Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Patricia Imbach"'
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/1168651eade84aa68bb9c377c9befbde
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug d
Externí odkaz:
https://doaj.org/article/8f2eff537f564b01931321a688bb396a
Autor:
Carlos García-Echeverría, Patricia Imbach, Johannes Roesel, Peter Fuerst, Marc Lang, Vito Guagnano, Maria Noorani, Johann Zimmermann, Pascal Furet
Publikováno v:
CHIMIA, Vol 57, Iss 4 (2003)
Peptidomimetics have been commonly used as lead compounds to design inhibitors with high affinity and specificity for a particular enzyme. The discovery that a 2-aminobenzylstatine derivative originally designed to target an aspartyl protease was abl
Externí odkaz:
https://doaj.org/article/f645dba53bc4403b88c8646f06f6571a
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Fred Sigoillot, Scott Gleim, Marie-Therese Stachyra, Jason Thomas, Damien Begue, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Seth Carbonneau, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Bea Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Claudio R. Thoma
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras (PROTACs) or molecular glues has emerged as a key modality in exploring new biology as well as designing new drug candidates where catalytic inhibition is neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b962ac1012caadf747a15217539d973e
https://doi.org/10.1101/2023.04.09.536153
https://doi.org/10.1101/2023.04.09.536153
Autor:
Robin A. Fairhurst, Pascal Furet, Patricia Imbach-Weese, Frédéric Stauffer, Heinrich Rueeger, Clive McCarthy, Sebastien Ripoche, Susanne Oswald, Bertrand Arnaud, Aline Jary, Michel Maira, Christian Schnell, Daniel A. Guthy, Markus Wartmann, Michael Kiffe, Sandrine Desrayaud, Francesca Blasco, Toni Widmer, Frank Seiler, Sascha Gutmann, Mark Knapp, Giorgio Caravatti
Publikováno v:
Journal of Medicinal Chemistry. 65:8345-8379
Balanced pan-class I phosphoinositide 3-kinase inhibition as an approach to cancer treatment offers the prospect of treating a broad range of tumor types and/or a way to achieve greater efficacy with a single inhibitor. Taking buparlisib as the start
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a308bfc3e4d7e6ca0655f9bedbe9796
https://doi.org/10.1021/acs.jmedchem.2c00267
https://doi.org/10.1021/acs.jmedchem.2c00267
Autor:
Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
Publikováno v:
ChemMedChem. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72eaa7a7b52b189acf9bc634916ec5d3
https://doi.org/10.1002/cmdc.202200514
https://doi.org/10.1002/cmdc.202200514
Autor:
Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
Publikováno v:
ChemMedChem. 17(19)
Inhibition of the YAP-TEAD protein-protein interaction is an attractive therapeutic concept under intense investigation with the objective to treat cancers associated with a dysregulation of the Hippo pathway. However, owing to the very extended surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e849912e1b00046650c0d4b1f52f7eb
https://pubmed.ncbi.nlm.nih.gov/35950546
https://pubmed.ncbi.nlm.nih.gov/35950546
Autor:
Valentin Djonov, Ruslan Hlushchuk, Monika Wnuk, Uyen Huynh-Do, Philipp Holzer, Gérald Tuffin, Patricia Imbach-Weese, Mathilde Janot, Georg Martiny-Baron
Publikováno v:
Kidney international
Eph receptor tyrosine kinases and their ligands (ephrins) have a pivotal role in the homeostasis of many adult organs and are widely expressed in the kidney. Glomerular diseases beginning with mesangiolysis can recover, with podocytes having a critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3501095ef731d2df08fac60d959eb9
Autor:
Patricia Imbach, Philipp Holzer, Mireille Ferretti, Christian Schnell, Pascal Furet, Georg Martiny-Baron, Eric Billy, Joseph Brueggen, Schmiedeberg Niko, Jeanette Marjorie Wood
Publikováno v:
Angiogenesis
EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. In addition, several reports suggest that this receptor ligand pair is also involved in pathologic vessel formation in adults incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3168a67413620869ea94ccafd06674
http://europepmc.org/articles/PMC2941628
http://europepmc.org/articles/PMC2941628
Autor:
Daniel Guthy, Marc Gerspacher, Jasmin Wirth, Robin Alec Fairhurst, Joachim Blanz, Van Huy Luu, Patricia Imbach-Weese, Robert Mah, Christian Schnell, Esther Roehn-Carnemolla, Giorgio Caravatti, Christine Fritsch, Francesca Blasco, Sandrine Desrayaud, Pascal Furet, Dorothee Arz, Mark Knapp
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(17)
A cyclisation within a 4',5-bisthiazole (S)-proline-amide-urea series of selective PI3Kα inhibitors led to a novel 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole tricyclic sub-series. The synthesis and optimisation of this 4,5-dihydrobenzo[1,2-d:3,4-d]bis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60daa3af87a8ebbadaf702752b2d5341
https://pubmed.ncbi.nlm.nih.gov/26199119
https://pubmed.ncbi.nlm.nih.gov/26199119