Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Patricia M. Kralik"'
Autor:
James B. Hoying, Yi Tan, Patricia M. Kralik, Laxminarayanan Krishnan, Hui Huang, Paul N. Epstein, Edward C. Carlson, Lu Cai, Shirong Zheng, Jianxiang Xu
Publikováno v:
International Journal of Biological Sciences
The effect of diabetes in vivo has not been examined on isolated podocytes. To achieve this, GFP was expressed constitutively in podocytes of PGFP transgenic mice which were bred to OVE mice to produce diabetic OVE-GFP mice. Viewing GFP fluorescence,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e07f5be2b683cbec47ca9f8edc86d6
https://doi.org/10.7150/ijbs.13057
https://doi.org/10.7150/ijbs.13057
Publikováno v:
Journal of Diabetes Research
Journal of Diabetes Research, Vol 2016 (2016)
Journal of Diabetes Research, Vol 2016 (2016)
The importance of proximal tubules dysfunction to diabetic albuminuria is uncertain. OVE26 mice have the most severe albuminuria of all diabetic mouse models but it is not known if impaired tubule uptake and processing are contributing factors. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03506e00cb4826229d42b6e0519b0e21
https://doi.org/10.1155/2016/8749417
https://doi.org/10.1155/2016/8749417
Autor:
Yunshi Long, Lu Yang, Patricia M. Kralik, Paul N. Epstein, Shirong Zheng, Jianxiang Xu, Sabine Waigel, Suzana Brozovic, Wolfgang Zacharias
Publikováno v:
Nephron Experimental Nephrology. 119:e8-e20
Aim: To define renal gene expression during the development of severe albuminuria in OVE26 diabetic mice. Methods: Kidney microarray analysis was performed at 2, 4 and 8 months. Data were validated by RT-PCR, in situ hybridization and immunohistochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dbbcf69eb39290fd43430392bdc8de
https://doi.org/10.1159/000324407
https://doi.org/10.1159/000324407
Autor:
Patricia M, Kralik, Gang, Ye, Naira S, Metreveli, Xia, Shem, Rajakumar V, Donthi, Paul N, Epstein
Publikováno v:
Cardiovascular Toxicology. 5:285-292
Cardiomyopathy is a major cause of mortality for both type 1 and 2 diabetic patients. However, experimental analysis of diabetic cardiomyopathy has focused on type 1 diabetes and there are few reports on cardiomyocyte dysfunction in the widely used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0750dd6e6688cc4452b5aa3cd4a599f
https://doi.org/10.1385/ct:5:3:285
https://doi.org/10.1385/ct:5:3:285
Autor:
Susan Coventry, Lu Yang, Haiyang Wei, Patricia M. Kralik, Paul N. Epstein, Yunshi Long, Ye Song, Shirong Zheng
Publikováno v:
The American journal of pathology. 175(2)
OVE26 diabetic mice develop severe albuminuria. Immunohistochemical analysis revealed a pattern of intense albumin staining in a small subset of OVE26 tubules. Immunostaining was strikingly heterogeneous; some tubules stained intensely for albumin, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65311fe96869cae2fc9dafe06eb44bce
https://pubmed.ncbi.nlm.nih.gov/19574429
https://pubmed.ncbi.nlm.nih.gov/19574429
Podocytes are critical components of the selective filtration barrier of the glomerulus and are susceptible to oxidative damage. For investigation of the role of oxidative stress and podocyte damage in diabetic nephropathy, transgenic mice that overe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acda23c246dc90a6029236b9fd41fef4
https://europepmc.org/articles/PMC2573005/
https://europepmc.org/articles/PMC2573005/
Publikováno v:
The review of diabetic studies : RDS. 3(3)
Type 1 and type 2 diabetic patients are at increased risk of cardiomyopathy and heart failure is a major cause of death for these patients. Cardiomyopathy in diabetes is associated with a cluster of features including decreased diastolic compliance,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b310e338b5868bcb793d96d92bf86d34
https://pubmed.ncbi.nlm.nih.gov/17487334
https://pubmed.ncbi.nlm.nih.gov/17487334
Autor:
Susan Coventry, Edward C. Carlson, Naira Metreveli, Shirong Zheng, Paul N. Epstein, William T. Noonan, Patricia M. Kralik
Publikováno v:
Diabetes. 53(12)
OVE26 mice are a transgenic model of severe early-onset type 1 diabetes. These mice develop diabetes within the first weeks of life and can survive well over a year with no insulin treatment, and they maintain near normal body weight. To determine wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660a1415e16982e10b72f7beb26cdd9d
https://pubmed.ncbi.nlm.nih.gov/15561957
https://pubmed.ncbi.nlm.nih.gov/15561957
Publikováno v:
Cardiovascular research. 53(2)
Objective : Cardiac glucose metabolism is critical to normal and pathological function. The significance of the first committed metabolic step, glucose phosphorylation, has not been established. In this study a new transgenic model was developed in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4595aa464ae87f41aa90e5a5ad92cd
https://pubmed.ncbi.nlm.nih.gov/11827693
https://pubmed.ncbi.nlm.nih.gov/11827693
Publikováno v:
Experientia. 32:723-725
Δ9 (10 mg/kg, i.p.) administered to mice immediately after withdrawal from a 3-day exposure to ethanol vapor was found to intensify withdrawal reactions. No effect was seen whenΔ9 was administered chronically during the exposure to ethanol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98d225546e100693173956a0b9917d37
https://doi.org/10.1007/bf01919854
https://doi.org/10.1007/bf01919854