Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Patricia J. Lee"'
Autor:
Martin O. Evans, Darren M. Smith, Adrian T. Kress, Robert J. Nadeau, Daniel J. Selig, Diana Caridha, Ratanachat Racharaks, Thomas Langowski, Michael S. Madejczyk, Chance Carbaugh, David Saunders, Mark Widder, Jason De Meese, Patricia J. Lee, Jesse P. DeLuca
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract Plerixafor is a CXCR4 antagonist approved in 2008 by the FDA for hematopoietic stem cell collection. Subsequently, plerixafor has shown promise as a potential pathogen‐agnostic immunomodulator in a variety of preclinical animal models. Add
Externí odkaz:
https://doaj.org/article/e1f253fa61f04f4a85dd315fe4e40e06
Autor:
Joseph Lykins, Matthew J. Moschitto, Ying Zhou, Ekaterina V. Filippova, Hoang V. Le, Tadakimi Tomita, Barbara A. Fox, David J. Bzik, Chunlei Su, Seesandra V. Rajagopala, Kristin Flores, Furio Spano, Stuart Woods, Craig W. Roberts, Cong Hua, Kamal El Bissati, Kelsey M. Wheeler, Sarah Dovgin, Stephen P. Muench, Martin McPhillie, Colin W.G. Fishwick, Wayne F. Anderson, Patricia J. Lee, Mark Hickman, Louis M. Weiss, Jitender P. Dubey, Hernan A. Lorenzi, Richard B. Silverman, Rima L. McLeod
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108477- (2024)
Summary: Toxoplasma gondii causes morbidity, mortality, and disseminates widely via cat sexual stages. Here, we find T. gondii ornithine aminotransferase (OAT) is conserved across phyla. We solve TgO/GABA-AT structures with bound inactivators at 1.55
Externí odkaz:
https://doaj.org/article/4214ce2e3d344bdb89d711a4b2786ce4
Autor:
Patricia J. Lee
Publikováno v:
Journal of the Canadian Health Libraries Association, Vol 34, Iss 3 (2013)
Background: The Clinical Library (CL) is a virtual library of books, journals, drug information, and patient information. It has no hard copy books or journals to lend. Objectives: On the 10-year anniversary of the CL, feedback from information skill
Externí odkaz:
https://doaj.org/article/ddd46fbeb395480faf0f8c41da345465
Autor:
Mara Kreishman-Deitrick, Richard J. Sciotti, Brian Vesely, Jason C. Sousa, Elizabeth R. Sharlow, Patricia J. Lee, Tesfaye Teshome, John S. Lazo, Mozna Khraiwesh, Erica Penn, Brandon S. Pybus, Chau Vuong, Susan E. Leed, Diana Caridha, Gustave Bonkoungou
Publikováno v:
ACS Infectious Diseases. 7:506-517
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis affecting human populations, yet CL remains largely ignored in drug discovery programs. CL causes disfiguring skin lesions and often relapses after "clinical cure" using existing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27d57831295a01ada44f84b2b146bb61
https://doi.org/10.1021/acsinfecdis.0c00886
https://doi.org/10.1021/acsinfecdis.0c00886
Autor:
Clare E. Gutteridge, Brett W. Sadowski, Stephen M. Hughes, J. Alan Friedlander, Alicia D. Gaidry, Michael C. Baxter, Matthew B. Smith, Leighton G. Rodrigo, Michael T. O'Neil, Lucia Gerena, Patricia J. Lee, Ramadas Sathunuru, Montip Gettayacamin
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)).
