Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Patricia Thiemann"'
3
Synthesis and Anticancer Properties of Water-Soluble Zinc Ionophores
Autor: Zhong Wang, Wenhao Wei, Vincent M. Lynch, Xiaoming Wang, Weilin Hu, Patricia Thiemann, Xuan Ma, Philip Lecane, Patricia K. Dranchak, Jonathan L. Sessler, Viktor Csokai, Darren Magda, Joseph G. Hacia
Publikováno v: Cancer Research. 68:5318-5325
Several water-solubilized versions of the zinc ionophore 1-hydroxypyridine-2-thione (ZnHPT), synthesized as part of the present study, have been found both to increase the intracellular concentrations of free zinc and to produce an antiproliferative
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12e6c3b01d7d156459ae761b99aad3a
https://doi.org/10.1158/0008-5472.can-08-0601
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4
mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft
Autor: Julia Prescott, Krishna Ramaswamy, Darren Magda, Xuan Ma, Patricia Thiemann, Philip Lecane, Kimberly D. Siegmund, Joseph G. Hacia, Patricia K. Dranchak, Donna M Toleno
Publikováno v: BMC Genomics, Vol 9, Iss 1, p 521 (2008)
BMC Genomics
Background Interactions between the gene products encoded by the mitochondrial and nuclear genomes play critical roles in eukaryotic cellular function. However, the effects mitochondrial DNA (mtDNA) levels have on the nuclear transcriptome have not b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7ce3f1d5b676ff95d4fa154e9ab697
http://www.biomedcentral.com/1471-2164/9/521
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5
Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression
Autor: Samantha M. Yeligar, Zhong Wang, Brian L. Pike, Patricia Thiemann, Dong-Gyu Cho, Xuan Ma, Dale Miles, Mazen W. Karaman, Philip Lecane, Danielle Tonev, Jonathan L. Sessler, Joseph G. Hacia, Richard A. Miller, Qing Fan, Darren Magda, Louie Naumovski, Cecilia Cortez
Publikováno v: Molecular Cancer
Molecular Cancer, Vol 6, Iss 1, p 9 (2007)
Background Sapphyrin analogues and related porphyrin-like species have attracted attention as anticancer agents due to their selective localization in various cancers, including hematologic malignancies, relative to surrounding tissues. Sapphyrins ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e86a231bc148551d5719d48b985459
https://doi.org/10.1186/1476-4598-6-9
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6
Enhancement of lutetium texaphyrin phototherapy with Mitomycin C
Autor: Kathryn W. Woodburn, Patricia Thiemann
Publikováno v: SPIE Proceedings.
Lutetium texaphyrin (Lu-Tex) photodynamic therapy (PDT) relies on the presence of the water-soluble Lu-Tex, oxygen, and light (activation around 730 nm). Cytotoxic oxygen species are produced that cause irreversible damage to biological substrates. D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf96766b873163c9fe948b10407b3745
https://doi.org/10.1117/12.308131
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7
Light-emitting diode versus laser irradiation phototherapy with lutetium texaphyrin (PCI-0123)
Autor: Patricia Thiemann, Dale R. Miles, Fan Qing, Kathryn W. Woodburn, Stuart W. Young
Publikováno v: SPIE Proceedings.
Lutetium texaphyrin (PCI-0123) is presently in clinical trials for the treatment of neoplasms. An argon-pumped dye laser has mostly been used to generate light for PCI-0123 photoactivation. However, lasers are expensive and produce a limited area of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dce80072e0ba197f7ba348628aad6de1
https://doi.org/10.1117/12.273486
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8
Feasibility of repeated sequential treatments of RIF-1 tumors with photodynamic therapy (PDT) using lutetium texaphyrin (PCI-0123)
Autor: Dale R. Miles, Lynn M. Parker, Kathryn W. Woodburn, Stuart W. Young, Patricia Thiemann
Publikováno v: SPIE Proceedings.
Lutetium texaphyrin (PCI-0123) is currently in clinical trials as a PDT agent for the treatment of cancer patients. The drug is cleared rapidly from the plasma, and photoirradiation can be performed shortly after drug administration.T He photosensiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::810558ba432016aa59824d4d366706ae
https://doi.org/10.1117/12.273485
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9
Abstract 923: Ibrutinib inhibits malignant cell adhesion and migration and reduces tumor burden in lymph node and bone marrow in a murine model of mantle cell dissemination and progression
Autor: Padmaja Magadala, Joseph J. Buggy, Michelle Francesco, Lucy Jawed, Betty Chang, Stella Chang, Susanne M. Steggerda, Patricia Thiemann
Publikováno v: Cancer Research. 73:923-923
Introduction: Ibrutnib is a potent and selective Btk inhibitor that covalently modifies Cys481 in Btk and inhibits B cell antigen receptor (BCR) signaling. Ibrutinib is currently in a Phase II study in patients with relapsed or refractory mantle cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c43a87969b4911609a1883c1fb90ae3
https://doi.org/10.1158/1538-7445.am2013-923
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