Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Patricia M. Berninsone"'
Autor:
Amanda R Burnham-Marusich, Casey J Snodgrass, Anna M Johnson, Conrad M Kiyoshi, Sarah E Buzby, Matt R Gruner, Patricia M Berninsone
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49020 (2012)
Glycobiology research with Caenorhabditis elegans (C. elegans) has benefitted from the numerous genetic and cell biology tools available in this system. However, the lack of a cell line and the relative inaccessibility of C. elegans somatic cells in
Externí odkaz:
https://doaj.org/article/a836d746f14942d7ac2b1cc9b2b22e15
Publikováno v:
Genome Biology and Evolution
The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes. The CMAH gene is thought to be present in most
Autor:
Juliana L. Sacoman, Amanda R. Burnham-Marusich, Patricia M. Berninsone, Ruben K. Dagda, Raul Y. Dagda
Publikováno v:
Journal of Biological Chemistry. 292:4499-4518
O-Linked N-acetylglucosamine transferase (OGT) catalyzes O-GlcNAcylation of target proteins and regulates numerous biological processes. OGT is encoded by a single gene that yields nucleocytosolic and mitochondrial isoforms. To date, the role of the
The different proteins of any proteome evolve at enormously different rates. One of the primary factors influencing rates of protein evolution is expression level, with highly expressed proteins tending to evolve at slow rates. This phenomenon, known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0267adb8fccf5c8b0e2d3227c1a469d
https://ora.ox.ac.uk/objects/uuid:f74eb230-7f3c-4a73-957a-df62d4cc3d24
https://ora.ox.ac.uk/objects/uuid:f74eb230-7f3c-4a73-957a-df62d4cc3d24
Size-matched alkyne-conjugated cyanine fluorophores to identify differences in protein glycosylation
Publikováno v:
ELECTROPHORESIS. 35:2621-2625
Currently, there are few methods to detect differences in protein post-translational modifications (PTMs) in a specific manner from complex mixtures. Thus, we developed an approach that combines the sensitivity and specificity of Click Chemistry with
Publikováno v:
Molecular Biology and Evolution. 34(3)
The rates of evolution of the proteins of any organism vary across orders of magnitude. A primary factor influencing rates of protein evolution is expression. A strong negative correlation between expression levels and evolutionary rates (the so-call
Publikováno v:
Mitochondrion. 12:423-427
Nucleocytosolic and secreted proteins are commonly glycosylated. However, reports of glycosylated mitochondrial proteins are rare. Using lectin chromatography on bovine heart, we detected low-abundance glycoforms of nuclear-encoded proteins with well
Autor:
Elizabeth F. Ryder, Christopher T. Burket, Patricia M. Berninsone, Lynn C. Hull, Christina E. Higgins
Publikováno v:
Developmental Biology. 299:193-205
The adhesion of growing neurites into appropriate bundles or fascicles is important for the development of correct synaptic connectivity in the nervous system. We describe fasciculation defects of animals with mutations in the C. elegans gene dig-1 a
Publikováno v:
Glycobiology. 25(4)
Phosphorylcholine (PC) modification of proteins by pathogens has been implicated in mediating host-pathogen interactions. Parasitic nematodes synthesize PC-modified biomolecules that can modulate the host's antibody and cytokine production to favor n
Autor:
Patricia M. Berninsone, Brian J. Libby, Maria J. Gravato-Nobre, Carlos B. Hirschberg, Christine Göbel, Jörg Höflich, Jonathan Hodgkin, Ralf Baumeister, Samuel M. Politz, Creg Darby
Publikováno v:
Journal of Biological Chemistry. 279:30440-30448
During the establishment of a bacterial infection, the surface molecules of the host organism are of particular importance, since they mediate the first contact with the pathogen. In Caenorhabditis elegans, mutations in the srf-3 locus confer resista