Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Patricia Rockwell"'
Autor:
Charles H. Wallace, Giovanni Oliveros, Lei Xie, Peter Serrano, Patricia Rockwell, Maria Figueiredo-Pereira
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Alzheimer’s disease (AD) is the major form of dementia prevalent in older adults and with a high incidence in females. Identification of early biomarkers is essential for preventive intervention to delay its progression. Furthermore, due t
Externí odkaz:
https://doaj.org/article/f53658ccfa664502aadb3542cf8eca21
Autor:
Osama Chaudry, Kelechi Ndukwe, Lei Xie, Maria Figueiredo-Pereira, Peter Serrano, Patricia Rockwell
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is most prevalent in females. While estrogen provides neuroprotection in females, sex mediated differences in the development of AD pathology are not fully elucidated
Externí odkaz:
https://doaj.org/article/362429dd53ff4821afb36ff0d130ef5c
Autor:
Jorge A. Avila, Magdalena Kiprowska, Teneka Jean‐Louis, Patricia Rockwell, Maria E. Figueiredo‐Pereira, Peter A. Serrano
Publikováno v:
Brain and Behavior, Vol 10, Iss 1, Pp n/a-n/a (2020)
Abstract Background Inflammation in the brain is mediated by the cyclooxygenase pathway, which leads to the production of prostaglandins. Prostaglandin (PG) D2, the most abundant PG in the brain, increases under pathological conditions and is spontan
Externí odkaz:
https://doaj.org/article/788e8ab9caf340bda5cc17d943f0a8d3
Autor:
Osama Chaudry, Kelechi Ndukwe, Lei Xie, Peter A. Serrano, Maria E. Figueiredo-Pereira, Patricia Rockwell
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and is the sixth leading cause of death in the US. AD is more prevalent in females than males. While estrogen provides neuroprotection in females, sex mediated differences in the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd73733e5167c85fd293d440a5458c0f
https://doi.org/10.1101/2022.03.27.485975
https://doi.org/10.1101/2022.03.27.485975
Autor:
Charles H Wallace, Giovanni Oliveros, Peter A Serrano, Patricia Rockwell, Lei Xie, Maria Figueiredo-Pereira
Publikováno v:
Life Science Alliance. 5:e202201555
We investigated the relevance of the prostaglandin D2 pathway in Alzheimer’s disease, because prostaglandin D2 is a major prostaglandin in the brain. Thus, its contribution to Alzheimer’s disease merits attention, given the known impact of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e506e62bd1daad37818feef1b4febc6
https://doi.org/10.26508/lsa.202201555
https://doi.org/10.26508/lsa.202201555
Autor:
Giovanni Oliveros, Charles H Wallace, Osama Chaudry, Qiao Liu, Yue Qiu, Lei Xie, Patricia Rockwell, Maria E Figueiredo-Pereira, Peter A Serrano
Publikováno v:
Brain
Alzheimer’s disease is a multifactorial disease that exhibits cognitive deficits, neuronal loss, amyloid plaques, neurofibrillary tangles and neuroinflammation in the brain. Hence, a multi-target drug would improve treatment efficacy. We applied a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179ff3230abaaea3fe0f55f531b0eb2a
https://pubmed.ncbi.nlm.nih.gov/35411386
https://pubmed.ncbi.nlm.nih.gov/35411386
Autor:
Teneka Jean-Louis, Patricia Rockwell, Magdalena Kiprowska, Maria E. Figueiredo-Pereira, Jorge A. Avila, Peter A. Serrano
Publikováno v:
Brain and Behavior
Brain and Behavior, Vol 10, Iss 1, Pp n/a-n/a (2020)
Brain and Behavior, Vol 10, Iss 1, Pp n/a-n/a (2020)
Background Inflammation in the brain is mediated by the cyclooxygenase pathway, which leads to the production of prostaglandins. Prostaglandin (PG) D2, the most abundant PG in the brain, increases under pathological conditions and is spontaneously me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f1a84d49d6d7c84abb8da1a7da393a
https://doi.org/10.1002/brb3.1465
https://doi.org/10.1002/brb3.1465
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Mitochondrial impairment and calcium (Ca(++)) dyshomeostasis are associated with Parkinson’s disease (PD). When intracellular ATP levels are lowered, Ca(++)-ATPase pumps are impaired causing cytoplasmic Ca(++) to be elevated and calpain activation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc672135696b4f199bf278d27b3adbb
https://europepmc.org/articles/PMC6502656/
https://europepmc.org/articles/PMC6502656/
Regulation of the amyloid precursor protein (APP) processing by α- and β-secretases is of special interest to Alzheimer's disease (AD), as these proteases prevent or mediate amyloid beta formation, respectively. Neuroinflammation is also implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8ad70f59819f760ab57cc6bfed4d83
https://europepmc.org/articles/PMC5743611/
https://europepmc.org/articles/PMC5743611/
Publikováno v:
Clinical Cancer Research. 21:227-229
Murine mAb 225 was effective against the EGFR tyrosine kinase and inhibited tumor growth in preclinical studies. A phase I trial showed safety, tumor localization, and satisfactory pharmacokinetics. Human:murine chimeric C225 retained biologic activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590d377c3e34cc6859c83e60b71effc9
https://doi.org/10.1158/1078-0432.ccr-14-2491
https://doi.org/10.1158/1078-0432.ccr-14-2491