Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Patricia K. Sonsalla"'
Autor:
Reynolds K Brobey, Dwight German, Patricia K Sonsalla, Prem Gurnani, Johanne Pastor, C-C Hsieh, John Papaconstantinou, Philip P Foster, Makoto Kuro-o, Kevin P Rosenblatt
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139914 (2015)
Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant defense mechanism has not been locally investigated in the brain. Here, we tested the hypothesis
Externí odkaz:
https://doaj.org/article/2d036155ea0c407e9de22a09770a55f3
Autor:
Kang-Woo Lee, Xin Zhao, Joo-Young Im, Hilary Grosso, Won Hee Jang, Teresa W Chan, Patricia K Sonsalla, Dwight C German, Hidenori Ichijo, Eunsung Junn, M Maral Mouradian
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29935 (2012)
Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase 3 family, is activated by oxidative stress. The death-signaling pathway mediated by ASK1 is inhibited by DJ-1, which is linked to recessively inherited Park
Externí odkaz:
https://doaj.org/article/c697a2da9d4d4b5593046facb2d5996a
Publikováno v:
Toxicology and Applied Pharmacology. 273:355-364
Persistent neuroinflammation and microglial activation play an integral role in the pathogenesis of many neurological disorders. We investigated the role of voltage-gated sodium channels (VGSC) and Na(+)/H(+) exchangers (NHE) in the activation of imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e46060bfa741bdd78de3a02ae949717
https://doi.org/10.1016/j.taap.2013.09.011
https://doi.org/10.1016/j.taap.2013.09.011
Publikováno v:
Current Molecular Pharmacology. 5:340-349
Parkinson’s disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3d73c7d801324314bf6de13b3ba3a9b
https://doi.org/10.2174/1874467211205030003
https://doi.org/10.2174/1874467211205030003
Autor:
Lai Yoong Wong, Jason R. Richardson, Suzan L. Harris, Patricia K. Sonsalla, Ida Khobahy, Wenhao Li, Dwight C. German, Bharathi S. Gadad
Publikováno v:
Experimental Neurology. 234:482-487
Parkinson's disease (PD) is characterized by a prominent degeneration of nigrostriatal dopamine (DA) neurons with an accompanying neuroinflammation. Despite clinical and preclinical studies of neuroprotective strategies for PD, there is no effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98074913345aab6778b9e6c37e62fd98
https://doi.org/10.1016/j.expneurol.2012.01.022
https://doi.org/10.1016/j.expneurol.2012.01.022
Autor:
Eunsung Junn, Steven P. Braithwaite, Hilary Grosso, Patricia K. Sonsalla, José R. Fernández, Michael Voronkov, M. Maral Mouradian, Joo Young Im, Walter Chen, Kang Woo Lee, Neelanjana Ray, Yang Chao, Xuyan Feng, Jeffry B. Stock, Eliezer Masliah
Publikováno v:
The Journal of Neuroscience. 31:6963-6971
α-Synuclein (α-Syn) is a key protein that accumulates as hyperphosphorylated aggregates in pathologic hallmark features of Parkinson's disease (PD) and other neurodegenerative disorders. Phosphorylation of this protein at serine 129 is believed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8917be913e875496eafde8d6bb489079
https://doi.org/10.1523/jneurosci.6513-10.2011
https://doi.org/10.1523/jneurosci.6513-10.2011
Publikováno v:
Experimental Neurology. 221:329-334
Zonisamide is an FDA-approved antiepileptic drug that blocks voltage-dependent Na(+) channels and T-type Ca(2+) channels and improves clinical outcome in Parkinson's disease (PD) patients when used as an adjunct to other PD therapies. Zonisamide also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8796274071faee418f771a2231c784a2
https://doi.org/10.1016/j.expneurol.2009.11.018
https://doi.org/10.1016/j.expneurol.2009.11.018
Publikováno v:
Journal of Neurochemistry. 74:2217-2220
[3H]Dihydrotetrabenazine ([3H]DTBZ), a specific ligand for the vesicular monoamine transporter (VMAT2), has been used to characterize the integrity of monoaminergic nerve terminals in experimental animals and humans. The purpose of the present studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bbf342d082c8843d294d803e12ead9
https://doi.org/10.1046/j.1471-4159.2000.0742217.x
https://doi.org/10.1046/j.1471-4159.2000.0742217.x
Autor:
Kelly A. Hogan, Lawrence Manzino, Patricia K. Sonsalla, Elizabeth Jayatilleke, Martin R. Gluck, Lily Y. Moy
Publikováno v:
Journal of Neurochemistry. 79:152-160
The neurotoxic actions of methamphetamine (METH) may be mediated in part by reactive oxygen species (ROS). Methamphetamine administration leads to increases in ROS formation and lipid peroxidation in rodent brain; however, the extent to which protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f2dc7e8cdc4860cb5d8b09d6cbf8884
https://doi.org/10.1046/j.1471-4159.2001.00549.x
https://doi.org/10.1046/j.1471-4159.2001.00549.x
Autor:
Patricia K. Sonsalla, Lai Yoong Wong, Jason R. Richardson, David P. Crockett, Marcelo de Avilez Rocha
Publikováno v:
Journal of Neurochemistry. 106:231-243
Na(+)/H(+) exchanger (NHE) proteins are involved in intracellular pH and volume regulation and may indirectly influence neurotransmission. The abundant NHE isoform 1 (NHE1) has also been linked to brain cell damage during metabolic stress. It is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1288ba3a947b379d71306c50679094be
https://doi.org/10.1111/j.1471-4159.2008.05355.x
https://doi.org/10.1111/j.1471-4159.2008.05355.x