Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Patricia K. A. Mongini"'
Publikováno v:
ImmunoHorizons. 7:333-352
Links between repeated microbial infections and B cell chronic lymphocytic leukemia (B-CLL) have been proposed but not tested directly. This study examines how prolonged exposure to a human fungal pathogen impacts B-CLL development in Eµ-hTCL1–tra
Autor:
Kanti R. Rai, Jacqueline C. Barrientos, Steven L. Allen, Patricia K. A. Mongini, Nicholas Chiorazzi, Jonathan E. Kolitz, Wentian Li, Rashmi Gupta, Xiao J. Yan
Publikováno v:
The Journal of Immunology. 202:2924-2944
Clonal expansion of B cell chronic lymphocytic leukemia (B-CLL) occurs within lymphoid tissue pseudofollicles. IL-15, a stromal cell–associated cytokine found within spleens and lymph nodes of B-CLL patients, significantly boosts in vitro cycling o
Autor:
Patricia K. A. Mongini, Jonathan E. Kolitz, Nicholas Chiorazzi, Jacqueline C. Barrientos, Rashmi Gupta, Xiao J. Yan, Steven L. Allen, Kanti R. Rai
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(5)
Malignant cell growth within patients with B cell chronic lymphocytic leukemia (B-CLL) is largely restricted to lymphoid tissues, particularly lymph nodes. The recent in vitro finding that TLR-9 ligand (oligodeoxynucleotide [ODN]) and IL-15 exhibit s
Autor:
Erin Boyle, Charles C. Chu, Jennifer Nieto, Tatjana Stankovic, Jela Bandovic, Jonathan E. Kolitz, Rashmi Gupta, Jacqueline C. Barrientos, Kanti R. Rai, Patricia K. A. Mongini, Joanna Stein, Nicholas Chiorazzi, Hyunjoo Lee, Steven L. Allen
Publikováno v:
The Journal of Immunology. 195:901-923
Clinical progression of B cell chronic lymphocytic leukemia (B-CLL) reflects the clone’s Ag receptor (BCR) and involves stroma-dependent B-CLL growth within lymphoid tissue. Uniformly elevated expression of TLR-9, occasional MYD88 mutations, and BC
Autor:
Patricia K A Mongini, Rashmi Gupta, Steven L Allen, Jacqueline Barrientos, Jonathan E Kolitz, Kanti Rai, Nicholas Chiorazzi
Publikováno v:
The Journal of Immunology. 202:182.62-182.62
Clonal expansion of B cell chronic lymphocytic leukemia (B-CLL) is linked to mutagenesis and occurs within lymphoid tissues. CpG DNA (ODN-2006) and IL-15, a cytokine found within stromal cells of B-CLL-infiltrated tissues, manifest striking synergy i
Autor:
Jonathan E. Kolitz, Matthew D. Scharff, Patricia K. A. Mongini, Thomas MacCarthy, Lu Zhang, Kanti R. Rai, Rajendra N. Damle, Sergio Roa, Amanda R. Magli, Steven L. Allen, Piers E.M. Patten, Charles C. Chu, Emilia Albesiano, Xiao-Jie Yan, Dorothy Kim, Jacqueline C. Barrientos, Nicholas Chiorazzi
Publikováno v:
Blood. 120:4802-4811
Clonal evolution occurs during the course of chronic lymphocytic leukemia (CLL) and activation-induced deaminase (AID) could influence this process. However, this possibility has been questioned in CLL because the number of circulating AID mRNA+ cell
Autor:
Shabirul Haque, Steven A. McCormick, Patricia K. A. Mongini, Joshua Trott, Nicholas Chiorazzi, Hyunjoo Lee
Publikováno v:
The Journal of Immunology. 185:5300-5314
Within inflammatory environments, B cells encountering foreign or self-Ag can develop tertiary lymphoid tissue expressing activation-induced cytosine deaminase (AID). Recently, this DNA-modifying enzyme was detected in nonlymphoid cells within severa
Autor:
Patricia K. A. Mongini, Rashmi Gupta, Stefano Vergani, Steven L. Allen, Jacqueline Barrientos, Jonathan Kolitz, Kanti Rai, Nicholas Chiorazzi
Publikováno v:
The Journal of Immunology. 200:122.11-122.11
B-cell chronic lymphocytic leukemia (B-CLL) clones express BCR specific for microbes and/or apoptotic cells and elevated TLR-9. In patients, B-CLL clonal expansion occurs within lymphoid tissues. We recently reported that CpG DNA (ODN-2006) and IL-15
Autor:
Rasem J. Fattah, Hanna Han, Mukundan Attur, Steven B. Abramson, John K. Inman, Patricia K. A. Mongini
Publikováno v:
The Journal of Immunology. 176:6736-6751
Of relevance to both protective and pathogenic responses to Ag is the recent finding that soluble molecules of the innate immune system, i.e., IL-4, B cell-activation factor of the TNF family (BAFF), and C3, exhibit significant synergy in promoting t
Autor:
Susan L. Kalled, Steven A. McCormick, Patricia K. A. Mongini, John K. Inman, Hanna Han, Rasem J. Fattah
Publikováno v:
The Journal of Immunology. 175:6143-6154
Foci of autoantigen-specific B lymphocytes in nonlymphoid tissues have been associated with development of autoimmune disease. To better understand the genesis of such ectopic lymphoid tissue, this study investigated whether several B cell-tropic inn