Objective: A series of novel, substituted tetracyclic benzothiazepines were designed and prepared in an effort to optimize potency of this chemical class against drug-resistant strains of the malaria parasite. Method: Tetracyclic benzothiazepines bea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71d16e3a7cd48ef76e4ddf801eca977
https://pubmed.ncbi.nlm.nih.gov/35993460
https://pubmed.ncbi.nlm.nih.gov/35993460
Autor:
Tanja Grkovic, Jeffrey R. Livezey, Malik J. Raynor, Barry R. O’Keefe, Thomas Oliver, Lucas Poon, Mozna Khraiwesh, Thomas J. Langowski, Patricia J. Lee, Jesse P. DeLuca, Susan M. Ensel
Publikováno v:
Journal of Medicinal Plants Research. 14:451-457
Infections caused by Acinetobacter baumannii and other pathogenic bacteria are a worldwide concern due to their increasingly prevalent multidrug resistance. World leaders and health organizations across the globe have voiced their concerns over antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b3f3f774013c652af70dfdb4e9b6b4f
https://doi.org/10.5897/jmpr2020.6938
https://doi.org/10.5897/jmpr2020.6938
Autor:
Tyler Eck, John Gordon, Wayne E. Childers, Brandon S. Pybus, Dennis J. Colussi, Tamara Kreiss, Alison Roth, Rammohan R. Yadav Bheemanaboina, David P. Rotella, Shams Ul Mahmood, Patricia J. Lee, Purnima Bhanot, Samantha O. Aylor, Mariana Laureano de Souza, Mariana Lozano Gonzalez, John J. Siekierka
Publikováno v:
ACS Med Chem Lett
[Image: see text] The discovery of new targets for the treatment of malaria, in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8fe3378b6bb8e06313fdebf1e4dbd7
https://europepmc.org/articles/PMC8667308/
https://europepmc.org/articles/PMC8667308/
Autor:
Purnima Bhanot, Mariana Lozano Gonzalez, Brandon S. Pybus, John Gordon, Wayne E. Childers, David P. Rotella, Rammohan R. Yadav Bheemanaboina, Alison Roth, Shams Ul Mahmood, Tamara Kreiss, Tyler Eck, Mariana Laureano de Souza, John J. Siekierka, Dennis J. Colussi, Patricia J. Lee, Samantha O. Aylor
The discovery of new targets for treatment of malaria and in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f95d28b1facf94164495dca7105a0f
https://doi.org/10.1101/2021.11.05.467463
https://doi.org/10.1101/2021.11.05.467463
Autor:
Kassoum Kayentao, Joseph R. Francica, Carolina Barillas-Mury, Aissata Ongoiba, Rachel Vistein, T. Pholcharee, Photini Sinnis, Shanping Li, Safiatou Doumbo, Hyeseon Cho, Boubacar Traore, Barbara J. Flynn, Peter D. Crompton, Ming Zhao, Alison Roth, Lawrence Wang, Robert A. Seder, Mary E. Peterson, Lisa R. Olano, Lais Pereira, David Oyen, Azza H. Idris, Marlon Dillon, Ian A. Wilson, Patricia J. Lee, Samantha O. Aylor, Alvaro Molina-Cruz, Jeff Skinner, Sachie Kanatani, Arne Schön, Didier Doumtabe, Joshua Tan
Publikováno v:
Science translational medicine
Immunoglobulin (Ig)A antibodies play a critical role in protection against mucosal pathogens. However, the role of serum IgA in immunity to non-mucosal pathogens, such as Plasmodium falciparum, is poorly characterized, despite being the second most a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8556a9825d193b988d58bba913deb13b
https://doi.org/10.1126/scitranslmed.abg2344
https://doi.org/10.1126/scitranslmed.abg2344
Autor:
Diana Caridha, Qigui Li, Jangwoo Lee, Dylan Nugent, Susan E. Leed, Kirk Butler, Erin Milner, Eve Hosford, Amanda Schenk, Franklyn Ngundam, Richard J. Sciotti, Brian Vesely, Norma Roncal, Mara Kreishman-Deitrick, Chad C. Black, Patricia J. Lee, Mark Hickman, Lisa Xie, Gregory A. Reichard
Publikováno v:
Malaria Journal
Malaria Journal, Vol 18, Iss 1, Pp 1-15 (2019)
Malaria Journal, Vol 18, Iss 1, Pp 1-15 (2019)
Background Rodent malaria models are extensively used to predict treatment outcomes in human infections. There is a constant need to improve and refine these models by innovating ways to apply new scientific findings and cutting edge technologies. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9e25a3330f6b5558ae1af94808bd5f
https://doi.org/10.1186/s12936-019-2661-x
https://doi.org/10.1186/s12936-019-2661-x