Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Patricia Mendoza-Garcia"'
Autor:
Sanjay Kumar Sukumar, Vimala Antonydhason, Linnea Molander, Jawdat Sandakly, Malak Kleit, Ganesh Umapathy, Patricia Mendoza-Garcia, Tafheem Masudi, Andreas Schlosser, Dick R Nässel, Christian Wegener, Margret Shirinian, Ruth H Palmer
Publikováno v:
eLife, Vol 12 (2024)
Numerous roles for the Alk receptor tyrosine kinase have been described in Drosophila, including functions in the central nervous system (CNS), however the molecular details are poorly understood. To gain mechanistic insight, we employed Targeted Dam
Externí odkaz:
https://doaj.org/article/dfd88ed48fda4c0e92b123d709909f88
Autor:
Martin Peterka, Nina Akrap, Songyuan Li, Sandra Wimberger, Pei-Pei Hsieh, Dmitrii Degtev, Burcu Bestas, Jack Barr, Stijn van de Plassche, Patricia Mendoza-Garcia, Saša Šviković, Grzegorz Sienski, Mike Firth, Marcello Maresca
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Prime editing is a next-generation approach for precision genome engineering. Here the authors design a nuclease-based prime editor that leverages DNA repair pathways for targeted genomic insertions.
Externí odkaz:
https://doaj.org/article/25fe27eaf624442f9610f0f8e6483f5c
Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival
Autor:
Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Mats Bemark, Patricia Mendoza-Garcia, Ruth H. Palmer
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/C
Externí odkaz:
https://doaj.org/article/07bf718e76ba44b88c1bdc5f2a42c7cc
Autor:
Sandra Wimberger, Burcu Bestas, Pei-Pei Hsieh, Mike Firth, Marcello Maresca, Grzegorz Sienski, Stijn van de Plassche, Songyuan Li, Saša Šviković, Dmitrii Degtev, Martin Peterka, Patricia Mendoza-Garcia, Nina Akrap, Jack Barr
Publikováno v:
Nature communications. 13(1)
Prime editing recently emerged as a next-generation approach for precise genome editing. Here we exploit DNA double-strand break (DSB) repair to develop two novel strategies that install precise genomic insertions using an SpCas9 nuclease-based prime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acc9ccbe14cde5ee287111806a787de
https://pubmed.ncbi.nlm.nih.gov/35332138
https://pubmed.ncbi.nlm.nih.gov/35332138
Autor:
Mats Bemark, Patricia Mendoza-Garcia, Georg Wolfstetter, Ruth H. Palmer, Molander L, Jan Larsson, Badrul Arefin, Swaraj Basu, Erik Larsson, Anthonydhason, SK Sukumar, Henrik Lindehell
Development of the midgut visceral muscle ofDrosophilacrucially depends on Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) signalling, which is needed to specify founder cells (FCs) in the circular visceral mesoderm (VM). While activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8ba8668c8b7b9c929cfe84c4d36bcb3
https://doi.org/10.1101/2021.01.25.428051
https://doi.org/10.1101/2021.01.25.428051
Autor:
Tafheem A Masudi, Wei-Yun Lai, Barbara Witek, Jikui Guan, Arne Claeys, Jimmy Van den Eynden, Marcus Borenäs, Abeer El Wakil, Jan Koster, Dan E. Lind, Jennie Gaarder, Bengt Hallberg, Mathias Johansson, Patricia Mendoza-Garcia, Badrul Arefin, Ganesh Umapathy, Tzu-Po Chuang, Susanne Fransson, Ruth H. Palmer
Publikováno v:
EMBO JOURNAL
The EMBO Journal
EMBO journal, 40(3):e105784. Wiley-Blackwell
The EMBO Journal
EMBO journal, 40(3):e105784. Wiley-Blackwell
High‐risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to cancer. One indicator of high‐risk NB is amplification of the neural MYC (MYCN) oncogene, which is currently therapeutically intractable. Identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c899515cacb2806e0ab2b680fe6846df
https://biblio.ugent.be/publication/8686831
https://biblio.ugent.be/publication/8686831
Autor:
Patricia Mendoza-Garcia, Swaraj Basu, Sanjay Kumar Sukumar, Badrul Arefin, Georg Wolfstetter, Vimala Anthonydhason, Linnea Molander, Ezgi Uçkun, Henrik Lindehell, Cristina Lebrero-Fernandez, Jan Larsson, Erik Larsson, Mats Bemark, Ruth H. Palmer
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Development of the Drosophila visceral muscle depends on Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) signaling, which specifies founder cells (FCs) in the circular visceral mesoderm (VM). Although Alk activation by its ligand Jell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d8ab2f7c8b17155f33cde4472c830f
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190470
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190470
Autor:
Kathrin Pfeifer, Ruth H. Palmer, Georg Wolfstetter, Sa Chen, Anne Uv, Patricia Mendoza-Garcia, Tafheem A Masudi, Mattias Backman, Ezgi Uçkun, SK Sukumar, Gaurav K. Varshney, Hannah Sonnenberg
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase of the insulin receptor super-family that functions as oncogenic driver in a range of human cancers such as neuroblastoma. In order to investigate mechanisms underlying Alk oncogenic sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2ebf4b690a88dbfacf6a33b447995f
https://doi.org/10.1038/s41598-020-70890-6
https://doi.org/10.1038/s41598-020-70890-6
Autor:
Wasi Alam, Marcus Borenäs, Ganesh Umapathy, Bengt Hallberg, Patricia Mendoza-Garcia, Joanna Szydzik, Kathrin Pfeifer, Ruth H. Palmer, Joachim T. Siaw, Diana Cervantes-Madrid, Jikui Guan, Dan E. Lind
Publikováno v:
Cancer Research. 80:A36-A36
Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK), has been identified as a fusion partner in a diverse variety of translocation events resulting in oncogenic signaling in many different cancer types. In tumors w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96c72dd1caa0491bcb1515c1a57792c
https://doi.org/10.1158/1538-7445.pedca19-a36
https://doi.org/10.1158/1538-7445.pedca19-a36
Autor:
Kathrin Pfeifer, Ruth H. Palmer, Ajeet Pratap Singh, Patricia Mendoza Garcia, Fabrizio C. Serluca, Andrey Fadeev, Uwe Irion, Christiane Nüsslein-Volhard, Stephanie Wiessner, Jikui Guan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance Neuroblastoma is a pediatric tumor arising from the neural crest. Dysregulation of the receptor tyrosine kinase ALK has been linked to neuroblastoma, making it important to understand its function in native conditions. In zebrafish, a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa1a8645502f72c5d604df8c3cd3e98