Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Patricia I. Mighiu"'
Autor:
Maureen J. Charron, Madhu Chari, Nikita R Christian, Jessica T.Y. Yue, Beatrice M. Filippi, Clair S. Yang, Carol K.L. Lam, Tony K.T. Lam, Patricia I. Mighiu, Mona A. Abraham
Publikováno v:
Nature Medicine. 19:766-772
Glucagon activates hepatic protein kinase A (PKA) to increase glucose production, but the gluco-stimulatory effect is transient even in the presence of continuous intravenous glucagon infusion. Continuous intravenous infusion of insulin, however, inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7d9ea1d8cb7edf6a59a4baabb6a399
https://doi.org/10.1038/nm.3115
https://doi.org/10.1038/nm.3115
Publikováno v:
Circulation Research. 110:1345-1354
Rationale: Dysregulation of hepatic triglyceride (TG)-rich very low-density lipoproteins (VLDL-TG) in obesity and type 2 diabetes contributes to the dyslipidemia that leads to cardiovascular morbidity. The central nervous system (CNS), particularly t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdd54ee73928dc2f28ae5c2ef93e460
https://doi.org/10.1161/circresaha.112.268276
https://doi.org/10.1161/circresaha.112.268276
Publikováno v:
Diabetes. 61:1350-1352
The upregulation of plasma inflammatory biomarkers in individuals with metabolic syndrome implies that activation of the innate immune response contributes to the pathogenesis of type 2 diabetes (1). Today, a large array of studies has demonstrated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f7e6ab78c3d6e5943a91b6bd841c27
https://doi.org/10.2337/db12-0330
https://doi.org/10.2337/db12-0330
Publikováno v:
Diabetes
Last year marked the ninetieth anniversary of the discovery of insulin by Nobel Laureates Frederick Banting and John Macleod, as well as Charles Best and James Bertram Collip. The initial success of insulin’s ability to lower glucose levels in type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea1602dd7f60cf891061113b4bc7484
https://doi.org/10.2337/db12-0048
https://doi.org/10.2337/db12-0048
Autor:
Beatrice M. Filippi, Mona A. Abraham, Mary P. LaPierre, Tony K.T. Lam, Patricia I. Mighiu, Jessica T.Y. Yue, Peter E. Light
Publikováno v:
Nature communications. 6
The brain emerges as a regulator of hepatic triglyceride-rich very-low-density lipoproteins (VLDL-TG). The neurocircuitry involved as well as the ability of fatty acids to trigger a neuronal network to regulate VLDL-TG remain unknown. Here we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd5962ff718f877b80d708632baae68
https://pubmed.ncbi.nlm.nih.gov/25580573
https://pubmed.ncbi.nlm.nih.gov/25580573
Autor:
Katie Lee, Penny Y.T. Wang, Teresa Y.Y. Lai, Clair S. Yang, Madhu Chari, Tony K.T. Lam, Patricia I. Mighiu, Andrea Kokorovic, Carol K.L. Lam, Grace W.C. Cheung
Publikováno v:
Diabetes
OBJECTIVE Circulating glucose inhibits glucose production in normal rodents and humans, but this glucose effectiveness is disrupted in diabetes due partly to sustained hyperglycemia. We hypothesize that hyperglycemia in diabetes impairs hypothalamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bbd9b74c25b98787fda4add4b93859
https://pubmed.ncbi.nlm.nih.gov/21562080
https://pubmed.ncbi.nlm.nih.gov/21562080