Výsledky vyhledávání - "Patricia M. Pooler"

Heterocellular gap junctional communication between alveolar epithelial cells

Autor: Michael Koval, Philip George, Patricia M Pooler, Valsamma Abraham, Rashmin C. Savani, Michael L. Chou, Aisha Zaman

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 280:L1085-L1093

We analyzed the pattern of gap junction protein (connexin) expression in vivo by indirect immunofluorescence. In normal rat lung sections, connexin (Cx)32 was expressed by type II cells, whereas Cx43 was more ubiquitously expressed and Cx46 was expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3994e4803b023c305243ece71a39bf
https://doi.org/10.1152/ajplung.2001.280.6.l1085

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Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line

Autor: Dennis B. Leeper, Charles S. Owen, Miriam L. Wahl, Per Briand, Patricia M. Pooler

Publikováno v: Journal of Cellular Physiology. 183:373-380

Tumor cells in vivo often exist in an ischemic microenvironment that would compromise the growth of normal cells. To minimize intracellular acidification under these conditions, these cells are thought to upregulate H+ transport mechanisms and/or slo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d054e87ccb64b476c58c108d6edadac
https://doi.org/10.1002/(sici)1097-4652(200006)183:3<373::aid-jcp10>3.0.co

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Temporal association between alterations in proton extrusion and low pH adaptation

Autor: Ronald A. Coss, Dennis B. Leeper, Miriam L. Wahl, Charles S. Owen, Patricia M. Pooler

Publikováno v: International Journal of Hyperthermia. 14:227-232

Cells which have been adapted to growth at low extracellular pH (pHe) typically develop both an upregulation of steady state intracellular pH (pHi) and an ability to develop thermotolerance to 42 degrees C hyperthermia. These properties were acquired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165400f13ad9fdb0f4f72f25558de4fa
https://doi.org/10.3109/02656739809018227

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Altered proton extrusion in cells adapted to growth at low extracellular pH

Autor: Patricia M. Pooler, Charles S. Owen, Ronald A. Coss, Dennis B. Leeper, Miriam L. Wahl

Publikováno v: Journal of Cellular Physiology. 173:397-405

Intracellular pH (pHi) homeostasis is crucial to cell survival. Cells that are chronically exposed to a low pH environment must adapt their hydrogen ion extrusion mechanisms to maintain their pHi in the physiologic range. An important component of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ba3f83c16d14891fb6c6a41b4c0befd
https://doi.org/10.1002/(sici)1097-4652(199712)173:3<397::aid-jcp12>3.0.co

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Hypotensive Mechanisms of Amifostine

Autor: Allan M. Lefer, Patricia M. Pooler, Sean V. Ryan, Carsten Skurk, Scott A. Waldman, Charles Nuss, S. L. Carrithers, Charles S. Owen, Scott J. Parkinson

Publikováno v: The Journal of Clinical Pharmacology. 36:365-373

Amifostine, a chemo- and radioprotective agent developed as adjunctive therapy for malignancies, induces hypotension after approximately 20% of patient administrations. This study examines the molecular mechanisms underlying hypotension induced by am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddabb34a0ca0007cd4ca4b64c10d762
https://doi.org/10.1002/j.1552-4604.1996.tb04214.x

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Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C

Autor: Patricia M. Pooler, Michael F. Beers, Zheng Cui, Marye H. Godinez, Erica Wentz, Philip L. Ballard, Rodolfo I. Godinez, Susan H. Guttentag, Rashmin C. Savani, Aisha Zaman, Linda W. Gonzales

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 281(3)

Intratracheal bleomycin in rats is associated with respiratory distress of uncertain etiology. We investigated the expression of surfactant components in this model of lung injury. Maximum respiratory distress, determined by respiratory rate, occurre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061e394783fbfa0934ceb85dee3a49ed
https://pubmed.ncbi.nlm.nih.gov/11504697

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Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis

Autor: Patricia M. Pooler, Zhao Zhou, Gaoyuan Cao, Aisha Zaman, Rashmin C. Savani, Horace M. DeLisser

Publikováno v: The Journal of biological chemistry. 276(39)

Hyaluronan (HA), an important glycosaminoglycan constituent of the extracellular matrix, has been implicated in angiogenesis. It appears to exert its biological effects through binding interactions with at least two cell surface receptors: CD44 and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9177b90de2e996801ecc995f1d63bccb
https://pubmed.ncbi.nlm.nih.gov/11448954

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