Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo

Autor: Shuping Dong, Yolanda Sanchez, Tindy Li, Claudia E. Murar, Anthony J. Wilson, Brent W. Mccleland, Hongwei Qi, Patricia L. Podolin, Marc Galop, Christopher J. Moody, Hongxing Yan, John Yonchuk, Roderick S. Davis, Alan P. Graves, Catherine Booth-Genthe, Joseph P. Foley, Jen-Pyng Kou, Jeffrey K. Kerns, Brian Bolognese, James F. Callahan, Mary Mentzer, Lawrence Wolfe, Jeffrey C. Boehm, Robin Carr

Publikováno v: Bioorganic & Medicinal Chemistry. 27:579-588

The antioxidant natural product sulforaphane (SFN) is an oil with poor aqueous and thermal stability. Recent work with SFN has sought to optimize methods of formulation for oral and topical administration. Herein we report the design of new analogs o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b415f7b6666ea7f677038e87013d3b1
https://doi.org/10.1016/j.bmc.2018.12.026

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Autor: Patricia L. Podolin, Justyna Wojno-Picon, Baoqiang Guo, Andrew S. I. Loudon, Ryan Vonslow, Ryan P. Trump, Daniel Grant, Andrew S. MacDonald, Yolanda Sanchez, Anthony William James Cooper, Marie Pariollaud, D. Heulyn Jones, Brian Bolognese, Nicholas C. O. Tomkinson, Thomas Hopwood, Stefano Bresciani, David W. Ray, William J. Zuercher, Nicola Begley, Timothy M. Willson, Sheila Brown, Toryn Poolman, James P. Tellam, Dion A. Daniels, Ben Saer, Julie E. Gibbs

Publikováno v: Pariollaud, M, Gibbs, J, Hopwood, T, Brown, S, Begley, N, Vonslow, R, Poolman, T, Guo, B, Saer, B, Jones, D H, Tellam, J P, Bresciani, S, Tomkinson, N C, Wojno-Picon, J, Cooper, A W, Daniels, D A, Trump, R P, Grant, D, Zuercher, W, Willson, T M, MacDonald, A S, Bolognese, B, Podolin, P L, Sanchez, Y, Loudon, A S & Ray, D W 2018, ' Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation ', The Journal of clinical investigation, vol. 128, no. 6, pp. 2281-2296 . https://doi.org/10.1172/JCI93910
The Journal of Clinical Investigation

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b850d90e252cb0cef62edd168f157db
https://strathprints.strath.ac.uk/64982/1/Pariollaud_etal_JCI2018_Circadian_clock_component_REV_ERBa_controls_homeostatic_regulation.pdf

Hyperpolarized gas diffusion MRI of biphasic lung inflation in short- and long-term emphysema models

Autor: Rahim R. Rizi, Joseph P. Foley, Yi Xin, Kiarash Emami, Liam Hughes, Maurizio Cereda, Stephen Kadlecek, Natalie Meeder, Hooman Hamedani, Ian Duncan, Harrilla Profka, Jennia Rajaei, Brian Bolognese, Patricia L. Podolin, Joseph Naji

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 313(2)

During lung inflation, airspace dimensions are affected nonlinearly by both alveolar expansion and recruitment, potentially confounding the identification of emphysematous lung by hyperpolarized helium-3 diffusion magnetic resonance imaging (HP MRI).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1580e56acfdd5ce0d715b9a67c5240
https://pubmed.ncbi.nlm.nih.gov/28473321

Klotho and smoking - An interplay influencing the skeletal muscle function deficits that occur in COPD

Autor: Michael I. Polkey, Y.M. Andersson, Sonya Jackson, Nicholas Hart, Nicholas S Hopkinson, Anna Donaldson, Amy Lewis, Piet L.B. Bruijnzeel, Brian Bolognese, Joseph P. Foley, Mehul S. Patel, Jy Lee, Patricia L. Podolin, GS Haji, Paul R. Kemp, William D.-C. Man, Samantha A. Natanek

Publikováno v: Patel, M S, Donaldson, A V, Lewis, A, Natanek, S A, Lee, J Y, Andersson, Y M, Haji, G, Jackson, S G, Bolognese, B J, Foley, J P, Podolin, P L, Bruijnzeel, P L B, Hart, N, Hopkinson, N S, D-C Man, W, Kemp, P R & Polkey, M I 2016, ' Klotho and smoking-An interplay influencing the skeletal muscle function deficits that occur in COPD ', Respiratory Medicine . https://doi.org/10.1016/j.rmed.2016.02.004

Background Klotho is an ‘anti-ageing' hormone and transmembrane protein; Klotho deficient mice develop a similar ageing phenotype to smokers including emphysema and muscle wasting. The objective of this study was to evaluate skeletal muscle and cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1de696e67dd0a7d8309a7fb78eab7e
https://kclpure.kcl.ac.uk/ws/files/46992266/1_s2.0_S0954611116300221_main.pdf

Inhibition of Invariant Chain Processing, Antigen-Induced Proliferative Responses, and the Development of Collagen-Induced Arthritis and Experimental Autoimmune Encephalomyelitis by a Small Molecule Cysteine Protease Inhibitor

Autor: Michael S. McQueney, Roy A. Johanson, Elizabeth A. Capper-Spudich, Josephine H. Fox, Patricia L. Podolin, John J. Peterson, Robert W. Marquis, Edit Kurali, T. Gregg Davis, Dennis S. Yamashita, Stephen M. LoCastro, Gerald J. Terfloth, Brian R. Smith, Donald C. Carpenter, Edward Long, Xiaoyang Dong, Brian Bolognese

Publikováno v: The Journal of Immunology. 180:7989-8003

Members of the papain family of cysteine proteases (cathepsins) mediate late stage processing of MHC class II-bound invariant chain (Ii), enabling dissociation of Ii, and binding of antigenic peptide to class II molecules. Recognition of cell surface

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88df259ac244132f833d3d9196e414fd
https://doi.org/10.4049/jimmunol.180.12.7989