Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Patricia Peking"'
Autor:
Patricia Peking, Ulrich Koller, Stefan Hainzl, Sophie Kitzmueller, Thomas Kocher, Elisabeth Mayr, Alexander Nyström, Thomas Lener, Julia Reichelt, Johann W Bauer, Eva M Murauer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
RNA trans-splicing represents an auspicious option for the correction of genetic mutations at RNA level. Mutations within COL7A1 causing strong reduction or absence of type VII collagen are associated with the severe skin blistering disease dystrophi
Externí odkaz:
https://doaj.org/article/7415625472d94827a1e3e8761f7d7ce9
Autor:
Katharina Muigg, Katharina Schallmoser, Cornelia Scharler, Martin Wolf, Anna Hoog, Patricia Peking, Harald Stachelscheid, Elisabeth Russe, Rodolphe Poupardin, Linda Krisch, Achim Schneeberger, Dirk Strunk, Balazs Vari
Stem/progenitor cells can self-organize into organoids modelling tissue function and regeneration. Here we demonstrate that human platelet-derived factors can orchestrate 3D self-assembly of clonally expanded adult skin fibroblasts, keratinocytes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17de5567d1080ce7f42c443972468bf2
https://doi.org/10.1101/2020.09.10.292409
https://doi.org/10.1101/2020.09.10.292409
Autor:
Martin Wolf, Laurence Daheron, Hans-Dieter Volk, Dirk Strunk, Patricia Peking, Katharina Schallmoser, Gabriele Brachtl, Harald Stachelscheid, K. Juerchott, Cornelia Scharler, Rodolphe Poupardin
Stromal cells contribute to organ integrity as fibroblasts and to vascular stability as pericytes, in addition to their enigmatic niche function in many tissues. Their inherent immunomodulatory capacity attracted particular attention, initiating nume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::559122fea937696d77aedfdb7cb9b5d2
https://doi.org/10.1101/2020.07.07.192385
https://doi.org/10.1101/2020.07.07.192385
Autor:
Stefan Hainzl, Thomas Lettner, Patricia Peking, Ulrich Koller, F.J. Poetschke, Wolfgang Muss, Sophie Kitzmueller, Jenny Breitenbach, Verena Wally, Julia Reichelt, Thomas Kocher, Michael Ablinger, Johann W. Bauer
Publikováno v:
The British Journal of Dermatology
Summary Background Generalized severe epidermolysis bullosa simplex (EBS‐gen sev) is a genetic blistering skin disease in which autosomal dominant mutations in either the keratin KRT5 or KRT14 genes lead to impaired function of the intermediate fil
Publikováno v:
Advanced Drug Delivery Reviews. 129:330-343
Chronic wounding as a result of recurrent skin blistering in the painful genetic skin disease epidermolysis bullosa, may lead to life-threatening infections, increased risk of tumor formation, and other serious medical complications. Therefore, epide
Autor:
Ulrich Koller, Tobias Maetzig, Thomas Kocher, Axel Schambach, Marta García, Susanne A. Wolf, Johann W. Bauer, Eva M. Murauer, Patricia Peking, Gabriele Brachtl, Fernando Larcher, Blanca Duarte, Julia Reichelt, Rodolfo Murillas, Michael Rothe
Publikováno v:
Nucleic Acids Research
Functional impairment or complete loss of type VII collagen, caused by mutations within COL7A1, lead to the severe recessive form of the skin blistering disease dystrophic epidermolysis bullosa (RDEB). Here, we successfully demonstrate RNA trans-spli
Autor:
Alfred Klausegger, Julia Reichelt, Josefina Piñón Hofbauer, Nina Lackner, Christina Guttmann-Gruber, Patricia Peking, Ulrich Koller, Thomas Kocher, Neil Rajan, Oliver Patrick March, Thomas Lettner, Stefan Hainzl, Anette Bygum, Michael Ablinger
Publikováno v:
March, O P, Lettner, T, Klausegger, A, Ablinger, M, Kocher, T, Hainzl, S, Peking, P, Lackner, N, Rajan, N, Hofbauer, J P, Guttmann-Gruber, C, Bygum, A, Koller, U & Reichelt, J 2019, ' Gene Editing–Mediated Disruption of Epidermolytic Ichthyosis–Associated KRT10 Alleles Restores Filament Stability in Keratinocytes ', Journal of Investigative Dermatology, vol. 139, no. 8, pp. 1699-1710.e6 . https://doi.org/10.1016/j.jid.2019.03.1146
Epidermolytic ichthyosis is a skin fragility disorder caused by dominant-negative mutations in KRT1 or KRT10. No definitive restorative therapies exist that target these genetic faults. Gene editing can be used to efficiently introduce frameshift mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7415cc314ce712ffd3fe9e37f5402b
https://findresearcher.sdu.dk:8443/ws/files/152548397/Gene_Editing_Mediated_Disruption_of_Epidermolytic_Ichthyosis_Associated_KRT10_Alleles_Restores_Filament_Stability_in_Keratinocytes.pdf
https://findresearcher.sdu.dk:8443/ws/files/152548397/Gene_Editing_Mediated_Disruption_of_Epidermolytic_Ichthyosis_Associated_KRT10_Alleles_Restores_Filament_Stability_in_Keratinocytes.pdf
Autor:
Annamarie Hamel, Susanne Kimeswenger, Manfred Kunz, Martin Stock, Katharina Böhm, Svea Hüning, Clemens Hüttner, Ralf Ludwig, Patricia Peking, Ugur Uslu, Martin Glatz, Saira Munir, Theodora Kanaki, Manuel P. Pereira, Carolin Schlumprecht, Adriana Rendon, Fabian Gendrisch, Saeedeh Ghorbanalipoor, Jessica Tillmanns, Kristin Plesser, Anna Smorodchenko, Stephan Grabbe, Irina Iwanova, Kamran Ghoreschi, Meltem Barlin, Sukalp Muzumdar, Stefanie Häberle, Maximilian Rentschler, Karin Scharffetter-Kochanek, Amir S. Yazdi, Nadine Lohmann, Karin Loser
Publikováno v:
Experimental Dermatology. 26:292-294
Autor:
Eva M. Murauer, Olivier Bornert, Anna M.G. Pasmooij, Peter C. van den Akker, Alexander Nyström, Annemieke Aartsma-Rus, Patricia Peking, Jeroen Bremer, Ulrich Koller
Publikováno v:
Experimental Dermatology, 26(1), 3-10
Genetic disorders affecting the skin, genodermatoses, constitute a large and heterogeneous group of diseases, for which treatment is generally limited to management of symptoms. RNA-based therapies are emerging as a powerful tool to treat genodermato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc306aa8c21e93b671e4cff677a793be
http://hdl.handle.net/1887/94903
http://hdl.handle.net/1887/94903
Autor:
Patricia Peking, Stefan Hainzl
Publikováno v:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 16:527-528