Výsledky vyhledávání - "Patricia M.G.E. Brown"

Alternative Splicing of the Flip/Flop Cassette and TARP Auxiliary Subunits Engage in a Privileged Relationship That Fine-Tunes AMPA Receptor Gating

Autor: Amanda M. Perozzo, Patricia M.G.E. Brown, Derek Bowie

Publikováno v: The Journal of Neuroscience. 43:2837-2849

Alternative splicing of AMPA-type glutamate receptors (AMPARs) and allosteric modulation by auxiliary subunits, such as transmembrane AMPAR regulatory proteins (TARPs), are two important mechanisms that regulate the time course of glutamatergic neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04bf2b68cdd0a4b9a36daa824e5cd794
https://doi.org/10.1523/jneurosci.2293-22.2023

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Author response: Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

Autor: Patricia M.G.E. Brown, Joel R. Meyerson, Nandish Khanra, Amanda M Perozzo, Derek Bowie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77011b6ed077b054e477754502a5366f
https://doi.org/10.7554/elife.66097.sa2

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α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid and Kainate Receptors

Autor: Derek Bowie, G. Brent Dawe, Patricia M.G.E. Brown

Publikováno v: The Oxford Handbook of Neuronal Ion Channels ISBN: 9780190669164

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate-type glutamate receptors (AMPARs and KARs) are dynamic ion channel proteins that govern neuronal excitation and signal transduction in the mammalian brain. The four AMPAR and fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc713b851f637419794f59f0ac50faa2
https://doi.org/10.1093/oxfordhb/9780190669164.013.8

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Structural and Functional Properties of Ionotropic and Metabotropic Glutamate Receptors

Autor: Derek Bowie, G. Brent Dawe, Patricia M.G.E. Brown, Anne Feltz

Publikováno v: Physiology of Neurons ISBN: 9780429292972
Physiology of Neurons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f41af8e26eea3e778700462afcc01ab
https://doi.org/10.1201/9780429292972-9

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Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation

Autor: Patricia M.G.E. Brown, Derek Bowie, Hugo McGuire

Publikováno v: The Journal of General Physiology

Polyamine block of AMPA-type ionotropic glutamate receptors is attenuated by auxiliary proteins stargazin and cornichon-3. Brown et al. show that relief from block is due to enhanced blocker permeation and present a modified model of permeant channel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a017d2f39bed35a553eaf22121c5c90b
http://europepmc.org/articles/PMC5749116

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Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

Autor: Liwei Han, Stinne W. Hansen, Karla Frydenvang, Lennart Bunch, Karina Koch, Claudia G. Delgar, Charlotte Møller, Tri H. V. Huynh, Darryl S. Pickering, Niels Krogsgaard-Larsen, Birgitte Nielsen, Patricia M.G.E. Brown, Jette S. Kastrup, Derek Bowie

Publikováno v: Journal of Medicinal Chemistry. 60:441-457

Ionotropic glutamate receptor antagonists are valuable tool compounds for studies of neurological pathways in the central nervous system. On the basis of rational ligand design, a new class of selective antagonists, represented by (2S,4R)-4-(2-carbox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf41acb2aaafe10e76c5b656ba2b0bfb
https://doi.org/10.1021/acs.jmedchem.6b01516

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6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells

Autor: Patricia M.G.E. Brown, Loïs S. Miraucourt, Michael V. Accardi, Beverley A. Orser, Derek Bowie

Publikováno v: Journal of Neuroscience. 35:9676-9688

Activity-dependent strengthening of central synapses is a key factor driving neuronal circuit behavior in the vertebrate CNS. At fast inhibitory synapses, strengthening is thought to occur by increasing the number of GABA(A) receptors (GABARs) of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee25a2b639d4d1d7195dbb6237fc63d
https://doi.org/10.1523/jneurosci.0513-15.2015

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Functional and Structural Characterization of the GluK2/GluK5 Heterotetramer Gating Mechanism

Autor: Teresa Paramo, Maria Musgaard, Philip C. Biggin, Derek Bowie, Mark R. P. Aurousseau, Patricia M.G.E. Brown

Publikováno v: Biophysical Journal. 110(3)

Ionotropic glutamate receptors (iGluRs) mediate most of the excitatory synaptic neurotransmission, controlling synaptic strength and plasticity, aspects which are thought to underlay learning and memory. These ligand-gated ion channels are classified

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