Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Autor: Alison P. Klein, Brian M. Wolpin, Harvey A. Risch, Rachael Z. Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J. Childs, Jason W. Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A. Arslan, Ana Babic, William R. Bamlet, Laura Beane-Freeman, Sonja I. Berndt, Amanda Blackford, Michael Borges, Ayelet Borgida, Paige M. Bracci, Lauren Brais, Paul Brennan, Hermann Brenner, Bas Bueno-de-Mesquita, Julie Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G. Chaffee, Charles C. Chung, Sean Cleary, Michelle Cotterchio, Frederike Dijk, Eric J. Duell, Lenka Foretova, Charles Fuchs, Niccola Funel, Steven Gallinger, J. Michael M. Gaziano, Maria Gazouli, Graham G. Giles, Edward Giovannucci, Michael Goggins, Gary E. Goodman, Phyllis J. Goodman, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Peter Hegyi, Kathy J. Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A. Holly, Robert Hoover, Rayjean J. Hung, Eric J. Jacobs, Krzysztof Jamroziak, Vladimir Janout, Rudolf Kaaks, Kay-Tee Khaw, Eric A. Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H. Kulke, Juozas Kupcinskas, Robert J. Kurtz, Daniel Laheru, Stefano Landi, Rita T. Lawlor, I.-Min Lee, Loic LeMarchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Mannisto, Roger L. Milne, Beatrice Mohelníková-Duchoňová, Rachel E. Neale, John P. Neoptolemos, Ann L. Oberg, Sara H. Olson, Irene Orlow, Claudio Pasquali, Alpa V. Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Ghislaine Scelo, Howard D. Sesso, Gianluca Severi, Xiao-Ou Shu, Debra Silverman, Jill P. Smith, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Francesca Tavano, Mark D. Thornquist, Geoffrey S. Tobias, Stephen K. Van Den Eeden, Yogesh Vashist, Kala Visvanathan, Pavel Vodicka, Jean Wactawski-Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen Chanock, Ofure Obazee, Gloria M. Petersen, Laufey T. Amundadottir

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci lin

Externí odkaz: https://doaj.org/article/62f48b33d3e24b21a7c8f4e240a960a1

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Autor: Sonja I. Berndt, Nicola J. Camp, Christine F. Skibola, Joseph Vijai, Zhaoming Wang, Jian Gu, Alexandra Nieters, Rachel S. Kelly, Karin E. Smedby, Alain Monnereau, Wendy Cozen, Angela Cox, Sophia S. Wang, Qing Lan, Lauren R. Teras, Moara Machado, Meredith Yeager, Angela R. Brooks-Wilson, Patricia Hartge, Mark P. Purdue, Brenda M. Birmann, Claire M. Vajdic, Pierluigi Cocco, Yawei Zhang, Graham G. Giles, Anne Zeleniuch-Jacquotte, Charles Lawrence, Rebecca Montalvan, Laurie Burdett, Amy Hutchinson, Yuanqing Ye, Timothy G. Call, Tait D. Shanafelt, Anne J. Novak, Neil E. Kay, Mark Liebow, Julie M. Cunningham, Cristine Allmer, Henrik Hjalgrim, Hans-Olov Adami, Mads Melbye, Bengt Glimelius, Ellen T. Chang, Martha Glenn, Karen Curtin, Lisa A. Cannon-Albright, W Ryan Diver, Brian K. Link, George J. Weiner, Lucia Conde, Paige M. Bracci, Jacques Riby, Donna K. Arnett, Degui Zhi, Justin M. Leach, Elizabeth A. Holly, Rebecca D. Jackson, Lesley F. Tinker, Yolanda Benavente, Núria Sala, Delphine Casabonne, Nikolaus Becker, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, Kari G. Chaffee, Sara J. Achenbach, Celine M. Vachon, Lynn R. Goldin, Sara S. Strom, Jose F. Leis, J. Brice Weinberg, Neil E. Caporaso, Aaron D. Norman, Anneclaire J. De Roos, Lindsay M. Morton, Richard K. Severson, Elio Riboli, Paolo Vineis, Rudolph Kaaks, Giovanna Masala, Elisabete Weiderpass, María- Dolores Chirlaque, Roel C. H. Vermeulen, Ruth C. Travis, Melissa C. Southey, Roger L. Milne, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Jacqueline Clavel, Tongzhang Zheng, Theodore R. Holford, Danylo J. Villano, Ann Maria, John J. Spinelli, Randy D. Gascoyne, Joseph M. Connors, Kimberly A. Bertrand, Edward Giovannucci, Peter Kraft, Anne Kricker, Jenny Turner, Maria Grazia Ennas, Giovanni M. Ferri, Lucia Miligi, Liming Liang, Baoshan Ma, Jinyan Huang, Simon Crouch, Ju-Hyun Park, Nilanjan Chatterjee, Kari E. North, John A. Snowden, Josh Wright, Joseph F. Fraumeni, Kenneth Offit, Xifeng Wu, Silvia de Sanjose, James R. Cerhan, Stephen J. Chanock, Nathaniel Rothman, Susan L. Slager

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease.

