Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Patricia M. Whitaker"'
Autor:
Efrain C. Azmitia, M. F. Alzoobaee, Z. T. Saccomano, Patricia M. Whitaker-Azmitia, Maura Boldrini
Publikováno v:
Journal of Autism and Developmental Disorders. 46:1307-1318
In the current work, we conducted an immunocytochemical search for markers of ongoing neurogenesis (e.g. nestin) in auditory cortex from postmortem sections of autism spectrum disorder (ASD) and age-matched control donors. We found nestin labeling in
Role of the Neurotrophic Properties of Serotonin in the Delay of Brain Maturation Induced by Cocaine
Autor:
Patricia M. Whitaker-Azmitia
Publikováno v:
Annals of the New York Academy of Sciences. 846(1)
Publikováno v:
Medical Hypotheses. 82:313-318
Studies show increased autism risk among children born to mothers experiencing obstetrical complications. Although this is usually interpreted as suggesting that the obstetrical complications could be causing autism, it is possible that a single fact
Publikováno v:
Brain, Behavior, and Immunity
Microglia can shift into different complex morphologies depending on the microenvironment of the central nervous system (CNS). The distinct morphologies correlate with specific functions and can indicate the pathophysiological state of the CNS. Previ
Publikováno v:
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 294:1663-1670
The phenotypic expression of autism spectrum disorders varies widely in severity and characteristics and it is, therefore, likely that a number of etiological factors are involved. However, one finding which has been found consistently is that there
Publikováno v:
Neuropharmacology. 60:1347-1354
Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhi
Publikováno v:
Cardiovascular Psychiatry and Neurology
S100B promotes development and maturation in the mammalian brain. However, prolonged or extensive exposure can lead to neurodegeneration. Two important functions of S100B in this regard, are its role in the development and plasticity of the serotoner
Publikováno v:
Brain Research. 1189:203-214
Prior research has reliably found high blood (hyperserotonemia) - but low brain - serotonin levels in autistic individuals. At early stages of development, high levels of serotonin in the blood may enter the brain of a developing fetus, causing a los
Autor:
R. Kinyamu, Eldon E. Geisert, Mathew Blurton-Jones, Charles E. Ribak, Kwan L. Ng, Lee A. Shapiro, Qun-Yong Zhou, Patricia M. Whitaker-Azmitia
Publikováno v:
Brain Structure and Function. 212:133-148
Newly generated neurons are continuously added to the olfactory epithelium and olfactory bulbs of adult mammals. Studies also report newly generated neurons in the piriform cortex, the primary cortical projection site of the olfactory bulbs. The curr
Publikováno v:
Brain Research. 1019:39-46
S100B is a calcium-binding protein found within astroglial cells. When released, S100B has extracellular neurotrophic effects involving the neuronal cytoskeleton. The gene for S100B is located on chromosome 21 and levels of the protein are elevated i