Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Patricia L Opresko"'
Autor:
Matthew A Schaich, Samantha L Sanford, Griffin A Welfer, Samuel A Johnson, Thu H Khoang, Patricia L Opresko, Bret D Freudenthal
Publikováno v:
eLife, Vol 9 (2020)
Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for
Externí odkaz:
https://doaj.org/article/4e22fc7309344751ac64f8a5732134ad
Autor:
Wenting Xie, Binxuan Jiao, Qing Bai, Vladimir A Ilin, Ming Sun, Charles E Burton, Dmytro Kolodieznyi, Michael J Calderon, Donna B Stolz, Patricia L Opresko, Claudette M St Croix, Simon Watkins, Bennett Van Houten, Marcel P Bruchez, Edward A Burton
Publikováno v:
eLife, Vol 9 (2020)
Mitochondrial dysfunction is implicated in the pathogenesis of multiple neurological diseases, but elucidation of underlying mechanisms is limited experimentally by the inability to damage specific mitochondria in defined neuronal groups. We develope
Externí odkaz:
https://doaj.org/article/fea3401affe0436d9e5cf88265371b5c
Autor:
Angela M. Hinchie, Samantha L. Sanford, Kelly E. Loughridge, Rachel M. Sutton, Anishka H. Parikh, Agustin A. Gil Silva, Daniel I. Sullivan, Pattra Chun-On, Matthew R. Morrell, John F. McDyer, Patricia L. Opresko, Jonathan K. Alder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The telomere sequence, TTAGGG, is conserved across all vertebrates and plays an essential role in suppressing the DNA damage response by binding a set of proteins termed shelterin. Changes in the telomere sequence impair shelterin binding, i
Externí odkaz:
https://doaj.org/article/1d8229a837ff47dab3abeb379196b575
Autor:
Aoife O'Donovan, Matthew S Pantell, Eli Puterman, Firdaus S Dhabhar, Elizabeth H Blackburn, Kristine Yaffe, Richard M Cawthon, Patricia L Opresko, Wen-Chi Hsueh, Suzanne Satterfield, Anne B Newman, Hilsa N Ayonayon, Susan M Rubin, Tamara B Harris, Elissa S Epel, Health Aging and Body Composition Study
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19687 (2011)
Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells
Externí odkaz:
https://doaj.org/article/38107a059a4e4a15bc597547864e6284
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11152 (2010)
Telomeres protect the chromosome ends and consist of guanine-rich repeats coated by specialized proteins. Critically short telomeres are associated with disease, aging and cancer. Defects in telomere replication can lead to telomere loss, which can b
Externí odkaz:
https://doaj.org/article/cfd13c46eab543599413a32b5f2f0714
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4825 (2009)
RecQ DNA helicases are critical for preserving genome integrity. Of the five RecQ family members identified in humans, only the Werner syndrome protein (WRN) possesses exonuclease activity. Loss of WRN causes the progeroid disorder Werner syndrome wh
Externí odkaz:
https://doaj.org/article/2d485540115f4c90ac1b5bcd4632cced
Autor:
Sanjana A. Thosar, Ryan P. Barnes, Ariana Detwiler, Ragini Bhargava, Anne Wondisford, Roderick J. O’Sullivan, Patricia L. Opresko
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113656- (2024)
Summary: Cancer cells maintain telomeres by upregulating telomerase or alternative lengthening of telomeres (ALT) via homology-directed repair at telomeric DNA breaks. 8-Oxoguanine (8oxoG) is a highly prevalent endogenous DNA lesion in telomeric sequ
Externí odkaz:
https://doaj.org/article/f73851718be544c6b21a5ffb5d002d87
Autor:
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Externí odkaz:
https://doaj.org/article/677d2112db5041e7bd30b5fcd641a24a
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Telomerase enzymes add telomeric repeats to the end of linear chromosomes. Here the authors reveal mechanisms by which oxidized dNTPs and therapeutic dNTPs inhibit telomerase-mediated telomere elongation.
Externí odkaz:
https://doaj.org/article/22fa7349443040f6a588333c1ddf1b4e
Autor:
Ru-Yi Zhu, Chandrima Majumdar, Cindy Khuu, Mariarosaria De Rosa, Patricia L. Opresko, Sheila S. David, Eric T. Kool
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1735-1742 (2020)
Externí odkaz:
https://doaj.org/article/b83d1007b30843a0aba07520da049229