The analysis of GSTA1 promoter genetic and functional diversity of human populations

Autor: Vid Mlakar, Patricia Huezo-Diaz Curtis, Marc Armengol, Victor Ythier, Isabelle Dupanloup, Khalil Ben Hassine, Laurence Lesne, Rabih Murr, Simona Jurkovic Mlakar, Tiago Nava, Marc Ansari

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract GSTA1 encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTA1 has several functional

Externí odkaz: https://doaj.org/article/3009698d325a4a0cbc6a555f80e7f449

Genetic Susceptibility to Hepatic Sinusoidal Obstruction Syndrome in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation

Autor: Robbert G. M. Bredius, Marc Ansari, Chakradhara Rao S. Uppugunduri, Veronica Del Vecchio, Yves Théorêt, Victor Lewis, Tiago Nava, Reginald Olivier Ralph, Patricia Huezo-Diaz Curtis, Pascal St-Onge, Christina Peters, Bill S. Kangarloo, Daniel Sinnett, Laurence Lesne, Simona Jurkovic Mlakar, Yves Chalandon, Maja Krajinovic, Mohamed Aziz Rezgui, Jean Hugues Dalle, Imke H. Bartelink, Jaap Jan Boelens, Henrique Bittencourt, Kateryna Petrykey, Jacques Cortyl, Patrick Beaulieu

Publikováno v: Biology of Blood and Marrow Transplantation, 26(5), 920-927. ELSEVIER SCIENCE INC
Biology of Blood and Marrow Transplantation, 26(5), 920-927. Elsevier Inc.
Ansari, M, Petrykey, K, Rezgui, M A, Del Vecchio, V, Cortyl, J, Ralph, R O, Nava, T, Beaulieu, P, St-Onge, P, Jurkovic Mlakar, S, Huezo-Diaz Curtis, P, Uppugunduri, C R S, Lesne, L, Théoret, Y, Chalandon, Y, Bartelink, I H, Boelens, J J, Bredius, R G M, Dalle, J H, Lewis, V, Kangarloo, B S, Peters, C, Sinnett, D, Bittencourt, H, Krajinovic, M & Pediatric Disease Working Party of the European Society for Blood and Marrow Transplantation 2020, ' Genetic Susceptibility to Hepatic Sinusoidal Obstruction Syndrome in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation ', Biology of Blood and Marrow Transplantation, vol. 26, no. 5, pp. 920-927 . https://doi.org/10.1016/j.bbmt.2019.11.026
Biology of Blood and Marrow Transplantation, Vol. 26, No 5 (2020) pp. 920-927

Sinusoidal obstruction syndrome (SOS) is a well-recognized and potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). SOS arises from endothelial cell damage and hepatocellular injury mostly due to the transplant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b98cf1d233d245c50456c92dc4951e
https://doi.org/10.1016/j.bbmt.2019.11.026

Incorporation ofGSTA1genetic variations into a population pharmacokinetic model for IV busulfan in paediatric hematopoietic stem cell transplantation

Autor: Marc Ansari, Patricia Huezo-Diaz Curtis, Mohamed Aziz Rezgui, Tiago Nava, Nastya Kassir, Catherine Litalien, Michel Duval, Henrique Bittencourt, Liane Esteves Daudt, Maja Krajinovic, Yves Théorêt, Chakradhara Rao S. Uppugunduri

Publikováno v: British Journal of Clinical Pharmacology. 84:1494-1504

Aims The aim of this study is to develop a population pharmacokinetic (PopPK) model for intravenous busulfan in children that incorporates variants of GSTA1, gene coding for the main enzyme in busulfan metabolism. Methods Busulfan concentration-time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd28415c6164304231150f8644e3383b
https://doi.org/10.1111/bcp.13566

GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study

Autor: Tao Schechter, Christina Peters, Jean-Hugues Dalle, Saba Azarnoush, Yves Théorêt, Yves Chalandon, Petr Sedlacek, Imke H. Bartelink, Tiago Nava, Jaap Jan Boelens, Laurence Lesne, Victor Lewis, M A Rezgui, Patricia Huezo-Diaz Curtis, Marc Ansari, Henrique Bittencourt, Robbert G. M. Bredius, Martin A. Champagne, L. Lee Dupuis, Chakradhara Rao S. Uppugunduri, Maja Krajinovic, Vid Mlakar

Publikováno v: Oncotarget, 8(53), 90852. Impact Journals
Oncotarget, 8(53), 90852-90867
Oncotarget
Ansari, M, Curtis, P H D, Uppugunduri, C R S, Rezgui, M A, Nava, T, Mlakar, V, Lesne, L, Théoret, Y, Chalandon, Y, Dupuis, L L, Schechter, T, Bartelink, I H, Boelens, J J, Bredius, R, Dalle, J H, Azarnoush, S, Sedlacek, P, Lewis, V, Champagne, M, Peters, C, Bittencourt, H & Krajinovic, M 2017, ' GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation : A multicenter study ', Oncotarget, vol. 8, no. 53, pp. 90852-90867 . https://doi.org/10.18632/oncotarget.20310
Oncotarget, Vol. 8, No 53 (2017) pp. 90852-90867
Oncotarget, 8(53), 90852-90867. Impact Journals

// Marc Ansari 1,2 , Patricia Huezo-Diaz Curtis 1,2,* , Chakradhara Rao S. Uppugunduri 1,2,* , Mohammed Aziz Rezgui 3 , Tiago Nava 1,3,5,6 , Vid Mlakar 1,2 , Laurence Lesne 1,2 , Yves Theoret 3,4,5 , Yves Chalandon 7 , Lee L. Dupuis 8 , Tao Schechter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f447b509f391c41e8a7406e4f3bb113
https://hdl.handle.net/1887/94621

Pharmacogenomics in Pediatric Oncology: Review of Gene—Drug Associations for Clinical Use

Autor: Marc Ansari, Vid Mlakar, Patricia Huezo-Diaz Curtis, Maja Krajinovic, Chakradhara Rao S. Uppugunduri

Publikováno v: International Journal of Molecular Sciences, Vol 17, Iss 9, p 1502 (2016)
International Journal of Molecular Sciences, Vol. 17, No 9 (2016)
International Journal of Molecular Sciences

During the 3rd congress of the European Society of Pharmacogenomics and Personalised Therapy (ESPT) in Budapest in 2015, a preliminary meeting was held aimed at establishing a pediatric individualized treatment in oncology and hematology committees.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b643fb506901cfa66cfe9854bc04cf6
https://doi.org/10.3390/ijms17091502