Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Patricia Ortega-Sáenz"'
Autor:
Elizabeth P. Lewis, Fatimah Al Khazal, Brandon Wilbanks, Naomi M. Gades, Patricia Ortega‐Sáenz, José López‐Barneo, Igor Adameyko, L. James Maher III
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 327-336 (2024)
Abstract In humans, loss of heterozygosity for defective alleles of any of the four subunits of mitochondrial tricarboxylic acid cycle enzyme succinate dehydrogenase (SDH, also Complex II of the electron transport chain) can lead to paraganglioma tum
Externí odkaz:
https://doaj.org/article/29cd999d7e6e4937bf53906a8080350f
Autor:
Blanca Jiménez-Gómez, Patricia Ortega-Sáenz, Lin Gao, Patricia González-Rodríguez, Paula García-Flores, Navdeep Chandel, José López-Barneo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Activation of breathing during hypoxia is abolished in mice lacking mitochondrial complex I in carotid body chemoreceptors, however the specific contribution of mitochondrial complex I to this process is unclear. Here, the authors show that recovery
Externí odkaz:
https://doaj.org/article/c9432bcd2efa48e48202eb9116a93bde
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Lactate levels in blood change during hypoxia or exercise, however whether this variable is sensed to evoke adaptive responses is unknown. Here the authors show that oxygen-sensing carotid body cells stimulated by hypoxia are also activated by lactat
Externí odkaz:
https://doaj.org/article/337a29a5be2d461eb8785176a46319bd
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100535- (2021)
Summary: Reactive oxygen species (ROS) are important signaling molecules for physiologic processes such as acute response to hypoxia. However, reliable real-time ROS measurement in cells has been a long-standing methodological challenge. Here, we pre
Externí odkaz:
https://doaj.org/article/19197bd2ef5049bc970974d2b14c4e1f
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical and chemical parameters in the blood. These cells are also essential for O2 homeostasis. Glomus cells are prototypical peripheral
Externí odkaz:
https://doaj.org/article/9bad6bb655ee4783b192266ca7f2f1d8
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 908-915 (2017)
Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposu
Externí odkaz:
https://doaj.org/article/9d0e12eaa42241e7b7f6fe6a98cc97f0
Autor:
David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, José López-Barneo, Randall Johnson
Publikováno v:
eLife, Vol 7 (2018)
Externí odkaz:
https://doaj.org/article/5584b821c06940a8a4514812a2f7c128
Autor:
David Macias, Andrew S Cowburn, Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, José López-Barneo, Randall S Johnson
Publikováno v:
eLife, Vol 7 (2018)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing forms of adaptive response
Externí odkaz:
https://doaj.org/article/704e71e0017f4cd797a4b3f2c5fa55a5
Autor:
Daniel Cabello-Rivera, Patricia Ortega-Sáenz, Lin Gao, Ana M. Muñoz-Cabello, Victoria Bonilla-Henao, Paul T. Schumacker, José López-Barneo
Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with restricted exchange of gases in the lung. The main acute O2-sensing organ is the carotid body (CB), which contains neurosecretory ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adec3a9f23e8cfce2780630adf412507
http://hdl.handle.net/10261/307112
http://hdl.handle.net/10261/307112
Significance: Acute responses to hypoxia are essential for the survival of mammals. The carotid body (CB), the main arterial chemoreceptor, contains glomus cells with oxygen (O2)-sensitive K+ channels, which are inhibited during hypoxia to trigger ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9dc2742e1a225b4ce25f6053ab4e43
https://api.elsevier.com/content/abstract/scopus_id/85135420849
https://api.elsevier.com/content/abstract/scopus_id/85135420849