biochemical Functions of SIRT6

Autor: Mark K. Devries, Jessica L. Feldman, Aled M. Edwards, Patricia W. Pan, John M. Denu, Aiping Dong

Publikováno v: Journal of Biological Chemistry. 286:14575-14587

SIRT6 is a member of the evolutionarily conserved sirtuin family of NAD(+)-dependent protein deacetylases and functions in genomic stability and transcriptional control of glucose metabolism. Early reports suggested that SIRT6 performs ADP-ribosylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dc518379d89062506a5b5b503cd7bf
https://doi.org/10.1074/jbc.m111.218990

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Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2

Autor: Abdellah Allali-Hassani, Yahong Guo, Masoud Vedadi, Chao Qi, Jinrong Min, Patricia W. Pan, Nataliya Nady, Matthieu Schapira, Maria F. Amaya, Cheryl H. Arrowsmith, Aiping Dong, Randy J. Read, Melanie A. Adams-Cioaba, Haizhong Zhu

Publikováno v: Nucleic Acids Research

The MBT repeat has been recently identified as a key domain capable of methyl-lysine histone recognition. Functional work has pointed to a role for MBT domain-containing proteins in transcriptional repression of developmental control genes such as Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d95e40c0306214570b7727a19d116a
http://europepmc.org/articles/PMC2673432

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Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family

Autor: Cheryl H. Arrowsmith, Masoud Vedadi, Ludmila Dombrovsky, Alexander N. Plotnikov, Richard J. Morris, Abdellah Allali-Hassani, Aled M. Edwards, Patricia W. Pan, Rafael Najmanovich, Janet M. Thornton

Publikováno v: Bioinformatics. 23:e104-e109

Motivation: In the present work we combine computational analysis and experimental data to explore the extent to which binding site similarities between members of the human cytosolic sulfotransferase family correlate with small-molecule binding prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad8c939f6da3e15472c34812ce5aa46
https://doi.org/10.1093/bioinformatics/btl292

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Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9

Autor: Lissete Crombet, Chao Xu, Wolfram Tempel, Jianye Zang, Jing Li, Patricia W. Pan, Yufeng Tong, Zhihong Li, Jinrong Min, Jianbin Ruan

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25104 (2011)
PLoS ONE

Background M-phase phosphoprotein 8 (MPP8) was initially identified to be a component of the RanBPM-containing large protein complex, and has recently been shown to bind to methylated H3K9 both in vivo and in vitro. MPP8 binding to methylated H3K9 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f551bdf4f0169bbc2508b38e6daa3ebd
http://europepmc.org/articles/PMC3192050?pdf=render

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Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

Autor: Chen Chen, Chao Xu, Huadong Liu, Hengbin Wang, Wei Yang, Marek Galka, Hui Ouyang, Chuanbing Bian, Shawn S.-C. Li, Wei Qiu, Farrell MacKenzie, Patricia W. Pan, Amanda Jones, Jinrong Min

Publikováno v: Biochemistry Publications

The polycomb repressive complex 2 (PRC2) is the major methyltransferase for H3K27 methylation, a modification critical for maintaining repressed gene expression programs throughout development. It has been previously shown that PRC2 maintains histone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c01e16def53af1d23d60f91f3f55929
https://pubmed.ncbi.nlm.nih.gov/20974918

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MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1

Autor: Lipeng Wu, Callie A.S. Corsa, Jinrong Min, Patricia W. Pan, Xiaochun Yu, Yali Dou, Xiangzhi Li, David J. P. Ferguson

Publikováno v: Molecular and cellular biology. 30(22)

MOF (MYST1) is the major enzyme to catalyze acetylation of histone H4 lysine 16 (K16) and is highly conserved through evolution. Using a conditional knockout mouse model and the derived mouse embryonic fibroblast cell lines, we showed that loss of Mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d75fce86666a1ed4abd83ef132e8cc
https://pubmed.ncbi.nlm.nih.gov/20837706

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Structural and chemical profiling of the human cytosolic sulfotransferases

Autor: Peter Loppnau, Abdellah Allali-Hassani, Fernando Martin, Rafael Najmanovich, Wolfram Tempel, Cheryl H. Arrowsmith, Janet Thonton, Alexander N. Plotnikov, Alexey Bochkarev, Ludmila Dombrovski, Masoud Vedadi, Aled M. Edwards, Janet M. Thornton, Aiping Dong, Patricia W. Pan

Publikováno v: PLoS Biology
PLoS Biology, Vol 5, Iss 5, p e97 (2007)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d032fc9428ce4ae2ca4c2ace64bdc0a0
https://pubmed.ncbi.nlm.nih.gov/17425406

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Structural Studies of a Four-MBT Repeat Protein MBTD1

Autor: Jinrong Min, Jitka Eryilmaz, Maria F. Amaya, Aiping Dong, Abdellah Allali-Hassani, Masoud Vedadi, Patricia W. Pan, Farrell MacKenzie, Melanie A. Adams-Cioaba

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7274 (2009)
PLoS ONE

Background: The Polycomb group (PcG) of proteins is a family of important developmental regulators. The respective members function as large protein complexes involved in establishment and maintenance of transcriptional repression of developmental co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b7b0976494a8612d072141efe0212c
https://doi.org/10.1371/journal.pone.0007274

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