Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Patricia M. Klockowski"'
Publikováno v:
The Journal of Clinical Pharmacology. 39:252-259
Venlafaxine is a clinically effective antidepressant. Caffeine is a metabolic probe for the quantitative measurement of CYP1A2 activity in vivo. This open-label study evaluated the effect of steady-state venlafaxine on CYP1A2-dependent metabolism, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb594354416d2ce4d9f21bcb3f49f3b3
https://doi.org/10.1177/009127009903900308
https://doi.org/10.1177/009127009903900308
Publikováno v:
The Journal of Clinical Pharmacology. 39:297-309
An open-label study evaluated the effect of steady-state venlafaxine on the single-dose pharmacokinetic profile of risperidone, a CYP2D6 substrate; its active metabolite, 9-hydroxyrisperidone; and the total active moiety (risperidone plus 9-hydroxyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b4bca8205a39fd58a59958e5249f61
https://doi.org/10.1177/009127009903900314
https://doi.org/10.1177/009127009903900314
Autor:
Paul H. Siedlik, David B. Haughey, Patricia M. Klockowski, Linda Balogh, Richard R. Brown, Mary S. Collis, Colleen A. McNaney
Publikováno v:
Journal of Pharmaceutical Sciences. 83:1582-1585
An analytical method was developed for the simultaneous reversed‐phase (cyano) high‐performance liquid chromatographic determination with fluorescence detection of tacrine and 1‐hydroxy‐, 2‐hydroxy‐, and 4‐hydroxytacrine in human plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1b8ce621f7ec556e5081dde98a0a31
https://doi.org/10.1002/jps.2600831113
https://doi.org/10.1002/jps.2600831113
Publikováno v:
Clinical Pharmacology and Therapeutics. 48:375-380
Calcium antagonists have been shown to depress hepatic enzymes and accelerate hepatic blood flow. This study was designed to compare the effects of two calcium antagonists, isradipine and diltiazem, on antipyrine and indocyanine green (ICG) clearance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edea3e5543613f7bdf7f38e1eb11244d
https://doi.org/10.1038/clpt.1990.165
https://doi.org/10.1038/clpt.1990.165
Autor:
Larry Ereshefsky, Jess Amchin, William Zarycranski, Dominick Albano, Karen P. Taylor, Patricia M. Klockowski
Publikováno v:
Journal of clinical pharmacology. 41(4)
Two antidepressants, venlafaxine and fluoxetine, were evaluated in vivo for their effect on cytochrome P450 2D6 (CYP2D6) activity, measured by the ratio of dextromethorphan, a sensitive CYP2D6 marker, to its metabolite dextrorphan (i.e., DM:DT) excre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0ad698bacf4d4b9e3340ddb8ea02c3
https://pubmed.ncbi.nlm.nih.gov/11304901
https://pubmed.ncbi.nlm.nih.gov/11304901
Publikováno v:
Journal of Pharmaceutical Sciences. 82:229-230
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e852b297b7f3c7a0bd448836de57a7
https://doi.org/10.1002/jps.2600820224
https://doi.org/10.1002/jps.2600820224
Autor:
Patricia M. Klockowski, Gerhard Levy
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 422:334-339
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f8353ad34634c2fd46ff5bd07f60ad
https://doi.org/10.1016/0378-4347(87)80472-3
https://doi.org/10.1016/0378-4347(87)80472-3
Publikováno v:
Pharmaceutical Research. :404-407
This investigation was designed to determine the effect of experimental hyperthyroidism on the hypnotic activity of a benzodiazepine and on the binding characteristics of the benzodiazepine receptor complex. Rats were made hyperthyroid by subcutaneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c6fc0aeac0470046e2c46a7ef106e63
https://doi.org/10.1023/a:1015983415887
https://doi.org/10.1023/a:1015983415887
Autor:
Patricia M. Klockowski, Gerhard Levy
Publikováno v:
Journal of Pharmaceutical Sciences. 76:516-520
Computer simulations were performed to determine if the threshold dose of an infused drug (rather than the drug concentration in the biophase at onset of action) can be a suitable index for pharmacodynamic investigations as proposed by others. A two-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0df7119d9b6c6b50931e5ab59cedd8
https://doi.org/10.1002/jps.2600760705
https://doi.org/10.1002/jps.2600760705
Autor:
Patricia M. Klockowski, Gerhard Levy
Publikováno v:
Journal of pharmaceutical sciences. 77(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c9421c8b9866c5f9730e97ae2c9fbe
https://pubmed.ncbi.nlm.nih.gov/3379597
https://pubmed.ncbi.nlm.nih.gov/3379597