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pro vyhledávání: '"Patricia L. Orchansky"'
Publikováno v:
Journal of Biological Chemistry. 272:22940-22947
Interleukin (IL)-13 is a pleiotropic immunoregulatory cytokine that shares many, although not all, of the biological activities of IL-4. The overlapping biological properties of IL-4 and IL-13 appear to be due to the existence of shared components of
Publikováno v:
Molecular Immunology. 33:531-540
Depending on their prior antigen recognition history, mature T cells respond with different functional outcomes to T cell receptor (TCR) stimulation. These functional outcomes include proliferation, anergy and cell death. The biochemical basis underl
Autor:
Patricia L. Orchansky
Publikováno v:
Journal of Infection. 30:41-46
Trypanosoma cruzi, the aetiological agent of Chagas' disease, is able to parasitise almost any type of cell in the mammalian host. Only the macrophage, however, is potentially microbicidal for the parasite. The effectiveness of macrophages in killing
Publikováno v:
The Journal of biological chemistry. 274(30)
Interleukin (IL)-13 and IL-4 are pleiotropic immunoregulatory cytokines that share many overlapping biological properties reflecting the fact that both can utilize a receptor complex composed of the IL-4 receptor-alpha (IL-4Ralpha) chain and the IL-1
Publikováno v:
Molecular immunology. 33(10)
A well-known consequence of TCR stimulation in proliferating T cells is cell death by apoptosis. We have previously shown that the extent of tyrosine phosphorylation of TCR zeta, CD3 gamma, and CD3 epsilon subunits in proliferating CD4-CD8+ T cells a
Publikováno v:
Molecular and cellular biochemistry. 110(2)
A number of cell-surface proteins are anchored in plasma membranes by a glycosylated phosphatidylinositol (PI) moiety that is covalently attached to the carboxyl-terminal amino acid of the mature protein. We have previously reported the construction