Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Patricia T.W. Cohen"'
Publikováno v:
Biochemical Journal. 478:4025-4025
Ppp5 (protein phosphatase 5) is a serine/threonine protein phosphatase that has been conserved throughout eukaryotic evolution. In mammalian cells, FLAG-tagged Ppp5 and endogenous Ppp5 are found to interact with endogenous Hsp (heat-shock protein) 70
Autor:
Patricia T.W. Cohen, Kathryn Campbell, Martin Voss, David G. Campbell, C. James Hastie, Mark Peggie, Alan R. Prescott, Nastja Saranzewa, Cristina Martin-Granados
Publikováno v:
Cell Cycle
Many pharmaceuticals used to treat cancer target the cell cycle or mitotic spindle dynamics, such as the anti-tumor drug, paclitaxel, which stabilizes microtubules. Here we show that, in cells arrested in mitosis with the spindle toxins, nocodazole,
Autor:
Sandra Rebelo, Patricia T.W. Cohen, Sara C. Domingues, Luís Korrodi-Gregório, Sara L. C. Esteves, Odete A. B. da Cruz e Silva, Ana Paula Vintém, Margarida Fardilha, Edgar F. da Cruz e Silva, Nick Morrice
Publikováno v:
Biochemical Pharmacology. 82:1403-1415
Protein phosphorylation is a critical regulatory mechanism in cellular signalling. To this end, PP1 is a major eukaryotic serine/threonine-specific phosphatase whose cellular functions, in turn, depend on complexes it forms with PP1 interacting prote
Publikováno v:
Journal of Neurochemistry. 118:596-610
J. Neurochem. (2011) 118, 596–610. Abstract Abnormal regulation of brain glycogen metabolism is believed to underlie insulin-induced hypoglycaemia, which may be serious or fatal in diabetic patients on insulin therapy. A key regulator of glycogen l
Autor:
Patricia T.W. Cohen, Martin Voss, Ian R. Kelsall, James Paterson, C. James Hastie, Cristina Martin-Granados, Mark Peggie
Publikováno v:
Cellular Signalling. 23:114-124
Activation of 5'-AMP-activated protein kinase (AMPK) is believed to be the mechanism by which the pharmaceuticals, metformin and phenformin, exert their beneficial effects for treatment of type 2 diabetes. These biguanide drugs elevate 5'-AMP, which
Publikováno v:
Cellular Signalling. 21:1123-1134
Type 2 diabetes is characterised by elevated blood glucose concentrations, which potentially could be normalised by stimulation of hepatic glycogen synthesis. Under glycogenolytic conditions, the interaction of hepatic glycogen-associated protein pho
Publikováno v:
FEBS Journal. 275:4211-4221
Cisplatin (cis-diamminedichloroplatinum) and related chemotherapeutic DNA-crosslinking agents are widely used to treat human cancers. Saccharomyces cerevisiae with separate deletions of the genes encoding the trimeric protein serine/threonine phospha
Publikováno v:
FEBS Letters. 581:4749-4753
The inhibition of hepatic glycogen-associated protein phosphatase-1 (PP1-G(L)) by glycogen phosphorylase a prevents the dephosphorylation and activation of glycogen synthase, suppressing glycogen synthesis when glycogenolysis is activated. Here, we s
Autor:
Barry J. Toole, Patricia T.W. Cohen
Publikováno v:
Cellular Signalling. 19:1044-1055
Adrenaline and insulin are the major hormones regulating glycogen metabolism in skeletal muscle. We have investigated the effects of these hormones on the rate-limiting enzymes of glycogen degradation and synthesis (phosphorylase and glycogen synthas
Autor:
Amanda Philp, Patricia T.W. Cohen, Cristina Vázquez-Martin, C. James Hastie, Michael J. R. Stark
Publikováno v:
FEBS Journal. 273:3322-3334
The anticancer agents cisplatin and oxaliplatin are widely used in the treatment of human neoplasias. A genome-wide screen in Saccharomyces cerevisiae previously identified PPH3 and PSY2 among the top 20 genes conferring resistance to these anticance