Deux voies dépendantes de l'HIRA assurent la médiation du dépôt et du recyclage de novo du H3.3 pendant la transcription

Autor: Dominique Ray-Gallet, Ekaterina Boyarchuk, Antoine Coulon, Júlia Torné, Guillermo A. Orsi, Patricia Le Baccon, Geneviève Almouzni, Mickaël Garnier

Publikováno v: Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2020, 27 (11), pp.1057-1068. ⟨10.1038/s41594-020-0492-7⟩
Nature Structural and Molecular Biology, 2020, 27 (11), pp.1057-1068. ⟨10.1038/s41594-020-0492-7⟩
Nature Structural & Molecular Biology

International audience; Nucleosomes represent a challenge in regard to transcription. Histone eviction enables RNA polymerase II (RNAPII) progression through DNA, but compromises chromatin integrity. Here, we used the SNAP-tag system to distinguish n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bc1a689498fa00d0fae43b54674b99
https://hal.sorbonne-universite.fr/hal-03014199

Live-Cell Chromosome Dynamics and Outcome of X Chromosome Pairing Events during ES Cell Differentiation

Autor: Andrew S. Belmont, Patricia Le Baccon, Niall Murphy, Emmanuel Barillot, Isabelle Bonnet, Tim Pollex, Edith Heard, Isabel Brito, Osamu Masui, Philippe Hupé

Publikováno v: Cell
Cell, Elsevier, 2011, 145 (3), pp.447-458. ⟨10.1016/j.cell.2011.03.032⟩
Cell, 2011, 145 (3), pp.447-458. ⟨10.1016/j.cell.2011.03.032⟩

International audience; Random X inactivation represents a paradigm for monoallelic gene regulation during early ES cell differentiation. In mice, the choice of X chromosome to inactivate in XX cells is ensured by monoallelic regulation of Xist RNA v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6abeaa8a140310106d6158df4c43dbe
https://doi.org/10.1016/j.cell.2011.03.032

The IgG Fc receptor, FcγRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma

Autor: Patricia Le Baccon, Pascal Mossuz, Rifat Hamoudi, Christian Bastard, Gustav Klobeck, Dominique Leroux, Jean Jacques Sotto, Ruth Rimokh, Mary Callanan, Martin J. S. Dyer, Samuel Duley

Publikováno v: Proceedings of the National Academy of Sciences. 97:309-314

Rearrangement of chromosomal bands 1q21–23 is one of the most frequent chromosomal aberrations observed in hematological malignancy. The genes affected by these rearrangements remain poorly characterized. Typically, 1q21–23 rearrangements arise d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afbf9b99715f5a003cde21487781046
https://doi.org/10.1073/pnas.97.1.309

Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice

Autor: Patricia Diabangouaya, Jennifer C. Chow, Ikuhiro Okamoto, Patricia Le Baccon, Catherine Patrat, Vivian Vialon, Edith Heard

In mammals, X-chromosome dosage compensation is achieved by inactivating one of the two X chromosomes in females. In mice, X inactivation is initially imprinted, with inactivation of the paternal X (Xp) chromosome occurring during preimplantation dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c76f738320e552b7c4111ef2b5f07e
https://europepmc.org/articles/PMC2653561/

A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced

Autor: Anton Wutz, Edith Heard, Patricia Le Baccon, Julie Chaumeil

During early mammalian female development, one of the two X chromosomes becomes inactivated. Although X-chromosome coating by Xist RNA is essential for the initiation of X inactivation, little is known about how this signal is transformed into transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8b9001f97adcd2af85caf80003099b
https://europepmc.org/articles/PMC1553206/