Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Patricia Klemmer"'
Autor:
Juliane Lauks, Patricia Klemmer, Fatima Farzana, Ramesh Karupothula, Robbert Zalm, Nancy E Cooke, Ka Wan Li, August B Smit, Ruud Toonen, Matthijs Verhage
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39420 (2012)
Neurobeachin (Nbea) is a multidomain scaffold protein abundant in the brain, where it is highly expressed during development. Nbea-null mice have severe defects in neuromuscular synaptic transmission resulting in lethal paralysis of the newborns. Rec
Externí odkaz:
https://doaj.org/article/0ad1219ee7ac4e6a8531c41d5498cbea
Autor:
Pim van Nierop, Ka Wan Li, Titia Gebuis, Ronald E. van Kesteren, Chopie Hassan, August B. Smit, Patricia Klemmer, Miguel A. Gonzalez-Lozano
Publikováno v:
Gonzalez-Lozano, M A, Gebuis, T, Hassan, C, van Kesteren, R E, Smit, A B, Li, K W, van Nierop, P & Klemmer, P 2016, ' Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development ', Scientific Reports, vol. 6, pp. 35456 . https://doi.org/10.1038/srep35456
Scientific Reports, 6. Nature Publishing Group
Scientific Reports
Scientific Reports, 6. Nature Publishing Group
Scientific Reports
Development of the brain involves the formation and maturation of numerous synapses. This process requires prominent changes of the synaptic proteome and potentially involves thousands of different proteins at every synapse. To date the proteome anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a696d968897f8b992c0d0e6e879a6a
https://hdl.handle.net/1871.1/9661592c-515f-498d-b3ca-43faf373814d
https://hdl.handle.net/1871.1/9661592c-515f-498d-b3ca-43faf373814d
Publikováno v:
PROTEOMICS; Vol 12
Journal of Proteomics, 12(15-16), 2428-2432. Elsevier
Li, K W, Chen, N, Klemmer, P, Koopmans, F T W, Karupothula, R & Smit, A B 2012, ' Identifying true protein complex constituents in interaction proteomics: the example of the DMXL2 protein complex ', Journal of Proteomics, vol. 12, no. 15-16, pp. 2428-2432 . https://doi.org/10.1002/pmic.201100675
Journal of Proteomics, 12(15-16), 2428-2432. Elsevier
Li, K W, Chen, N, Klemmer, P, Koopmans, F T W, Karupothula, R & Smit, A B 2012, ' Identifying true protein complex constituents in interaction proteomics: the example of the DMXL2 protein complex ', Journal of Proteomics, vol. 12, no. 15-16, pp. 2428-2432 . https://doi.org/10.1002/pmic.201100675
A typical high-sensitivity antibody affinity purification-mass spectrometry experiment easily identifies hundreds of protein interactors. However, most of these are non-valid resulting from multiple causes other than interaction with the bait protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7b1f0b57a610c3c35366d6e9aeccd7
https://doi.org/10.1002/pmic.201100675
https://doi.org/10.1002/pmic.201100675
Autor:
Maarten Loos, Rhiannon M. Meredith, Ka Wan Li, Heidi de Wit, Jianru Stahl-Zeng, Diana C. Rotaru, Huibert D. Mansvelder, Oleg I. Klychnikov, Carl D. Holmgren, Patricia Klemmer, August B. Smit, Roel C. van der Schors, Joke Wortel, Sabine Spijker
Publikováno v:
Journal of Biological Chemistry, 286(29), 25495-25504. American Society for Biochemistry and Molecular Biology Inc.