Externí odkaz: https://doaj.org/article/291f7f66c64e40539e0a55a7e9fcad49

Vitamin D metabolic pathway genes and pancreatic cancer risk.

Autor: Hannah Arem, Kai Yu, Xiaoqin Xiong, Kristin Moy, Neal D Freedman, Susan T Mayne, Demetrius Albanes, Alan A Arslan, Melissa Austin, William R Bamlet, Laura Beane-Freeman, Paige Bracci, Federico Canzian, Michelle Cotterchio, Eric J Duell, Steve Gallinger, Graham G Giles, Michael Goggins, Phyllis J Goodman, Patricia Hartge, Manal Hassan, Kathy Helzlsouer, Brian Henderson, Elizabeth A Holly, Robert Hoover, Eric J Jacobs, Aruna Kamineni, Alison Klein, Eric Klein, Laurence N Kolonel, Donghui Li, Núria Malats, Satu Männistö, Marjorie L McCullough, Sara H Olson, Irene Orlow, Ulrike Peters, Gloria M Petersen, Miquel Porta, Gianluca Severi, Xiao-Ou Shu, Kala Visvanathan, Emily White, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Geoffrey S Tobias, Dennis Maeder, Michelle Brotzman, Harvey Risch, Joshua N Sampson, Rachael Z Stolzenberg-Solomon

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0117574 (2015)

Evidence on the association between vitamin D status and pancreatic cancer risk is inconsistent. This inconsistency may be partially attributable to variation in vitamin D regulating genes. We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, V

Externí odkaz: https://doaj.org/article/4780aef1d7f5435182461f1e11d75b6e

Association between class III obesity (BMI of 40-59 kg/m2) and mortality: a pooled analysis of 20 prospective studies.

Autor: Cari M Kitahara, Alan J Flint, Amy Berrington de Gonzalez, Leslie Bernstein, Michelle Brotzman, Robert J MacInnis, Steven C Moore, Kim Robien, Philip S Rosenberg, Pramil N Singh, Elisabete Weiderpass, Hans Olov Adami, Hoda Anton-Culver, Rachel Ballard-Barbash, Julie E Buring, D Michal Freedman, Gary E Fraser, Laura E Beane Freeman, Susan M Gapstur, John Michael Gaziano, Graham G Giles, Niclas Håkansson, Jane A Hoppin, Frank B Hu, Karen Koenig, Martha S Linet, Yikyung Park, Alpa V Patel, Mark P Purdue, Catherine Schairer, Howard D Sesso, Kala Visvanathan, Emily White, Alicja Wolk, Anne Zeleniuch-Jacquotte, Patricia Hartge

Publikováno v: PLoS Medicine, Vol 11, Iss 7, p e1001673 (2014)

The prevalence of class III obesity (body mass index [BMI]≥40 kg/m2) has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness and death. Using data from a large pool

Externí odkaz: https://doaj.org/article/52f04016b75f4dc4a7edc83977842c0f

A pooled analysis of body mass index and mortality among African Americans.

Autor: Sarah S Cohen, Yikyung Park, Lisa B Signorello, Alpa V Patel, Deborah A Boggs, Laurence N Kolonel, Cari M Kitahara, Synnove F Knutsen, Elizabeth Gillanders, Kristine R Monroe, Amy Berrington de Gonzalez, Traci N Bethea, Amanda Black, Gary Fraser, Susan Gapstur, Patricia Hartge, Charles E Matthews, Song-Yi Park, Mark P Purdue, Pramil Singh, Chinonye Harvey, William J Blot, Julie R Palmer

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111980 (2014)

Pooled analyses among whites and East Asians have demonstrated positive associations between all-cause mortality and body mass index (BMI), but studies of African Americans have yielded less consistent results. We examined the association between BMI

Externí odkaz: https://doaj.org/article/7750968981a74d06bcc156dddc929f44