Výsledky vyhledávání - "Patricia Redecha"

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

Autor: David R. Mcllwain, Carl P. Blobel, Xiaoping Qing, Patricia Redecha, Jane E. Salmon, Tak W. Mak, Priya D. Issuree, Gregory Farber, Michael P. Madaio, Laura T. Donlin, Yurii Chinenov, Joris J. T. H. Roelofs

Publikováno v: Journal of clinical investigation, 128(4), 1397-1412. The American Society for Clinical Investigation

Lupus nephritis (LN) often results in progressive renal dysfunction. The inactive rhomboid 2 (iRhom2) is a newly identified key regulator of A disintegrin and metalloprotease 17 (ADAM17), whose substrates, such as TNF-α and heparin-binding EGF (HB-E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d07d7b6773cd8481c395a9f1c868d62
https://doi.org/10.1172/jci97650

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iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice

Autor: Arthur Mortha, Carl P. Blobel, Tak W. Mak, Thorsten Maretzky, Xiaoping Qing, Jane E. Salmon, Lindsay D. Rogers, Priya D. Issuree, Yonit Lavin, Miriam Merad, David R. McIlwain, Christopher M. Overall, Patricia Redecha

Publikováno v: European Journal of Immunology. 46:2737-2748

The colony stimulating factor 1 receptor (CSF1R) functions as the major receptor for macrophage colony stimulating factor (CSF1) with crucial roles in regulating myelopoeisis. CSF1R can be proteolytically released from the cell surface by A disintegr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de6860a3c9370e981382a1fd6eb48aa
https://doi.org/10.1002/eji.201646482

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ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice

Autor: Milena Vukelic, Patricia Redecha, Anastasia Sacharidou, Victoria Ulrich, Philip W. Shaul, Shari E. Gelber, Jane E. Salmon, Rolf T. Urbanus, David R. C. Natale, Philip G. de Groot, Chieko Mineo, Joachim Herz, Anirudha Harihara, Vikki M. Abrahams

Publikováno v: Arthritis & Rheumatology. 68:730-739

OBJECTIVE: Pregnancies in women with the antiphospholipid syndrome (APS) are frequently complicated by fetal loss and intrauterine growth restriction (IUGR). How circulating antiphospholipid antibodies (aPL) cause pregnancy complications in APS is po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d1342c0a1e51421ee77cc710385360c
https://doi.org/10.1002/art.39453

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Interferon-α and Angiogenic Dysregulation in Pregnant Lupus Patients Who Develop Preeclampsia

Autor: Luz P. Blanco, Mimi Y. Kim, Danieli Andrade, Mary K. Crow, Jane E. Salmon, Vikki M. Abrahams, Melissa J. Mulla, S. Ananth Karumanchi, Patricia Redecha, Angela M. Alvarez, Kyriakos A. Kirou, Mariana J. Kaplan, Gloria C. Koo

Publikováno v: Arthritis & Rheumatology. 67:977-987

Systemic lupus erythematosus (SLE), the prototypic systemic autoimmune disease, predominantly afflicts women and presents during reproductive years. Pregnancy in patients with SLE is associated with increased risk for maternal and fetal morbidity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f830c9a34aa1efb1c57f98ecd9862d7e
https://doi.org/10.1002/art.39029

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Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2−/−IL-2Rγ−/− mice: A promising model for studying human disease

Autor: Xiaoping Qing, Jane E. Salmon, Milena Vukelic, Gloria C. Koo, Patricia Redecha, Giorgio Perino, Danieli Andrade

Publikováno v: Arthritis & Rheumatism. 63:2764-2773

Purpose To construct a humanized SLE mouse that resembles the human disease to define pathophysiology and targeted for treatments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9539c50bb4d74c4f089f85fa8dcab42
https://doi.org/10.1002/art.30424

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Targeted inhibition of complement activation prevents features of preeclampsia in mice

Autor: Patricia Redecha, Vivette D. D'Agati, Jane E. Salmon, Xiaoping Qing, Robin L. Davisson, Melissa A. Burmeister, Stephen Tomlinson

Publikováno v: Kidney International. 79(3):331-339

Preeclampsia is a major cause of maternal and neonatal morbidity and mortality. In mouse models, complement activation in the placenta is associated with abnormal placental development and miscarriage, and inhibiting complement prevents fetal injury.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd62564f0481a5f3f4d6affe1c01566

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Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies

Autor: Marc Monestier, Patricia Redecha, Surya V. Seshan, Claus Werner Franzke, Guillermina Girardi, Nigel Mackman

Publikováno v: Blood. 114:1675-1683

Using different mouse monoclonal and human antiphospholipid (aPL) antibodies, we developed a new animal model of renal injury that shares many features with thrombotic microangiopathy (TMA). We found that more than 1 mechanism/signaling pathway is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f3e3db9287ef2356c7c8be79978b02
https://doi.org/10.1182/blood-2009-01-199117

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Infliximab treatment shifts the balance between stimulatory and inhibitory Fcγ receptor type II isoforms on neutrophils in patients with rheumatoid arthritis

Autor: Luminita Pricop, Ani Aydin, Patricia Redecha, Melanie J. Harrison, Jane E. Salmon, Kristina Belostocki, Linda Leff

Publikováno v: Arthritis & Rheumatism. 58:384-388

Human neutrophils express both activating and inhibitory Fcgamma receptors (FcgammaR), and their relative expression determines the inflammatory response to immune complexes. Tumor necrosis factor alpha (TNFalpha) up-regulates the expression of stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5797841579dcb8efac509fd37bdc5898
https://doi.org/10.1002/art.23200

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Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody–induced fetal injury

Autor: Nigel Mackman, Rachel E. Tilley, Patricia Redecha, Guillermina Girardi, Daniel Kirchhofer, Michael Tencati, Jane E. Salmon

Publikováno v: Blood. 110:2423-2431

Fetal loss in patients with antiphospholipid (aPL) antibodies has been ascribed to thrombosis of placental vessels. However, we have shown that inflammation, specifically activation of complement with generation of the anaphylotoxin C5a, is an essent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead43a7ff83ae611f6fc50caf064fed5
https://doi.org/10.1182/blood-2007-01-070631

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Interferon-α and angiogenic dysregulation in pregnant lupus patients destined for preeclampsia

Autor: Danieli, Andrade, Mimi, Kim, Luz P, Blanco, S Ananth, Karumanchi, Gloria C, Koo, Patricia, Redecha, Kyriakos, Kirou, Angela M, Alvarez, Melissa J, Mulla, Mary K, Crow, Vikki M, Abrahams, Mariana J, Kaplan, Jane E, Salmon

Publikováno v: Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia

Objective. To investigate whether an elevatedinterferon-␣(IFN␣) level early in pregnancy is associ-ated with poor pregnancy outcomes and to examine the relationship of an elevated IFN␣level to angiogenicimbalance.Methods. Women were enrolled in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::644e02a3500e0c83d038a713cc877288

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