Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Patricia M. Walden"'
Autor:
Selvakumar Edwardraja, Artem Melman, Paolo Bollella, Jason Whitfield, Patricia M. Walden, Claudia E. Vickers, Evgeny Katz, Zhong Guo, Kirill Alexandrov
Publikováno v:
ACS Sensors. 6:3596-3603
Enzymatic polypeptide proteolysis is a widespread and powerful biological control mechanism. Over the last few years, substantial progress has been made in creating artificial proteolytic systems where an input of choice modulates the protease activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a68a948f17284e1077360f8ae2d55cb
https://doi.org/10.1021/acssensors.1c00845
https://doi.org/10.1021/acssensors.1c00845
Autor:
Wayne A. Johnston, Kirill Alexandrov, Sergey Mureev, Dejan Gagoski, Robert G. Parton, Shayli Varasteh Moradi, Patricia M. Walden, Kerrie-Ann McMahon
Publikováno v:
Journal of Proteome Research. 19:1522-1532
The rapid spread of arthropod-borne Zika virus poses a serious public health threat that calls for effective ways of controlling and treating viral infection. This in turn necessitates better understanding of the mechanisms of virus assembly and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fae3b001e91cd9ddab9ceca13cd978
https://doi.org/10.1021/acs.jproteome.9b00771
https://doi.org/10.1021/acs.jproteome.9b00771
Autor:
Zhong Guo, Kirill Alexandrov, Evgeny Katz, Jacobus P.J. Ungerer, Patricia M. Walden, Cagla Ergun Ayva, Oleh Smutok, Wayne A. Johnston, Artem Melman, Brett McWhinney
Publikováno v:
Angewandte Chemie (International ed. in English). 61(6)
Protein biosensors play an increasingly important role as reporters for research and clinical applications. Here we present an approach for the construction of fully integrated but modular electrochemical biosensors based on the principal component o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662f465687c5ed8c06871daec5df38ab
https://pubmed.ncbi.nlm.nih.gov/34633119
https://pubmed.ncbi.nlm.nih.gov/34633119
Autor:
Wayne A. Johnston, Selvakumar Edwardraja, Zhenling Cui, Jason Whitfield, Fernanda Ely, Elvira Wijker, Ignacio Retamal Lantadilla, Jacobus P.J. Ungerer, Patricia M. Walden, Claudia E. Vickers, Zhong Guo, Kirill Alexandrov
Publikováno v:
Journal of the American Chemical Society. 141:8128-8135
Allosteric protein switches are key controllers of information and energy processing in living organisms and are desirable engineered control tools in synthetic systems. Here we present a generally applicable strategy for construction of allosteric s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc86e251602011df4650d83b7fd5de23
https://doi.org/10.1021/jacs.8b12298
https://doi.org/10.1021/jacs.8b12298
Autor:
Lakshmanane Premkumar, Begoña Heras, Andrew E. Whitten, Jennifer L. Martin, Gordon J. King, Patricia M. Walden, Maria A. Halili
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
The disulfide isomerase α-DsbA2 from Wolbachia pipientisis is unexpectedly homotrimeric and lacks the ‘shape-shifting’ conformational flexibility that defines another trimeric disulfide isomerase, ScsC from Proteus mirabilis.
Disulfide-bond
Disulfide-bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12a9f8f731c639b56e7dd749ca080e7
https://doi.org/10.1107/s2059798318018442
https://doi.org/10.1107/s2059798318018442
Autor:
Patricia M Walden, Maria A Halili, Julia K Archbold, Fredrik Lindahl, David P Fairlie, Kenji Inaba, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81440 (2013)
The α-proteobacterium Wolbachia pipientis infects more than 65% of insect species worldwide and manipulates the host reproductive machinery to enable its own survival. It can live in mutualistic relationships with hosts that cause human disease, inc
Externí odkaz:
https://doaj.org/article/8ab836e21a37448581a777dff3304497
Autor:
Ignacio Retamal Lantadilla, Claudia E. Vickers, Patricia M. Walden, Jason Whitfield, Zhong Guo, Kirill Alexandrov, Wayne A. Johnston, Selvakumar Edwardraja
Publikováno v:
ACS synthetic biology. 9(6)
The ability of proteins to interconvert unrelated biochemical inputs and outputs underlays most energy and information processing in biology. A common conversion mechanism involves a conformational change of a protein receptor in response to a ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e272d5250a32e8fd932364a02f753f27
https://pubmed.ncbi.nlm.nih.gov/32339455
https://pubmed.ncbi.nlm.nih.gov/32339455
Autor:
Jennifer L. Martin, David P. Fairlie, Wilko Duprez, Begoña Heras, Maria A. Halili, Lakshmanane Premkumar, Fabian Kurth, Patricia M. Walden
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
The gene product of M. tuberculosis Rv2969c is shown to be a disulfide oxidase enzyme that has a canonical DsbA-like fold with novel structural and functional characteristics.
The bacterial disulfide machinery is an attractive molecular target f
The bacterial disulfide machinery is an attractive molecular target f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78a084f8d35fbd3ea4f5a9c7c090604
https://doi.org/10.1107/s0907444913017800
https://doi.org/10.1107/s0907444913017800
Autor:
Jennifer L. Martin, Begoña Heras, Stephen R. Shouldice, Makrina Totsika, Patricia M. Walden, Mark A. Schembri
Publikováno v:
Antioxidants & Redox Signaling. 14:1729-1760
Since its discovery in 1991, the bacterial periplasmic oxidative folding catalyst DsbA has been the focus of intense research. Early studies addressed why it is so oxidizing and how it is maintained in its less stable oxidized state. The crystal stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378231f66b0e1e65af73765c5fc816bb
https://doi.org/10.1089/ars.2010.3344
https://doi.org/10.1089/ars.2010.3344
Autor:
Maria A. Halili, David P. Fairlie, Jennifer L. Martin, Kenji Inaba, Patricia M. Walden, Julia K. Archbold, Fredrik Lindahl
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81440 (2013)
PLoS ONE
PLoS ONE
The α-proteobacterium Wolbachia pipientis infects more than 65% of insect species worldwide and manipulates the host reproductive machinery to enable its own survival. It can live in mutualistic relationships with hosts that cause human disease, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d501297583ab6c1161bb1bda90bdf8ea
http://europepmc.org/articles/PMC3839904?pdf=render
http://europepmc.org/articles/PMC3839904?pdf=render