Promiscuous, Multi-Target Lupane-Type Triterpenoids Inhibits Wild Type and Drug Resistant HIV-1 Replication Through the Interference With Several Targets

Autor: Luis M. Bedoya, Manuela Beltrán, Javier García-Pérez, Patricia Obregón-Calderón, Oliver Callies, Ignacio A. Jímenez, Isabel L. Bazzocchi, José Alcamí

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Current research on antiretroviral therapy is mainly focused in the development of new formulations or combinations of drugs belonging to already known targets. However, HIV-1 infection is not cured by current therapy and thus, new approaches are nee

Externí odkaz: https://doaj.org/article/6d2e36e7b57e4efd8a160bf22fc16676

Characterization of a novel interaction between Bcl-2 members Diva and Harakiri.

Autor: Lorenzo Sborgi, Susana Barrera-Vilarmau, Patricia Obregón, Eva de Alba

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15575 (2010)

Interactions within proteins of the Bcl-2 family are key in the regulation of apoptosis. The death-inducing members control apoptotic mechanisms partly by antagonizing the prosurvival proteins through heterodimer formation. Structural and biophysical

Externí odkaz: https://doaj.org/article/56fe58f5351d400ab1bf24f5033c3b40

Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina

Autor: Luis M. Bedoya, Isabel L. Bazzocchi, Alex A. Osorio, Patricia Obregón Calderón, Alejandro Munoz, Ignacio A. Jiménez, José Alcamí, Manuela Beltrán, Oliver Callies

Publikováno v: Journal of Natural Products. 78:1045-1055

As a part of our investigation into new anti-HIV agents, we report herein the isolation, structure elucidation, and biological activity of six new (1-6) and 20 known (7-26) pentacyclic lupane-type triterpenoids from the stem of Cassine xylocarpa and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8023f6d6fb4924198f04b5119149e9
https://doi.org/10.1021/np501025r

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Autor: Raquel Martín, Carmen Castresana, Patricia Obregón, A.G. Sanz

Publikováno v: Plant Molecular Biology. 46:67-77

The correlation between activation of defence-related gene expression and plant senescence was investigated by evaluating the presence of specific transcripts in various leaves of tobacco senescing plants. Expression of most genes examined was found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f51a04d75ca6b666744c7e6bf4e19d0
https://doi.org/10.1023/a:1010640811983

Differential in vitro DNA binding activity to a promoter element of the gn1 beta-1,3-glucanase gene in hypersensitively reacting tobacco plants

Autor: Elena Alonso, Patricia Obregón, Marc Van Montagu, Godelieve Gheysen, Carmen Castresana, Dirk Inzé, Fernanda de Carvalho Niebel

Publikováno v: Plant Journal
Plant Journal, Wiley, 1995, 7 (2), pp.309-320. ⟨10.1046/j.1365-313x.1995.7020309.x⟩
Plant Journal, Wiley, 1995, 7 (2), pp.309-320

International audience; In a hypersensitive reaction to pathogen infection, expression of the beta-1,3-glucanase gn1 gene is induced in cells surrounding the necrotic lesions. The 5'-flanking sequence of gn1 was examined to investigate the molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01613879369f659aa077aed3ceb4bbc0
https://pubmed.ncbi.nlm.nih.gov/7704049