Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Patricia Hugues"'
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Akademický článek
Modeling Blast Crisis Using Mutagenized Chronic Myeloid Leukemia-Derived Induced Pluripotent Stem Cells (iPSCs)
Autor: Jusuf Imeri, Christophe Desterke, Paul Marcoux, Gladys Telliam, Safa Sanekli, Sylvain Barreau, Yucel Erbilgin, Theodoros Latsis, Patricia Hugues, Nathalie Sorel, Emilie Cayssials, Jean-Claude Chomel, Annelise Bennaceur-Griscelli, Ali G. Turhan
Publikováno v: Cells, Vol 12, Iss 4, p 598 (2023)
Purpose: To model CML progression in vitro and generate a blast crisis (BC-CML) model in vitro in order to identify new targets. Methods: Three different CML-derived iPSC lines were mutagenized with the alkylating agent ENU on a daily basis for 60 da
Externí odkaz: https://doaj.org/article/68ca13524a4b4e71bf4f8c1f1278d1db
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2
Akademický článek
Aryl hydrocarbon receptor (AHR) is a novel druggable pathway controlling malignant progenitor proliferation in chronic myeloid leukemia (CML).
Autor: Melanie Gentil, Patricia Hugues, Christophe Desterke, Gladys Telliam, Ivan Sloma, Lucas E B Souza, Seda Baykal, Jerome Artus, Frank Griscelli, Agnes Guerci, Hyacinthe Johnson-Ansah, Adlen Foudi, Annelise Bennaceur-Griscelli, Ali G Turhan
Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0200923 (2018)
Aryl Hydrocarbon Receptor (AHR) is an ubiquitous basic helix-loop-helix transcription factor, which is ligand-activated and involved in numerous biological processes including cell division, cell quiescence and inflammation. It has been shown that AH
Externí odkaz: https://doaj.org/article/5e1db4a946dc43a1b5c2b2cc75546c4c
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3
miR-495-3p sensitizes BCR-ABL1-expressing leukemic cells to tyrosine kinase inhibitors by targeting multidrug resistance 1 gene in T315I mutated cells
Autor: Yutthana Rittavee, Jérôme Artus, Christophe Desterke, Isidora Simanic, Lucas Eduardo Botelho de Souza, Sandra Riccaldi, Sabrina Coignard, Yousef Ijjeh, Patricia Hugues, Annelise Bennaceur-Griscelli, Ali G. Turhan, Adlen Foudi
Publikováno v: Experimental Hematology. 118:40-52
Chronic myeloid leukemia (CML) is a clonal hematopoietic malignancy driven by the BCR-ABL1 fusion oncoprotein. The development of tyrosine kinase inhibitors (TKIs) has deeply increased long-term survival of CML patients. Nonetheless, one patient out
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0632f676d858c9e276bf0f05d8a377
https://doi.org/10.1016/j.exphem.2022.12.003
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4
Impact of the Overexpression of the Tyrosine Kinase Receptor RET in the Hematopoietic Potential of Induced Pluripotent Stem Cells (iPSCs)
Autor: Paul Marcoux, Jusuf Imeri, Christophe Desterke, Theodoros Latsis, Diana Chaker, Patricia Hugues, Annelise Bennaceur-Griscelli, Ali G Turhan
Introduction: Previous studies have suggested that the tyrosine kinase receptor RET plays a sig-nificant role in the hematopoietic potential in mice and could also be used to expand cord-blood derived hematopoietic stem cells (HSCs). The role of RET
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f97535766e219cdc4b0028273087ea4
https://doi.org/10.20944/preprints202305.1252.v1
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6
Frequent altered distribution of peripheral B-lymphocyte subsets in pediatric and adolescent patients with classical Hodgkin lymphoma
Autor: Leila Hamdi, Roman Krzysiek, Thierry Leblanc, Rita Creidy, Houria Hendel-Chavez, Patricia Hugues, S. Boudjemaa, Caroline Besson, Judith Landman-Parker, Aurore Coulomb, Yassine Taoufik
Publikováno v: Leukemia & Lymphoma. 62:300-307
Peripheral lymphopenia is a well-known negative prognostic marker in classical Hodgkin lymphoma (cHL). We characterized the peripheral B-cell compartment in a prospective cohort of 83 pediatric cHL patients. We observed significantly low total B-cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5093bc588afae1b5402f308b68cb2f2
https://doi.org/10.1080/10428194.2020.1834090
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9
Single-Cell Transcriptome in Chronic Myeloid Leukemia: Pseudotime Analysis Reveals Evidence of Embryonic and Transitional Stem Cell States
Autor: Jean-Claude Chomel, Christoph Desterke, Lucas de Souza, Hervé Acloque, Adlen Foudi, Annelise Bennaceur-Griscelli, Frank Griscelli, Sarah Pagliaro, Ali G. Turhan, Patricia Hugues
Publikováno v: Experimental Hematology
Experimental Hematology, Elsevier, 2020, 85, pp.47-56. ⟨10.1016/j.exphem.2020.04.005⟩
International audience; Recent experimental data suggest that the heterogeneity of chronic myeloid leukemia (CML) stem cells may be the result of the development of unique molecular events generating functional consequences in terms of the resistance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582b0c10a07040df4b9391c133c3449d
https://pubmed.ncbi.nlm.nih.gov/32360510
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