Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity

Autor: Patricia René, Damien Lanfray, Denis Richard, Michel Bouvier

Publikováno v: JCI Insight, Vol 6, Iss 4 (2021)

MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The present study aimed at determining whether pharmacological chaperones (

Externí odkaz: https://doaj.org/article/06586d55950d47e2a8697e653010b29e

Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene

Autor: Marie-Ange Ventura, Yves de Keyzer, Frédéric Lenne, Xavier Bertagna, Patricia René

Publikováno v: Gene. 241:57-64

In the pituitary, vasopressin triggers ACTH release through a specific receptor subtype, termed V3 or V1b. We cloned the V3 cDNA and showed that its expression was almost exclusive to pituitary corticotrophs and some corticotroph tumors. To study the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f142d0a4d93691e63d22ab2552fbf5
https://doi.org/10.1016/s0378-1119(99)00468-0

Contents, Vol. 47, 1997

Autor: P. Chanson, X. Jeunemaitre, M. Talbot, D. Simpson, Emmanuel Gautherot, Annick Martin, Maria Luisa Brandi, Jp. Aubert, Catharina Larsson, F. Mantero, Cx. Zhang, David Wynford-Thomas, Claude Jaffiol, M. Boggild, Simona Mantovani, A.M. Masini, Eric Clauser, A. Angeli, Véronique Alvaro, Cristina Missale, G. Gunz, B. Fournes, A. Enjalbert, Olov Nilsson, I. Morange-Ramos, Charis Eng, B. Conte-Devolx, A. Courseaux, Eric Rouvier, A. Murat, Lars-Ove Farnebo, Alessandra Finardi, Filip Farnebo, G. Cadiot, P. Niccoli, B. Allolio, C. Beldjord, Massimo Giovanelli, Colette Auzan, P. Jaquet, P. Gaudray, Corinne Prévostel, Chiara Fiorentini, A. Ali, M. Giovagnetti, Pascal Meyer, R. Monier, B. Maes, Marco Losa, M. Terzolo, V. Aubert, Xavier Bertagna, Sandra Sigala, J.F. Hewy, W. Farrell, G. Arnaldi, M. Klein, A. Calender, J. Leclère, Jérôme Bertherat, Frederic Lenne, G. Osella, Patricia René, J. Bicknell, Andrea Lania, N. Porchet, Pf. Plouin, C. Gicquel, M.C. Béné, A. Barlier, Lois M. Mulligan, A. Boneu, L. Caccavelli, B. Caillou, Anna Spada, P. Rochefort, G. Opocher, G. Faure, Jacques Barbel, S. Giraud, Deborah J. Marsh, F. Michiels, Johannes Järhult, P. Rodien, Jacob Lagercrantz, Bin Tean Teh, J. Feunteun, G. Weryha, Dominique Joubert, M. Reincke, I. Schuffenecker, J.B. Corcuff, L. Mercken, Kerstin Sandelin, C. Dumont, M. Schlumberger, Y. Le Bouc, E. Modigliani, Yves de Keyzer, V. Pascal-Vigneron, Emilia Ballaré, Günther Weber, A.S. Bates, R.N. Clayton, I. Pellegrini-Bouiller, PierFranco Spano, N. Barbot, Gm. Lenoir

Publikováno v: Hormone Research. 47:I-IV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d297928ac32ca3c3c7aadb06ed80a60c
https://doi.org/10.1159/000185453

Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity

Autor: Patricia René, Gary Lee, Irina D. Pogozheva, Michel Bouvier, Henry I. Mosberg, Christian Le Gouill, Kenneth J. Valenzano, I. Sadaf Farooqi

Publikováno v: The Journal of pharmacology and experimental therapeutics. 335(3)

Heterozygous null mutations in the melanocortin-4 receptor (MC4R) cause early-onset obesity in humans, indicating that metabolic homeostasis is sensitive to quantitative variation in MC4R function. Most of the obesity-causing MC4R mutations functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0496fc098d585772cb1fa647a3109e7f
https://pubmed.ncbi.nlm.nih.gov/20826565

Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance

Autor: Jan Felix, Claire Siebert, Julia Novion Ducassou, Jérôme Nigou, Pierre Simon Garcia, Angélique Fraudeau, Karine Huard, Caroline Mas, Céline Brochier-Armanet, Yohann Couté, Irina Gutsche, Patricia Renesto

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)

Abstract Francisella tularensis is one of the most virulent pathogenic bacteria causing the acute human respiratory disease tularemia. While the mechanisms underlying F. tularensis pathogenesis are largely unknown, previous studies have shown that a

Externí odkaz: https://doaj.org/article/bf9733d66c7542f68a83f9b9f0353881