Zobrazeno 1 - 10
of 310
pro vyhledávání: '"Patricia S. Goldman"'
Publikováno v:
Neuroscience Letters. 440:59-62
Recent observations suggest that calcyon, a novel single transmembrane protein implicated in schizophrenia and attention-deficit/hyperactivity disorder, regulates clathrin-mediated endocytosis in brain. To explore the role of calcyon in neurotransmis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dfbec8fdf00b7d17d530db4142f73d
https://doi.org/10.1016/j.neulet.2008.05.047
https://doi.org/10.1016/j.neulet.2008.05.047
Publikováno v:
Experimental Brain Research. 164:148-154
The main thalamic afferentation of the prefrontal cortex (PFC) originates in the mediodorsal nucleus (MD). Although it is suggested that this pathway is affected in schizophrenia, there is a lack of functional and structural data regarding its synapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38fdbbd77306acbab465a6bf45f6799
https://doi.org/10.1007/s00221-005-2237-6
https://doi.org/10.1007/s00221-005-2237-6
Publikováno v:
The Journal of Neuroscience. 25:1260-1267
Dopaminergic modulation of glutamate neurotransmission in prefrontal cortex (PFC) microcircuits is commonly perceived as a basis for cognitive operations. Yet it appears that although the control of recurrent excitation between deep-layer prefrontal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd528e6c8af9227771711feac0f0315
https://doi.org/10.1523/jneurosci.3436-04.2005
https://doi.org/10.1523/jneurosci.3436-04.2005
Publikováno v:
Journal of Neurophysiology. 93:614-619
We previously reported that neurons in the mediodorsal thalamic nucleus (MD) are topographically organized and express spatial and nonspatial coding properties similar to those of the prefrontal areas with which they are connected. In the course of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dec1ec7df2cf0c038150ce50471799b
https://doi.org/10.1152/jn.00969.2003
https://doi.org/10.1152/jn.00969.2003
Autor:
Pasko Rakic, Patricia S. Goldman-Rakic, Mary Beth Nebel, Lei Wang, Lynn D. Selemon, John G. Csernansky
Publikováno v:
Biological Psychiatry. 57:83-90
Background Schizophrenia is associated with reductions in thalamic neuronal number and cortical gray matter volume. Exposure of nonhuman primates to x-irradiation in early gestation has previously been shown to decrease thalamic volume and neuronal n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed161fb5b7295ab8c700e21569e2a9d1
https://doi.org/10.1016/j.biopsych.2004.10.014
https://doi.org/10.1016/j.biopsych.2004.10.014
Publikováno v:
The Journal of Physiology. 558:193-211
The common preconception about central nervous system neurones is that thousands of small postsynaptic potentials sum across the entire dendritic tree to generate substantial firing rates, previously observed in in vivo experiments. We present eviden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d9cf907a6270dd7555af815e96e23f
https://doi.org/10.1113/jphysiol.2004.061416
https://doi.org/10.1113/jphysiol.2004.061416
Publikováno v:
Journal of Neuroscience. 24:5292-5300
The explicit yet enigmatic involvement of dopamine in cortical physiology is in part volumetric (beyond the synapse), as is apparently the action of neuroleptics targeting dopamine receptors. The notion that nonsynaptic neuronal membranes would trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4b580109b401f741e58613a0efe72
https://doi.org/10.1523/jneurosci.0195-04.2004
https://doi.org/10.1523/jneurosci.0195-04.2004
Autor:
Yun Wang, Patricia S. Goldman-Rakic
Publikováno v:
Proceedings of the National Academy of Sciences. 101:5093-5098
The efficacy of antipsychotics in the treatment of schizophrenia depends on their ability to block dopamine (DA) D2 receptors. D2 receptor excitatory mediation of glutamatergic receptors has been implicated inin vivostudies. However, D2 receptor enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f219666e7e9ae8b90b8a7c1a22092fc
https://doi.org/10.1073/pnas.0400954101
https://doi.org/10.1073/pnas.0400954101
Publikováno v:
Science. 303:853-856
Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9148d158d14fccb5321126fa9c9d250f
https://doi.org/10.1126/science.1091162
https://doi.org/10.1126/science.1091162
Publikováno v:
Proceedings of the National Academy of Sciences. 101:1368-1373
A conspicuous feature of cortical organization is the wide diversity of inhibitory interneurons; their differential computational functions remain unclear. Here we propose a local cortical circuit in which three major subtypes of interneurons play di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491b7b847e5a4a8cac19ed51026683a9
https://doi.org/10.1073/pnas.0305337101
https://doi.org/10.1073/pnas.0305337101