Klemmer, P, Meredith, R M, Holmgren, C D, Klychnikov, O I, Stahl-Zeng, J, Loos, M, van der Schors, R C, Wortel, J, de Wit, H, Spijker, S, Rotaru, D C, Mansvelder, H D, Smit, A B & Li, K W 2011, ' Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype ', Journal of Biological Chemistry, vol. 286, no. 29, pp. 25495-25504 . https://doi.org/10.1074/jbc.M110.210260
Klemmer, P, Meredith, R M, Holmgren, C D, Klychnikov, O I, Stahl-Zeng, J, Loos, M, van der Schors, R C, Wortel, J, de Wit, H, Spijker, S, Rotaru, D C, Mansvelder, H D, Smit, A B & Li, K W 2011, ' Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype ', Journal of Biological Chemistry, vol. 286, no. 29, pp. 25495-25504 . https://doi.org/10.1074/jbc.M110.210260
Fragile X syndrome (FXS), the most common form of hereditary mental retardation, is caused by a loss-of-function mutation of the Fmr1 gene, which encodes fragile X mental retardation protein (FMRP). FMRP affects dendritic protein synthesis, thereby c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4403e0b7d6d9daae8c796e4766e7db
https://hdl.handle.net/1871/39860
https://hdl.handle.net/1871/39860
Publikováno v:
The Cytoskeleton ISBN: 9781627032650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::060d6f3381efac8d9998bea72684fcad
https://doi.org/10.1007/978-1-62703-266-7_11
https://doi.org/10.1007/978-1-62703-266-7_11
Autor:
Patricia Klemmer
Publikováno v:
Klemmer, P 2011, SDS-PAGE Immunoblot Analysis . in K W Li (ed.), Neuroproteomics . Neuromethods, no. 57, Humana Press, New York/Heidelberg, pp. 169-180 .
Neuromethods ISBN: 9781617791109
Neuromethods ISBN: 9781617791109
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e422bce1b0b85c952e4ae4b80d2eec56
https://research.vu.nl/en/publications/9e988324-d7cb-4f5a-9c62-4efa806665a8
https://research.vu.nl/en/publications/9e988324-d7cb-4f5a-9c62-4efa806665a8
Publikováno v:
Analytical and Bioanalytical Chemistry, 397(8), 3195-3202. Analytical and Bioanalytical Chemistry
Li, K W, Klemmer, P & Smit, A B 2010, ' Interaction proteomics of synapse protein complexes ', Analytical and Bioanalytical Chemistry, vol. 397, no. 8, pp. 3195-3202 . https://doi.org/10.1007/s00216-010-3658-z
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry; Vol 397
Li, K W, Klemmer, P & Smit, A B 2010, ' Interaction proteomics of synapse protein complexes ', Analytical and Bioanalytical Chemistry, vol. 397, no. 8, pp. 3195-3202 . https://doi.org/10.1007/s00216-010-3658-z
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry; Vol 397
The brain integrates complex types of information, and executes a wide range of physiological and behavioral processes. Trillions of tiny organelles, the synapses, are central to neuronal communication and information processing in the brain. Synapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254bffc9354309d6e902235dae517ea8
https://research.vu.nl/en/publications/5df588e3-dace-45de-9f4b-a8d0365483bd
https://research.vu.nl/en/publications/5df588e3-dace-45de-9f4b-a8d0365483bd
Publikováno v:
Journal of Proteomics, 72, 82-90. Elsevier
Klemmer, P, Smit, A B & Li, K W 2009, ' Proteomics analysis of immuno-precipitated synaptic protein complexes ', Journal of Proteomics, vol. 72, pp. 82-90 . https://doi.org/10.1016/j.jprot.2008.10.005
Klemmer, P, Smit, A B & Li, K W 2009, ' Proteomics analysis of immuno-precipitated synaptic protein complexes ', Journal of Proteomics, vol. 72, pp. 82-90 . https://doi.org/10.1016/j.jprot.2008.10.005
Synapses are key neuronal elements of the brain. They are responsible for transmission, integration, and storage of information between nerve cells. A synapse is considered as the most complex cellular organelle consisting of ~ 1500 of proteins that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cef6807893e0dffe1b53662413e4012
https://research.vu.nl/en/publications/5b4eabde-bf28-438d-886f-e44f230ca2f5
https://research.vu.nl/en/publications/5b4eabde-bf28-438d-886f-e44f230ca2f5
Autor:
Peter Donner, Felipe Monteclaro, Norbert Otto, Arndt Schmitz, Mario Mann, Sabine Daemmig, Julia Massier, Patricia Klemmer
Publikováno v:
GBM Annual Fall meeting Berlin/Potsdam 2005. 2005
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::563bcf282cfa0a3dceed6f58feb0c0c5
https://doi.org/10.1240/sav_gbm_2005_h_001266
https://doi.org/10.1240/sav_gbm_2005_h_001266