Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Patricia K. Curran"'
Autor:
Patricia K. Curran, Joseph A. Mindell, Gerdi Christine Kemmer, Thomas Günther Pomorski, Andreas L. Christensen, Marijonas Tutkus, Sune M. Christensen, Garima Ghale, Salome Veshaguri, Mads P. Møller, Bo Højen Justesen, Dimitrios Stamou, Ida Louise Jørgensen, Christina Lohr
Publikováno v:
Biophysical Journal. 108(2)
Regulated and selective transport of biomolecules across biological membranes is mediated by transporter proteins. These are essential in physiological processes ranging from electrical signaling in the nervous system to secretion of hormones and mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6833cceb4cc405c657c6e3ccd52b215e
Publikováno v:
Biochemistry. 45:6773-6782
Channels and transporters of the ClC family serve a variety of physiological functions. Understanding of their gating and transport mechanisms remains incomplete, with disagreement over the extent of protein conformational change involved. Using site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dd09346c333b890291ef4e75b12d94
https://doi.org/10.1021/bi0523815
https://doi.org/10.1021/bi0523815
Publikováno v:
Biochemistry. 41:8019-8030
Prolonged agonist exposure often induces downregulation of G protein-coupled receptors (GPCRs). Although downregulation of the prototypical beta(2)-adrenergic receptor (beta(2)AR) has been extensively studied, the underlying mechanisms have yet to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def4e899e0a1b51560f3fae2e228c6a3
https://doi.org/10.1021/bi025538r
https://doi.org/10.1021/bi025538r
Autor:
John D. Alvaro, Patricia K. Curran, Peter H. Fishman, Ronald S. Duman, Ginger A. Hoffman, Curtis A. Machida, Philip A. Iredale, Laura Rydelek Fitzgerald, Zhongwei Li, Vidita A. Vaidya, Richard Hsu
Publikováno v:
Europe PubMed Central
In the current study, we investigated the mechanism by which protein kinase C (PKC) regulates the expression of beta1-adrenergic receptor (beta1AR) mRNA in rat C6 glioma cells. Exposure of the cells to 4beta-phorbol-12-myristate-13-acetate (PMA), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a5d681d0f68021937eeb2291e4542c
https://doi.org/10.1124/mol.54.1.14
https://doi.org/10.1124/mol.54.1.14
Publikováno v:
Nature. 453(7196)
Lysosomes are the stomachs of the cell-terminal organelles on the endocytic pathway where internalized macromolecules are degraded. Containing a wide range of hydrolytic enzymes, lysosomes depend on maintaining acidic luminal pH values for efficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1043234244dfb5c89ffd0d00b8bc9cc
https://pubmed.ncbi.nlm.nih.gov/18449189
https://pubmed.ncbi.nlm.nih.gov/18449189
Publikováno v:
Journal of cell science. 117(Pt 5)
The beta(2)-adrenergic receptor (beta(2)AR) undergoes agonist-mediated endocytosis via clathrin-coated pits by a process dependent on both arrestins and dynamin. Internalization of some G protein-coupled receptors, however, is independent of arrestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e826180daec03d43376cfa51e4dea5de
https://pubmed.ncbi.nlm.nih.gov/14734649
https://pubmed.ncbi.nlm.nih.gov/14734649
Autor:
Patricia K. Curran, Peter H. Fishman
Publikováno v:
Cellular signalling. 8(5)
Although there is considerable interest in the regulation of the different beta-adrenergic receptor (AR) subtypes, most previous studies have utilized stably transfected cells expressing recombinant receptors under the control of viral promoters. Hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ce8d178b480500d041cf0f31556091
https://pubmed.ncbi.nlm.nih.gov/8911684
https://pubmed.ncbi.nlm.nih.gov/8911684
Publikováno v:
Journal of neurochemistry. 63(4)
Exposure of human SK-N-MC neurotumor cells to 4 beta-phorbol 12-myristate 13-acetate (PMA) increased isoproterenol stimulation of cyclic AMP levels by severalfold. This potentiation was blocked by inhibitors of protein kinase C (PKC) and did not occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d3ffa1a6b8d62063215432cefef69b
https://pubmed.ncbi.nlm.nih.gov/7931287
https://pubmed.ncbi.nlm.nih.gov/7931287
Autor:
Patricia K. Curran, Peter H. Fishman
Publikováno v:
FEBS letters. 314(3)
The fungal metabolite brefeldin A (BFA) is known to disrupt the Golgi apparatus resulting in redistribution of Golgi proteins to the endoplasmic reticulum and inhibition of protein secretion. BFA was found to inhibit protein synthesis in rat glioma C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0664e84798cdf26b1244b7f13e771e
https://pubmed.ncbi.nlm.nih.gov/1468570
https://pubmed.ncbi.nlm.nih.gov/1468570