Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Patricia L. St. John"'
Autor:
Manuel Patarroyo, Larysa Stroganova, Dorin-Bogdan Borza, Dale R. Abrahamson, Brooke M. Steenhard, Margaret G. Petroff, Patricia L. St. John, Adrian Zelenchuk
Publikováno v:
Kidney International. 96:1320-1331
Mammalian immune systems are not mature until well after birth. However, transfer of maternal IgG to the fetus and newborn usually provides immunoprotection from infectious diseases. IgG transfer occurs before birth in humans across the placenta and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b569f5dca9f0dd1850e1e85796711d4
https://doi.org/10.1016/j.kint.2019.06.014
https://doi.org/10.1016/j.kint.2019.06.014
Autor:
Brooke M Steenhard, Roberto Vanacore, David Friedman, Adrian Zelenchuk, Larysa Stroganova, Kathryn Isom, Patricia L St John, Billy G Hudson, Dale R Abrahamson
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50745 (2012)
Alport disease in humans, which usually results in proteinuria and kidney failure, is caused by mutations to the COL4A3, COL4A4, or COL4A5 genes, and absence of collagen α3α4α5(IV) networks found in mature kidney glomerular basement membrane (GBM)
Externí odkaz:
https://doaj.org/article/b8293eae6fa94091831038ce333a096f
Transgenic expression of human LAMA5 suppresses murine Lama5 mRNA and laminin α5 protein deposition.
Autor:
Brooke M Steenhard, Adrian Zelenchuk, Larysa Stroganova, Kathryn Isom, Patricia L St John, Glen K Andrews, Kenneth R Peterson, Dale R Abrahamson
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23926 (2011)
Laminin α5 is required for kidney glomerular basement membrane (GBM) assembly, and mice with targeted deletions of the Lama5 gene fail to form glomeruli. As a tool to begin to understand factors regulating the expression of the LAMA5 gene, we genera
Externí odkaz:
https://doaj.org/article/ce36c9499a88422188821db72e303a18
Autor:
Jeffrey H. Miner, Hani Suleiman, Patricia L. St. John, Adam R. Mezo, Florina Olaru, Andrey S. Shaw, Linna Ge, Dale R. Abrahamson, Wentian Luo, Dorin-Bogdan Borza
Publikováno v:
Journal of the American Society of Nephrology. 25:918-925
The neonatal Fc receptor (FcRn) is a major regulator of IgG and albumin homeostasis systemically and in the kidneys. We investigated the role of FcRn in the development of immune complex-mediated glomerular disease in mice. C57Bl/6 mice immunized wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec3eb3f6820f37bb140d5a66ab32fae
https://doi.org/10.1681/asn.2013050498
https://doi.org/10.1681/asn.2013050498
Autor:
Larysa Stroganova, Adrian Zelenchuk, Patricia L. St. John, Dale R. Abrahamson, Brooke M. Steenhard
Publikováno v:
Journal of Histochemistry and Cytochemistry
Kidney glomerular basement membranes (GBMs) undergo laminin and type IV collagen isoform substitutions during glomerular development, which are believed to be required for maturation of the filtration barrier. Specifically, GBMs of earliest glomeruli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05cce711b2135b4f031788171e4a5a0
https://doi.org/10.1369/0022155413501677
https://doi.org/10.1369/0022155413501677
Autor:
Matthew J. Williams, Naohiro Terada, Dale R. Abrahamson, Takashi Hamazaki, Gary W. Ellison, Christopher D. Batich, Edward A. Ross, William L. Clapp, Patricia L. St. John
Publikováno v:
Organogenesis. 8:49-55
Introduction To address transplant organ shortage, a promising strategy is to decellularize kidneys in a manner that the scaffold retains signals for seeded pluripotent precursor cells to differentiate and recapitulate native structures: matrix-to-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc97cf2e499929394ce1be0be916b07
https://doi.org/10.4161/org.20209
https://doi.org/10.4161/org.20209
Autor:
Lawrence B. Holzman, Adrian Zelenchuk, Dale R. Abrahamson, Larysa Stroganova, Patricia L. St. John, Kathryn Isom, Paul B. Freeburg, Brooke M. Steenhard
Publikováno v:
The American Journal of Pathology. 177:84-96
Vascular endothelial growth factor, which is critical for blood vessel formation, is regulated by hypoxia inducible transcription factors (HIFs). A component of the E3 ubiquitin ligase complex, von Hippel-Lindau (VHL) facilitates oxygen-dependent pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e529c2564ae44c990c76247e6a5c4f
https://doi.org/10.2353/ajpath.2010.090767
https://doi.org/10.2353/ajpath.2010.090767
Autor:
Dale R. Abrahamson, Dorin-Bogdan Borza, Larysa Stroganova, Patricia L. St. John, Billy G. Hudson
Publikováno v:
Journal of the American Society of Nephrology. 20:1471-1479
Laminin and type IV collagen composition of the glomerular basement membrane changes during glomerular development and maturation. Although it is known that both glomerular endothelial cells and podocytes produce different laminin isoforms at the app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84918319d5edda308aac9451682249e8
https://doi.org/10.1681/asn.2008101086
https://doi.org/10.1681/asn.2008101086
Autor:
Robin L. Maser, Brenda S. Magenheimer, James P. Calvet, Dale R. Abrahamson, Darren P. Wallace, Patricia L. St. John, Kathryn Isom, Jared J. Grantham, Robert C. De Lisle
Publikováno v:
Journal of the American Society of Nephrology. 17:3424-3437
Metanephric organ culture has been used to determine whether embryonic kidney tubules can be stimulated by cAMP to form cysts. Under basal culture conditions, wild-type kidneys from embryonic day 13.5 to 15.5 mice grow in size and continue ureteric b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0ddfdeebdf57c9e51f554c5d004618
https://doi.org/10.1681/asn.2006030295
https://doi.org/10.1681/asn.2006030295
Autor:
Alan R. Godwin, Patricia Cazcarro, Dale R. Abrahamson, Judy H. Dunmore, Brooke M. Steenhard, Patricia L. St. John, Kathryn Isom
Publikováno v:
Journal of the American Society of Nephrology. 16:1623-1631
Many stages of nephrogenesis can be studied using cultured embryonic kidneys, but there is no efficient technique available to readily knockdown or overexpress transgenes for rapid evaluation of resulting phenotypes. Embryonic stem (ES) cells have un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba2a892a39d849c5d3df8a87955bfc5
https://doi.org/10.1681/asn.2004070584
https://doi.org/10.1681/asn.2004070584