Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Patricia J. Wittkopp"'
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Phenotypic evolution is often caused by variation in gene expression resulting from altered gene regulatory mechanisms. Genetic variation affecting chromatin remodeling has been identified as a potential source of variable gene expression; h
Externí odkaz:
https://doaj.org/article/1a4d973dfc9a40edb40711bbf9e6700d
Publikováno v:
Evolution Letters, Vol 3, Iss 5, Pp 448-461 (2019)
Abstract Heritable variation in gene expression is common within species. Much of this variation is due to genetic differences outside of the gene with altered expression and is trans‐acting. This trans‐regulatory variation is often polygenic, wi
Externí odkaz:
https://doaj.org/article/e5e0737f12df455888cb33edfd2b15b4
Publikováno v:
Frontiers in Ecology and Evolution, Vol 8 (2020)
Drosophila pigmentation has been a fruitful model system for understanding the genetic and developmental mechanisms underlying phenotypic evolution. For example, prior work has shown that divergence of the tan gene contributes to pigmentation differe
Externí odkaz:
https://doaj.org/article/8b4dd081150d4891919e9c4faaf6665e
Publikováno v:
Fly, Vol 11, Iss 1, Pp 53-64 (2017)
Genome editing via the CRISPR/Cas9 RNA-guided nuclease system has opened up exciting possibilities for genetic analysis. However, technical challenges associated with homology-directed repair have proven to be roadblocks for producing changes in the
Externí odkaz:
https://doaj.org/article/5d09bdb8ef674aa59021343ba1098187
Autor:
Jonathan H. Massey, Noriyoshi Akiyama, Tanja Bien, Klaus Dreisewerd, Patricia J. Wittkopp, Joanne Y. Yew, Aya Takahashi
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Pleiotropic genes are genes that affect more than one trait. For example, many genes required for pigmentation in the fruit fly Drosophila melanogaster also affect traits such as circadian rhythms, vision, and mating behavior. Here, we present eviden
Externí odkaz:
https://doaj.org/article/8c837f5c334a493a88c234a5520db92f
Autor:
Gizem Kalay, Richard Lusk, Mackenzie Dome, Korneel Hens, Bart Deplancke, Patricia J. Wittkopp
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3419-3430 (2016)
The regulation of gene expression controls development, and changes in this regulation often contribute to phenotypic evolution. Drosophila pigmentation is a model system for studying evolutionary changes in gene regulation, with differences in expre
Externí odkaz:
https://doaj.org/article/ec132e4a272c4f8f8adf121f4f58032a
Autor:
Alisha V. John, Lisa L. Sramkoski, Elizabeth A. Walker, Arielle M. Cooley, Patricia J. Wittkopp
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 9, Pp 2955-2962 (2016)
To identify genetic variants underlying changes in phenotypes within and between species, researchers often utilize transgenic animals to compare the function of alleles in different genetic backgrounds. In Drosophila, targeted integration mediated b
Externí odkaz:
https://doaj.org/article/9783c70e14264513b98850dad34dca6c
Autor:
Joseph D. Coolon, Kraig R. Stevenson, C. Joel McManus, Brenton R. Graveley, Patricia J. Wittkopp
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 69-75 (2012)
Genomic imprinting occurs when expression of an allele differs based on the sex of the parent that transmitted the allele. In D. melanogaster, imprinting can occur, but its impact on allelic expression genome-wide is unclear. Here, we search for impr
Externí odkaz:
https://doaj.org/article/bb28d0063e7143c0adb3702b3d85035a
Publikováno v:
PLoS Genetics, Vol 19, Iss 12, p e1011078 (2023)
Genetic networks are surprisingly robust to perturbations caused by new mutations. This robustness is conferred in part by compensation for loss of a gene's activity by genes with overlapping functions, such as paralogs. Compensation occurs passively
Externí odkaz:
https://doaj.org/article/767ab5e5274a4f56a38b2d597422cf22
Autor:
Elphège P. Nora, Stein Aerts, Patricia J. Wittkopp, Harmen J. Bussemaker, Martha Bulyk, Saurabh Sinha, Julia Zeitlinger, Justin Crocker, Juan Ignacio Fuxman Bass
Publikováno v:
Cell Systems. 14:247-251