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pro vyhledávání: '"Patricia L. Lederman"'
Autor:
Yi-Pin Lin, Patricia L. Lederman, Thomas M. Hart, Yanlei Yu, Ashley L. Marcinkiewicz, Robert J. Linhardt, Fuming Zhang
Publikováno v:
ACS Infect Dis
Lyme disease (LD) is caused by the spirochete Borrelia burgdorferi sensu lato (Bbsl). After transmission to humans by ticks, Bbsl spreads to multiple organs, leading to arthritis, carditis, and neuroborreliosis. No effective prophylaxis against human
Autor:
Patricia L. Lederman, Thomas M. Hart, Ilva Lieknina, Wen-Hsiang Chen, Peter Kraiczy, Utpal Pal, Ashley L. Marcinkiewicz, Yi-Pin Lin, Kaspars Tars, Jennifer L. Yates, Nicholas J. Mantis, Maria Elena Bottazzi, Xiuli Yang
Publikováno v:
Infect Immun
The spirochete Borrelia burgdorferisensu lato is the causative agent of Lyme disease (LD). The spirochetes produce the CspZ protein that binds to a complement regulator, factor H (FH). Such binding downregulates activation of host complement to facil