Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Patricia L. Gladstone"'
Autor:
Robert J. Ternansky, Patricia L. Gladstone, Zhuoqi Zhang, Graham Parry, Fernando Donate, Renzhong Fu, Jose Juarez, Amy L. Allan, Jinbao Xiang, Andrew P. Mazar, Xu Bai
Publikováno v:
MedChemComm. 7:1946-1951
An efficient strategy for the discovery of kinase inhibitors by a combination of diversity-oriented synthesis and selective screening is described. Initially, a set of 10 compounds representing a 10-scaffold library of diversity-oriented pyrimidine-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5f7ca18a4f4a40c7af850c56c2e9e9
https://doi.org/10.1039/c6md00351f
https://doi.org/10.1039/c6md00351f
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Wayne C. Guida, Robert J. Ternansky, Fernando Donate, Jason A Nydick, Patricia L. Gladstone, Tara E. Jackson, Jose Juarez, Melissa L. P. Price
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:107-110
A novel class of thymidine phosphorylase (TP) inhibitors has been designed based on analogy to the enzyme substrate as well as known inhibitors. Flexible docking studies, using a homology model of human TP, of the designed N-(2,4-dioxo-1,2,3,4-tetrah
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885282207c60a3ecc053886a18f63401
https://doi.org/10.1016/s0960-894x(02)00828-4
https://doi.org/10.1016/s0960-894x(02)00828-4
Publikováno v:
Organic Letters. 2:481-484
[reaction: see text] The syntheses of bis-trimethylstannanes 8, 10, 12-14, 16, 18, 21, and 22 are described. Treatment of these substances with approximately 5 equiv of CuCl in DMF at rt for 30-60 min effects, in each case, oxidative coupling between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1542e48ec21276d6e862e473f174b60c
https://doi.org/10.1021/ol9903988
https://doi.org/10.1021/ol9903988
Publikováno v:
Tetrahedron. 54:10609-10626
Copper(I) chloride-mediated oxidative homocouplings of a variety of substrates containing an alkenyltrimethylstannane function are reported. Thus, treatment of each of the stannanes 1–15 with 2.5 equivalents of CuCl in N,N-dimethylformamide (DMF) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe523dd50446dbc8b44a05fb41dff51
https://doi.org/10.1016/s0040-4020(98)00592-4
https://doi.org/10.1016/s0040-4020(98)00592-4
Autor:
Patricia L. Gladstone, Thomas G. Back
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9597839c33c1d0afd3490ce65b467b2e
https://doi.org/10.1002/chin.199406129
https://doi.org/10.1002/chin.199406129
Publikováno v:
ChemInform. 29
Copper(I) chloride-mediated oxidative homocouplings of a variety of substrates containing an alkenyltrimethylstannane function are reported. Thus, treatment of each of the stannanes 1–15 with 2.5 equivalents of CuCl in N,N-dimethylformamide (DMF) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f77cd4b49aff6fdcaf74058a42a9b0b
https://doi.org/10.1002/chin.199850074
https://doi.org/10.1002/chin.199850074
Publikováno v:
ChemInform. 31
The syntheses of bis-trimethylstannanes 8, 10, 12−14, 16, 18, 21, and 22 are described. Treatment of these substances with ∼5 equiv of CuCl in DMF at rt for 30−60 min effects, in each case, oxidative coupling between the two sp2 carbon centers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b69c057ee19b675e4c0136fb6295857
https://doi.org/10.1002/chin.200021057
https://doi.org/10.1002/chin.200021057
Autor:
David H. Jones, Aleksander W. Roszak, Penelope W. Codding, Joseph H.-L. Chau, Patricia L. Gladstone, Jacek W. Morzycki, Thomas G. Back
Publikováno v:
The Journal of Organic Chemistry. 57:4110-4121
The novel 3α- and 3β-hydroxy-B-homo-5-azasteroid lactams were prepared from testoterone. When the hydroxyl group in these compounds is converted into a leaving group, rearrangement to the corresponding A-nor azasteroids occurs under a variety of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43535372c3066aba2e66e4ddf3aa8fb
https://doi.org/10.1021/jo00041a013
https://doi.org/10.1021/jo00041a013
Autor:
Bruce Ganem, Fernando Donate, Amy L. Allan, Steven Ealick, Stephanie A. Hopkins, David E. Shaw, Yingbo Li, Weiru Wang, Melissa L. P. Price, Robert J. Ternansky, Jose C. Juarez, Patricia L. Gladstone
Publikováno v:
Journal of medicinal chemistry. 49(26)
A series of novel, multisubstrate, bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase (TP) is described. Thymidine phosphorylase has been implicated in angiogenesis and plays a significant role in tumor progression and metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1946995a92b5034f263a64a8fdb1f0c
https://pubmed.ncbi.nlm.nih.gov/17181163
https://pubmed.ncbi.nlm.nih.gov/17181163